Intra-tumour IgA1 is common in cancer and is correlated with poor prognosis in bladder cancer.
(2016) In Heliyon 2(8).- Abstract
A high frequency of IgA1-positive tumour cells was found in tissue micro-arrays of oesophagus, colon, testis, lung, breast, bladder and ovarian cancer. IgA1 was observed in the cytoplasm and the plasma membrane. A correlation was found between intra-tumour IgA1 and poor overall survival in a large cohort of bladder cancer patients (n = 99, p = 0.011, log-rank test). The number of IgA1-positive tumour cells was also found to be higher in female than male bladder cancer patients. The presence of IgA1 was confirmed in formalin-fixed paraffin-embedded ovarian carcinoma samples using LC-MS/MS analysis. Uptake of IgA1 was also observed in breast cancer and melanoma cell lines when cultivated in the presence of serum from healthy individuals,... (More)
A high frequency of IgA1-positive tumour cells was found in tissue micro-arrays of oesophagus, colon, testis, lung, breast, bladder and ovarian cancer. IgA1 was observed in the cytoplasm and the plasma membrane. A correlation was found between intra-tumour IgA1 and poor overall survival in a large cohort of bladder cancer patients (n = 99, p = 0.011, log-rank test). The number of IgA1-positive tumour cells was also found to be higher in female than male bladder cancer patients. The presence of IgA1 was confirmed in formalin-fixed paraffin-embedded ovarian carcinoma samples using LC-MS/MS analysis. Uptake of IgA1 was also observed in breast cancer and melanoma cell lines when cultivated in the presence of serum from healthy individuals, indicating a possible origin of the IgA1 antibodies in cancer cells.
(Less)
- author
- Welinder, Charlotte
LU
; Jirström, Karin
LU
; Lehn, Sophie LU ; Nodin, Björn LU ; Marko-Varga, György LU ; Blixt, Ola ; Danielsson, Lena LU and Jansson, Bo LU
- organization
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Medicine
- in
- Heliyon
- volume
- 2
- issue
- 8
- article number
- e00143
- publisher
- Elsevier
- external identifiers
-
- pmid:27579449
- scopus:84989232417
- ISSN
- 2405-8440
- DOI
- 10.1016/j.heliyon.2016.e00143
- language
- English
- LU publication?
- yes
- id
- 0f6f9126-bf15-4a91-8859-a335f75ec95a
- date added to LUP
- 2017-02-16 15:45:06
- date last changed
- 2024-07-07 12:03:04
@article{0f6f9126-bf15-4a91-8859-a335f75ec95a, abstract = {{<p>A high frequency of IgA1-positive tumour cells was found in tissue micro-arrays of oesophagus, colon, testis, lung, breast, bladder and ovarian cancer. IgA1 was observed in the cytoplasm and the plasma membrane. A correlation was found between intra-tumour IgA1 and poor overall survival in a large cohort of bladder cancer patients (n = 99, p = 0.011, log-rank test). The number of IgA1-positive tumour cells was also found to be higher in female than male bladder cancer patients. The presence of IgA1 was confirmed in formalin-fixed paraffin-embedded ovarian carcinoma samples using LC-MS/MS analysis. Uptake of IgA1 was also observed in breast cancer and melanoma cell lines when cultivated in the presence of serum from healthy individuals, indicating a possible origin of the IgA1 antibodies in cancer cells.</p>}}, author = {{Welinder, Charlotte and Jirström, Karin and Lehn, Sophie and Nodin, Björn and Marko-Varga, György and Blixt, Ola and Danielsson, Lena and Jansson, Bo}}, issn = {{2405-8440}}, keywords = {{Medicine}}, language = {{eng}}, number = {{8}}, publisher = {{Elsevier}}, series = {{Heliyon}}, title = {{Intra-tumour IgA1 is common in cancer and is correlated with poor prognosis in bladder cancer.}}, url = {{http://dx.doi.org/10.1016/j.heliyon.2016.e00143}}, doi = {{10.1016/j.heliyon.2016.e00143}}, volume = {{2}}, year = {{2016}}, }