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Preterm arteries in childhood : Dimensions, intima-media thickness, and elasticity of the aorta, coronaries, and carotids in 6-y-old children born extremely preterm

Mohlkert, Lilly Ann ; Hallberg, Jenny ; Broberg, Olof LU ; Hellström, Monica ; Pegelow Halvorsen, Cecilia ; Sjöberg, Gunnar ; Edstedt Bonamy, Anna Karin ; Liuba, Petru LU ; Fellman, Vineta LU orcid and Domellöf, Magnus , et al. (2017) In Pediatric Research 81(2). p.299-306
Abstract

Background:Preterm birth increases risk for adult cardiovascular disease. We hypothesized that arteries in 6-y-old children born preterm are narrower, with thicker intima-media and stiffer than in peers born at term.Methods:Children born extremely preterm (EXP, n = 176, birthweights: 348-1,161 g) and at term (CTRL, n = 174, birthweights: 2,430-4,315 g) were included. Using ultrasonography, we determined diameters of the coronaries (CA), common carotid arteries (CCA) and aorta, the carotid intima media thickness (cIMT), and the stiffness index of the CCA and aorta.Results:Arteries were 5-10% narrower in EXP than in CTRL (P < 0.005) but after adjustment for body surface area, diameter differences diminished or disappeared. EXP-children... (More)

Background:Preterm birth increases risk for adult cardiovascular disease. We hypothesized that arteries in 6-y-old children born preterm are narrower, with thicker intima-media and stiffer than in peers born at term.Methods:Children born extremely preterm (EXP, n = 176, birthweights: 348-1,161 g) and at term (CTRL, n = 174, birthweights: 2,430-4,315 g) were included. Using ultrasonography, we determined diameters of the coronaries (CA), common carotid arteries (CCA) and aorta, the carotid intima media thickness (cIMT), and the stiffness index of the CCA and aorta.Results:Arteries were 5-10% narrower in EXP than in CTRL (P < 0.005) but after adjustment for body surface area, diameter differences diminished or disappeared. EXP-children born small for gestational age exhibited similar arterial dimensions as those born appropriate for date. The cIMT was 0.38 (SD = 0.04) mm and did not differ between groups. Carotid but not aortic stiffness was lower in EXP than in CTRL.Conclusion:In 6-y-old children born extremely preterm, conduit arteries are of similar or smaller size than in controls born at term, and they have no signs of accelerated intima media thickening or arterial stiffening. While these findings are reassuring for these children and their families, the causal pathways from preterm birth to adult cardiovascular disease remain unknown.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pediatric Research
volume
81
issue
2
pages
8 pages
publisher
International Pediatric Foundation Inc.
external identifiers
  • wos:000395359000005
  • pmid:28195589
  • scopus:85012906140
ISSN
0031-3998
DOI
10.1038/pr.2016.212
language
English
LU publication?
yes
id
0f7dab52-6c29-46dc-b933-92d72a835664
date added to LUP
2017-02-28 08:17:21
date last changed
2025-02-03 11:26:36
@article{0f7dab52-6c29-46dc-b933-92d72a835664,
  abstract     = {{<p>Background:Preterm birth increases risk for adult cardiovascular disease. We hypothesized that arteries in 6-y-old children born preterm are narrower, with thicker intima-media and stiffer than in peers born at term.Methods:Children born extremely preterm (EXP, n = 176, birthweights: 348-1,161 g) and at term (CTRL, n = 174, birthweights: 2,430-4,315 g) were included. Using ultrasonography, we determined diameters of the coronaries (CA), common carotid arteries (CCA) and aorta, the carotid intima media thickness (cIMT), and the stiffness index of the CCA and aorta.Results:Arteries were 5-10% narrower in EXP than in CTRL (P &lt; 0.005) but after adjustment for body surface area, diameter differences diminished or disappeared. EXP-children born small for gestational age exhibited similar arterial dimensions as those born appropriate for date. The cIMT was 0.38 (SD = 0.04) mm and did not differ between groups. Carotid but not aortic stiffness was lower in EXP than in CTRL.Conclusion:In 6-y-old children born extremely preterm, conduit arteries are of similar or smaller size than in controls born at term, and they have no signs of accelerated intima media thickening or arterial stiffening. While these findings are reassuring for these children and their families, the causal pathways from preterm birth to adult cardiovascular disease remain unknown.</p>}},
  author       = {{Mohlkert, Lilly Ann and Hallberg, Jenny and Broberg, Olof and Hellström, Monica and Pegelow Halvorsen, Cecilia and Sjöberg, Gunnar and Edstedt Bonamy, Anna Karin and Liuba, Petru and Fellman, Vineta and Domellöf, Magnus and Norman, Mikael}},
  issn         = {{0031-3998}},
  language     = {{eng}},
  month        = {{02}},
  number       = {{2}},
  pages        = {{299--306}},
  publisher    = {{International Pediatric Foundation Inc.}},
  series       = {{Pediatric Research}},
  title        = {{Preterm arteries in childhood : Dimensions, intima-media thickness, and elasticity of the aorta, coronaries, and carotids in 6-y-old children born extremely preterm}},
  url          = {{http://dx.doi.org/10.1038/pr.2016.212}},
  doi          = {{10.1038/pr.2016.212}},
  volume       = {{81}},
  year         = {{2017}},
}