Does surgical history matter? A register-based study of 94 000 individuals from the Swedish osteoarthritis register on clinical profiles and outcomes of first-line treatment for knee osteoarthritis
Jönsson, Thérése LU ; Gustafsson, Kristin ; Cronström, Anna LU
and Ageberg, Eva
LU
(2026)
In Musculoskeletal Science and Practice
81.
- Abstract
- Background There is limited knowledge on whether prior knee surgery impacts the clinical profile and treatment outcomes for individuals with knee osteoarthritis (OA). Objectives The study aimed to (i) compare individual and clinical characteristics, and (ii) evaluate whether outcomes of first-line treatment differ between individuals with prior knee surgery and those without. Methods This study used data from the Swedish Osteoarthritis Register to compare individuals with and without prior knee surgery. Independent t-tests and chi-square tests analyzed characteristics, while linear and logistic regressions assessed group differences at the 3-month follow-up. Results Of the 94 116 individuals included, 15 637 (17 %) had prior knee surgery.... (More)
- Background There is limited knowledge on whether prior knee surgery impacts the clinical profile and treatment outcomes for individuals with knee osteoarthritis (OA). Objectives The study aimed to (i) compare individual and clinical characteristics, and (ii) evaluate whether outcomes of first-line treatment differ between individuals with prior knee surgery and those without. Methods This study used data from the Swedish Osteoarthritis Register to compare individuals with and without prior knee surgery. Independent t-tests and chi-square tests analyzed characteristics, while linear and logistic regressions assessed group differences at the 3-month follow-up. Results Of the 94 116 individuals included, 15 637 (17 %) had prior knee surgery. At baseline, those with prior knee surgery were more likely to be male (48 % vs. 29 %), younger (mean age 63 vs. 67 years), and meet physical activity recommendations (69 % vs. 66 %). At the 3-month follow-up, individuals with prior knee surgery had higher odds of expressing willingness to undergo surgery (OR 1.50 [95 % CI, 1.40 to 1.60]), experiencing walking difficulties (OR 1.24 [95 % CI, 1.19 to 1.30]), and to reaching the recommended level of physical activity (OR 1.21 [95 % CI, 1.14 to 1.27]). Conclusion The findings suggest that individuals with knee OA and a history of prior knee surgery may represent a specific clinical phenotype, characterized by a younger age, male sex, and higher levels of physical activity when entering first-line treatment. Despite positive treatment responses in both groups, individuals with a history of surgery more often reported ongoing clinical features at the 3-month follow-up. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/054680cc-8974-4193-8248-b5284ad91a00
- author
- Jönsson, Thérése
LU
; Gustafsson, Kristin
; Cronström, Anna
LU
and Ageberg, Eva
LU
- organization
- publishing date
- 2026
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Osteoarthritis, Knee, Surgery, Clinical characteristics, Cross-sectional, First-line treatment
- in
- Musculoskeletal Science and Practice
- volume
- 81
- article number
- 103457
- ISSN
- 2468-7812
- DOI
- 10.1016/j.msksp.2025.103457
- language
- English
- LU publication?
- yes
- id
- 054680cc-8974-4193-8248-b5284ad91a00
- alternative location
- https://www.sciencedirect.com/science/article/pii/S246878122500205X
- date added to LUP
- 2025-11-26 21:23:48
- date last changed
- 2025-11-27 07:58:47
@article{054680cc-8974-4193-8248-b5284ad91a00,
abstract = {{Background There is limited knowledge on whether prior knee surgery impacts the clinical profile and treatment outcomes for individuals with knee osteoarthritis (OA). Objectives The study aimed to (i) compare individual and clinical characteristics, and (ii) evaluate whether outcomes of first-line treatment differ between individuals with prior knee surgery and those without. Methods This study used data from the Swedish Osteoarthritis Register to compare individuals with and without prior knee surgery. Independent t-tests and chi-square tests analyzed characteristics, while linear and logistic regressions assessed group differences at the 3-month follow-up. Results Of the 94 116 individuals included, 15 637 (17 %) had prior knee surgery. At baseline, those with prior knee surgery were more likely to be male (48 % vs. 29 %), younger (mean age 63 vs. 67 years), and meet physical activity recommendations (69 % vs. 66 %). At the 3-month follow-up, individuals with prior knee surgery had higher odds of expressing willingness to undergo surgery (OR 1.50 [95 % CI, 1.40 to 1.60]), experiencing walking difficulties (OR 1.24 [95 % CI, 1.19 to 1.30]), and to reaching the recommended level of physical activity (OR 1.21 [95 % CI, 1.14 to 1.27]). Conclusion The findings suggest that individuals with knee OA and a history of prior knee surgery may represent a specific clinical phenotype, characterized by a younger age, male sex, and higher levels of physical activity when entering first-line treatment. Despite positive treatment responses in both groups, individuals with a history of surgery more often reported ongoing clinical features at the 3-month follow-up.}},
author = {{Jönsson, Thérése and Gustafsson, Kristin and Cronström, Anna and Ageberg, Eva}},
issn = {{2468-7812}},
keywords = {{Osteoarthritis; Knee; Surgery; Clinical characteristics; Cross-sectional; First-line treatment}},
language = {{eng}},
series = {{Musculoskeletal Science and Practice}},
title = {{Does surgical history matter? A register-based study of 94 000 individuals from the Swedish osteoarthritis register on clinical profiles and outcomes of first-line treatment for knee osteoarthritis}},
url = {{http://dx.doi.org/10.1016/j.msksp.2025.103457}},
doi = {{10.1016/j.msksp.2025.103457}},
volume = {{81}},
year = {{2026}},
}