Cell cycle sibling rivalry Cdc2 vs. Cdk2
(2005) In Cell Cycle 4(11). p.1491-1494- Abstract
It has been long believed that the cyclin-dependent kinase 2 (Cdk2) binds to cyclin E or cyclin A and exclusively promotes the G1/S phase transition and that Cdc2/cyclin B complexes play a major role in mitosis. We now provide evidence that Cdc2 binds to cyclin E (in addition to cyclin A and B) and is able to promote the G1/S transition. This new concept indicates that both Cdk2 and/or Cdc2 can drive cells through G1/S phase in parallel. In this review we discuss the classic cell cycle model and how results from knockout mice provide new evidence that refute this model. We focus on the roles of Cdc2 and p27 in regulating the mammalian cell cycle and propose a new model for cell cycle regulation that... (More)
It has been long believed that the cyclin-dependent kinase 2 (Cdk2) binds to cyclin E or cyclin A and exclusively promotes the G1/S phase transition and that Cdc2/cyclin B complexes play a major role in mitosis. We now provide evidence that Cdc2 binds to cyclin E (in addition to cyclin A and B) and is able to promote the G1/S transition. This new concept indicates that both Cdk2 and/or Cdc2 can drive cells through G1/S phase in parallel. In this review we discuss the classic cell cycle model and how results from knockout mice provide new evidence that refute this model. We focus on the roles of Cdc2 and p27 in regulating the mammalian cell cycle and propose a new model for cell cycle regulation that accommodates these novel findings.
(Less)
- author
- Kaldis, Philipp LU and Aleem, Eiman
- publishing date
- 2005-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cdc2, Cdk2, Cyclin E, Cyclin-dependent kinase, Knockout mice, p27
- in
- Cell Cycle
- volume
- 4
- issue
- 11
- pages
- 1491 - 1494
- publisher
- Landes Bioscience
- external identifiers
-
- scopus:27744458480
- pmid:16258277
- ISSN
- 1538-4101
- DOI
- 10.4161/cc.4.11.2124
- language
- English
- LU publication?
- no
- id
- 0dedcdf4-d090-411e-a1de-88b05b7cd3f3
- date added to LUP
- 2019-09-18 14:25:32
- date last changed
- 2024-01-01 20:41:03
@article{0dedcdf4-d090-411e-a1de-88b05b7cd3f3, abstract = {{<p>It has been long believed that the cyclin-dependent kinase 2 (Cdk2) binds to cyclin E or cyclin A and exclusively promotes the G<sub>1</sub>/S phase transition and that Cdc2/cyclin B complexes play a major role in mitosis. We now provide evidence that Cdc2 binds to cyclin E (in addition to cyclin A and B) and is able to promote the G<sub>1</sub>/S transition. This new concept indicates that both Cdk2 and/or Cdc2 can drive cells through G<sub>1</sub>/S phase in parallel. In this review we discuss the classic cell cycle model and how results from knockout mice provide new evidence that refute this model. We focus on the roles of Cdc2 and p27 in regulating the mammalian cell cycle and propose a new model for cell cycle regulation that accommodates these novel findings.</p>}}, author = {{Kaldis, Philipp and Aleem, Eiman}}, issn = {{1538-4101}}, keywords = {{Cdc2; Cdk2; Cyclin E; Cyclin-dependent kinase; Knockout mice; p27}}, language = {{eng}}, month = {{01}}, number = {{11}}, pages = {{1491--1494}}, publisher = {{Landes Bioscience}}, series = {{Cell Cycle}}, title = {{Cell cycle sibling rivalry Cdc2 vs. Cdk2}}, url = {{http://dx.doi.org/10.4161/cc.4.11.2124}}, doi = {{10.4161/cc.4.11.2124}}, volume = {{4}}, year = {{2005}}, }