X-rays can trigger the FLASH effect : Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice
(2018) In Radiotherapy and Oncology 129(3). p.582-588- Abstract
This study is the first proof of concept that the FLASH effect can be triggered by X-rays. Our results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with synchrotron generated X-rays does not induce memory deficit; it reduces hippocampal cell-division impairment and induces less reactive astrogliosis.
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https://lup.lub.lu.se/record/0629637e-1602-4e73-92c9-5ac0a57673f6
- author
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- keywords
- Cognitive impairment, Radiation-induced brain injury, Synchrotron radiation, Ultra-high dose-rate X-ray radiation
- in
- Radiotherapy and Oncology
- volume
- 129
- issue
- 3
- pages
- 582 - 588
- publisher
- Elsevier
- external identifiers
-
- pmid:30177374
- scopus:85052736289
- ISSN
- 0167-8140
- DOI
- 10.1016/j.radonc.2018.08.016
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: © 2018
- id
- 0629637e-1602-4e73-92c9-5ac0a57673f6
- date added to LUP
- 2021-11-03 18:16:34
- date last changed
- 2024-10-07 07:51:02
@article{0629637e-1602-4e73-92c9-5ac0a57673f6, abstract = {{<p>This study is the first proof of concept that the FLASH effect can be triggered by X-rays. Our results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with synchrotron generated X-rays does not induce memory deficit; it reduces hippocampal cell-division impairment and induces less reactive astrogliosis.</p>}}, author = {{Montay-Gruel, Pierre and Bouchet, Audrey and Jaccard, Maud and Patin, David and Serduc, Raphael and Aim, Warren and Petersson, Kristoffer and Petit, Benoit and Bailat, Claude and Bourhis, Jean and Bräuer-Krisch, Elke and Vozenin, Marie Catherine}}, issn = {{0167-8140}}, keywords = {{Cognitive impairment; Radiation-induced brain injury; Synchrotron radiation; Ultra-high dose-rate X-ray radiation}}, language = {{eng}}, number = {{3}}, pages = {{582--588}}, publisher = {{Elsevier}}, series = {{Radiotherapy and Oncology}}, title = {{X-rays can trigger the FLASH effect : Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice}}, url = {{http://dx.doi.org/10.1016/j.radonc.2018.08.016}}, doi = {{10.1016/j.radonc.2018.08.016}}, volume = {{129}}, year = {{2018}}, }