Longitudinal changes in cardiovascular disease–related proteins in welders
Dauter, Ulrike Maria ; Gliga, Anda Roxana ; Albin, Maria LU and Broberg, Karin LU
(2024)
In International Archives of Occupational and Environmental Health
97(7).
p.803-812
- Abstract
Objective: Occupational exposure to welding fumes is linked to a higher risk of cardiovascular disease; however, the threshold exposure level is unknown. Here, we aimed to identify changes in proteins associated with cardiovascular disease in relation to exposure to welding fumes. Methods: Data were obtained from two timepoints six years apart for 338 non-smoking men (171 welders, 167 controls); of these, 174 (78 welders, 96 controls) had measurements available at both timepoints. Exposure was measured as personal respirable dust (adjusted for personal protective equipment), welding years, and cumulative exposure. Proximity extension assays were used to measure a panel of 92 proteins involved in cardiovascular processes in serum... (More)
Objective: Occupational exposure to welding fumes is linked to a higher risk of cardiovascular disease; however, the threshold exposure level is unknown. Here, we aimed to identify changes in proteins associated with cardiovascular disease in relation to exposure to welding fumes. Methods: Data were obtained from two timepoints six years apart for 338 non-smoking men (171 welders, 167 controls); of these, 174 (78 welders, 96 controls) had measurements available at both timepoints. Exposure was measured as personal respirable dust (adjusted for personal protective equipment), welding years, and cumulative exposure. Proximity extension assays were used to measure a panel of 92 proteins involved in cardiovascular processes in serum samples. Linear mixed models were used for longitudinal analysis. The biological functions and diseases related to the identified proteins were explored using the Ingenuity Pathway Analysis software. Results: At both timepoints, the median respirable dust exposure was 0.7 mg/m3 for the welders. Seven proteins were differentially abundant between the welders and controls and increased incrementally with respirable dust: FGF23, CEACAM8, CD40L, PGF, CXCL1, CD84, and HO1. CD84 was significant after adjusting for multiple comparisons. These proteins have been linked to disorders of blood pressure, damage related to clogged blood vessels, and chronic inflammatory disorders. Conclusion: Exposure to mild steel welding fumes below current occupational exposure limits for respirable particles and welding fumes in Europe and the US (1–5 mg/m3) was associated with changes in the abundance of proteins related to cardiovascular disease. Further research should evaluate the utility of these proteins as prospective biomarkers of occupational cardiovascular disease.
(Less)
- author
- Dauter, Ulrike Maria
; Gliga, Anda Roxana
; Albin, Maria
LU
and Broberg, Karin
LU
- organization
- publishing date
- 2024-09
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- CVD, Occupational exposure limit, Respirable dust, Welding
- in
- International Archives of Occupational and Environmental Health
- volume
- 97
- issue
- 7
- pages
- 10 pages
- publisher
- Springer
- external identifiers
-
- scopus:85197406233
- pmid:38958674
- ISSN
- 0340-0131
- DOI
- 10.1007/s00420-024-02086-8
- language
- English
- LU publication?
- yes
- id
- 07720c66-3380-4af0-9c6d-da00a3dda9d6
- date added to LUP
- 2024-12-02 11:27:53
- date last changed
- 2025-07-15 05:27:16
@article{07720c66-3380-4af0-9c6d-da00a3dda9d6,
abstract = {{<p>Objective: Occupational exposure to welding fumes is linked to a higher risk of cardiovascular disease; however, the threshold exposure level is unknown. Here, we aimed to identify changes in proteins associated with cardiovascular disease in relation to exposure to welding fumes. Methods: Data were obtained from two timepoints six years apart for 338 non-smoking men (171 welders, 167 controls); of these, 174 (78 welders, 96 controls) had measurements available at both timepoints. Exposure was measured as personal respirable dust (adjusted for personal protective equipment), welding years, and cumulative exposure. Proximity extension assays were used to measure a panel of 92 proteins involved in cardiovascular processes in serum samples. Linear mixed models were used for longitudinal analysis. The biological functions and diseases related to the identified proteins were explored using the Ingenuity Pathway Analysis software. Results: At both timepoints, the median respirable dust exposure was 0.7 mg/m<sup>3</sup> for the welders. Seven proteins were differentially abundant between the welders and controls and increased incrementally with respirable dust: FGF23, CEACAM8, CD40L, PGF, CXCL1, CD84, and HO1. CD84 was significant after adjusting for multiple comparisons. These proteins have been linked to disorders of blood pressure, damage related to clogged blood vessels, and chronic inflammatory disorders. Conclusion: Exposure to mild steel welding fumes below current occupational exposure limits for respirable particles and welding fumes in Europe and the US (1–5 mg/m<sup>3</sup>) was associated with changes in the abundance of proteins related to cardiovascular disease. Further research should evaluate the utility of these proteins as prospective biomarkers of occupational cardiovascular disease.</p>}},
author = {{Dauter, Ulrike Maria and Gliga, Anda Roxana and Albin, Maria and Broberg, Karin}},
issn = {{0340-0131}},
keywords = {{CVD; Occupational exposure limit; Respirable dust; Welding}},
language = {{eng}},
number = {{7}},
pages = {{803--812}},
publisher = {{Springer}},
series = {{International Archives of Occupational and Environmental Health}},
title = {{Longitudinal changes in cardiovascular disease–related proteins in welders}},
url = {{http://dx.doi.org/10.1007/s00420-024-02086-8}},
doi = {{10.1007/s00420-024-02086-8}},
volume = {{97}},
year = {{2024}},
}