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Predictive biomarkers in radioresistant rectal cancer : A systematic review

Slipsager, Anna ; Henrichsen, Sofie N. ; Falkmer, Ursula G. ; Dybkær, Karen ; Belting, Mattias LU and Poulsen, Laurids (2023) In Critical Reviews in Oncology/Hematology 186.
Abstract

Background and aims: The treatment of locally advanced rectal cancer often consists of neoadjuvant chemoradiotherapy followed by surgery. However, approximately 15% of patients show no response to this neoadjuvant chemoradiotherapy. This systematic review aimed to identify biomarkers of innate radioresistant rectal cancer. Method: Through a systematic literature search, 125 papers were included and analyzed using ROBINS-I, a Cochrane risk of bias tool for non-randomized studies of interventions. Both statistically significant and nonsignificant biomarkers were identified. Biomarkers mentioned more than once in the results or biomarkers with a low or moderate risk of bias were included as the final results. Results: Thirteen unique... (More)

Background and aims: The treatment of locally advanced rectal cancer often consists of neoadjuvant chemoradiotherapy followed by surgery. However, approximately 15% of patients show no response to this neoadjuvant chemoradiotherapy. This systematic review aimed to identify biomarkers of innate radioresistant rectal cancer. Method: Through a systematic literature search, 125 papers were included and analyzed using ROBINS-I, a Cochrane risk of bias tool for non-randomized studies of interventions. Both statistically significant and nonsignificant biomarkers were identified. Biomarkers mentioned more than once in the results or biomarkers with a low or moderate risk of bias were included as the final results. Results: Thirteen unique biomarkers, three genetic signatures, one specific pathway, and two combinations of two or four biomarkers were identified. In particular, the connection between HMGCS2, COASY, and PI3K-pathway seems promising. Future scientific research should focus on further validating these genetic resistance markers.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Molecular biomarker, Neoadjuvant therapy, Radiotherapy, Rectal Neoplasms, Resistance
in
Critical Reviews in Oncology/Hematology
volume
186
article number
103991
publisher
Elsevier
external identifiers
  • scopus:85152905259
  • pmid:37059272
ISSN
1040-8428
DOI
10.1016/j.critrevonc.2023.103991
language
English
LU publication?
yes
id
095250d0-73d2-4220-afe9-913669d23de4
date added to LUP
2023-06-20 14:42:21
date last changed
2025-11-03 02:15:35
@article{095250d0-73d2-4220-afe9-913669d23de4,
  abstract     = {{<p>Background and aims: The treatment of locally advanced rectal cancer often consists of neoadjuvant chemoradiotherapy followed by surgery. However, approximately 15% of patients show no response to this neoadjuvant chemoradiotherapy. This systematic review aimed to identify biomarkers of innate radioresistant rectal cancer. Method: Through a systematic literature search, 125 papers were included and analyzed using ROBINS-I, a Cochrane risk of bias tool for non-randomized studies of interventions. Both statistically significant and nonsignificant biomarkers were identified. Biomarkers mentioned more than once in the results or biomarkers with a low or moderate risk of bias were included as the final results. Results: Thirteen unique biomarkers, three genetic signatures, one specific pathway, and two combinations of two or four biomarkers were identified. In particular, the connection between HMGCS2, COASY, and PI3K-pathway seems promising. Future scientific research should focus on further validating these genetic resistance markers.</p>}},
  author       = {{Slipsager, Anna and Henrichsen, Sofie N. and Falkmer, Ursula G. and Dybkær, Karen and Belting, Mattias and Poulsen, Laurids}},
  issn         = {{1040-8428}},
  keywords     = {{Molecular biomarker; Neoadjuvant therapy; Radiotherapy; Rectal Neoplasms; Resistance}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Critical Reviews in Oncology/Hematology}},
  title        = {{Predictive biomarkers in radioresistant rectal cancer : A systematic review}},
  url          = {{http://dx.doi.org/10.1016/j.critrevonc.2023.103991}},
  doi          = {{10.1016/j.critrevonc.2023.103991}},
  volume       = {{186}},
  year         = {{2023}},
}