Pancreatic islet uptake of sucrose and urea in the absence and presence of glucose
Lernmark, A. LU
; Sehlin, J.
and Taljedal, I. B.
(1974)
In Hormone Research
5(3).
p.182-186
- Abstract
Microdissected pancreatic islets of ob/ob mice were used to study whether glucose induced insulin release is associated with changes of the apparent extracellular space. Glucose at a concentration of 20 mM had no measurable effect on the islet uptake of sucrose and urea. In the presence of these space markers glucose stimulated insulin release significantly. The results do not invalidate the hypothesis that stimulation of insulin release is associated with increased endocytosis in the β cells. They suggest, however, that endocytosis does not represent a significant source of error when measuring the islet uptake of compounds in relation to extracellular space markers.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/0b9931b4-20fe-4e07-be13-99356af23bf4
- author
- Lernmark, A.
LU
; Sehlin, J.
and Taljedal, I. B.
- publishing date
- 1974-01-01
- type
- Contribution to journal
- publication status
- published
- in
- Hormone Research
- volume
- 5
- issue
- 3
- pages
- 182 - 186
- publisher
- Karger
- external identifiers
-
- scopus:0015950637
- pmid:4599420
- ISSN
- 0301-0163
- DOI
- 10.1159/000178629
- language
- English
- LU publication?
- no
- id
- 0b9931b4-20fe-4e07-be13-99356af23bf4
- date added to LUP
- 2019-09-18 12:20:03
- date last changed
- 2024-03-13 08:04:20
@article{0b9931b4-20fe-4e07-be13-99356af23bf4,
abstract = {{<p>Microdissected pancreatic islets of ob/ob mice were used to study whether glucose induced insulin release is associated with changes of the apparent extracellular space. Glucose at a concentration of 20 mM had no measurable effect on the islet uptake of sucrose and urea. In the presence of these space markers glucose stimulated insulin release significantly. The results do not invalidate the hypothesis that stimulation of insulin release is associated with increased endocytosis in the β cells. They suggest, however, that endocytosis does not represent a significant source of error when measuring the islet uptake of compounds in relation to extracellular space markers.</p>}},
author = {{Lernmark, A. and Sehlin, J. and Taljedal, I. B.}},
issn = {{0301-0163}},
language = {{eng}},
month = {{01}},
number = {{3}},
pages = {{182--186}},
publisher = {{Karger}},
series = {{Hormone Research}},
title = {{Pancreatic islet uptake of sucrose and urea in the absence and presence of glucose}},
url = {{http://dx.doi.org/10.1159/000178629}},
doi = {{10.1159/000178629}},
volume = {{5}},
year = {{1974}},
}