Risk of metabolic disorders in childless men : A population-based cohort study
(2018) In BMJ Open 8(8).- Abstract
Objective To study whether male childlessness is associated with an increased risk of metabolic disorders such as metabolic syndrome (MetS) and diabetes. Design A population-based cohort study. Setting Not applicable. Participants 2572 men from the population-based Malmö Diet and Cancer Cardiovascular Cohort. Interventions None. Main outcome measures From cross-sectional analyses, main outcome measures were ORs and 95% CIs for MetS and diabetes among childless men. In prospective analyses, HRs and 95% CI for diabetes among childless men. Results At baseline, in men with a mean age of 57 years, the prevalence of MetS was 26% and 22% among childless men and fathers, respectively. Similarly, we observed a higher prevalence of diabetes of... (More)
Objective To study whether male childlessness is associated with an increased risk of metabolic disorders such as metabolic syndrome (MetS) and diabetes. Design A population-based cohort study. Setting Not applicable. Participants 2572 men from the population-based Malmö Diet and Cancer Cardiovascular Cohort. Interventions None. Main outcome measures From cross-sectional analyses, main outcome measures were ORs and 95% CIs for MetS and diabetes among childless men. In prospective analyses, HRs and 95% CI for diabetes among childless men. Results At baseline, in men with a mean age of 57 years, the prevalence of MetS was 26% and 22% among childless men and fathers, respectively. Similarly, we observed a higher prevalence of diabetes of 11% among childless men compared with 5% among fathers. In the cross-sectional adjusted analyses, childless men had a higher risk of MetS and diabetes, with ORs of 1.22 (95% CI 0.87 to 1.72) and 2.12 (95% CI 1.34 to 3.36) compared with fathers. In the prospective analysis, during a mean follow-up of 18.3 years, we did not see any increase in diabetes risk among childless men (HR 1.02 (0.76 to 1.37)). Conclusion This study provides evidence of an association between male childlessness and a higher risk of MetS and diabetes. However, as these associations were found in cross-sectional analyses, reverse causation cannot be excluded.
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- author
- Bungum, Ane Berger LU ; Glazer, Clara Helene ; Bonde, Jens Peter ; Nilsson, Peter M. LU ; Giwercman, Aleksander LU and Tøttenborg, Sandra Søgaard
- organization
- publishing date
- 2018-08-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- childlessness, diabetes, infertility, metabolic syndrome, register-based cohort study
- in
- BMJ Open
- volume
- 8
- issue
- 8
- article number
- 020293
- publisher
- BMJ Publishing Group
- external identifiers
-
- pmid:30121591
- scopus:85051981702
- ISSN
- 2044-6055
- DOI
- 10.1136/bmjopen-2017-020293
- language
- English
- LU publication?
- yes
- id
- 08d3421b-b3d4-47e5-86b0-9ca0c38f30d8
- date added to LUP
- 2018-10-17 14:19:48
- date last changed
- 2024-08-20 01:27:49
@article{08d3421b-b3d4-47e5-86b0-9ca0c38f30d8, abstract = {{<p>Objective To study whether male childlessness is associated with an increased risk of metabolic disorders such as metabolic syndrome (MetS) and diabetes. Design A population-based cohort study. Setting Not applicable. Participants 2572 men from the population-based Malmö Diet and Cancer Cardiovascular Cohort. Interventions None. Main outcome measures From cross-sectional analyses, main outcome measures were ORs and 95% CIs for MetS and diabetes among childless men. In prospective analyses, HRs and 95% CI for diabetes among childless men. Results At baseline, in men with a mean age of 57 years, the prevalence of MetS was 26% and 22% among childless men and fathers, respectively. Similarly, we observed a higher prevalence of diabetes of 11% among childless men compared with 5% among fathers. In the cross-sectional adjusted analyses, childless men had a higher risk of MetS and diabetes, with ORs of 1.22 (95% CI 0.87 to 1.72) and 2.12 (95% CI 1.34 to 3.36) compared with fathers. In the prospective analysis, during a mean follow-up of 18.3 years, we did not see any increase in diabetes risk among childless men (HR 1.02 (0.76 to 1.37)). Conclusion This study provides evidence of an association between male childlessness and a higher risk of MetS and diabetes. However, as these associations were found in cross-sectional analyses, reverse causation cannot be excluded.</p>}}, author = {{Bungum, Ane Berger and Glazer, Clara Helene and Bonde, Jens Peter and Nilsson, Peter M. and Giwercman, Aleksander and Tøttenborg, Sandra Søgaard}}, issn = {{2044-6055}}, keywords = {{childlessness; diabetes; infertility; metabolic syndrome; register-based cohort study}}, language = {{eng}}, month = {{08}}, number = {{8}}, publisher = {{BMJ Publishing Group}}, series = {{BMJ Open}}, title = {{Risk of metabolic disorders in childless men : A population-based cohort study}}, url = {{http://dx.doi.org/10.1136/bmjopen-2017-020293}}, doi = {{10.1136/bmjopen-2017-020293}}, volume = {{8}}, year = {{2018}}, }