A microcalorimetric study of water vapor sorption on morphine sulphate
(1999) In Journal of Thermal Analysis and Calorimetry 57(1). p.133-137- Abstract
- Water vapor sorption on morphine sulphate was studied in a twin double sorption microcalorimeter at 25°C. The vapor sorption isotherm and the differential heats of sorption were determined simultaneously from dry condition to a water activity of 0.99. Two well resolved hydration steps were obtained on the sorption isotherm at water activities of 0.01 and 0.22 corresponding to the formation of dihydrate and pentahydrate of morphine sulphate. They were accompanied by constant values of the differential heats of sorption: –24 kJ mol–1(H2O) for the dihydrate formation and –10 kJ mol–1(H2O) for the pentahydrate formation.
The calorimetrically obtained sorption isotherms were compared with the results of Karl Fisher titrations of... (More) - Water vapor sorption on morphine sulphate was studied in a twin double sorption microcalorimeter at 25°C. The vapor sorption isotherm and the differential heats of sorption were determined simultaneously from dry condition to a water activity of 0.99. Two well resolved hydration steps were obtained on the sorption isotherm at water activities of 0.01 and 0.22 corresponding to the formation of dihydrate and pentahydrate of morphine sulphate. They were accompanied by constant values of the differential heats of sorption: –24 kJ mol–1(H2O) for the dihydrate formation and –10 kJ mol–1(H2O) for the pentahydrate formation.
The calorimetrically obtained sorption isotherms were compared with the results of Karl Fisher titrations of morphine sulphate samples equilibrated at different water activities. The appearance of a liquid phase in the morphine sulphate at high water activities is discussed on the basis of the obtained differential heats of sorption and measured heat capacities of morphine sulphate at different water activities. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1034495
- author
- Markova, N and Wadsö, Lars LU
- organization
- publishing date
- 1999
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Thermal Analysis and Calorimetry
- volume
- 57
- issue
- 1
- pages
- 133 - 137
- publisher
- Akademiai Kiado
- external identifiers
-
- scopus:0032595515
- ISSN
- 1588-2926
- DOI
- 10.1023/A:1010166013177
- language
- English
- LU publication?
- yes
- id
- 0a1a70bb-8e81-4078-81c5-03fa4716fdca (old id 1034495)
- date added to LUP
- 2016-04-01 12:36:35
- date last changed
- 2022-01-27 07:22:59
@article{0a1a70bb-8e81-4078-81c5-03fa4716fdca,
abstract = {{Water vapor sorption on morphine sulphate was studied in a twin double sorption microcalorimeter at 25°C. The vapor sorption isotherm and the differential heats of sorption were determined simultaneously from dry condition to a water activity of 0.99. Two well resolved hydration steps were obtained on the sorption isotherm at water activities of 0.01 and 0.22 corresponding to the formation of dihydrate and pentahydrate of morphine sulphate. They were accompanied by constant values of the differential heats of sorption: –24 kJ mol–1(H2O) for the dihydrate formation and –10 kJ mol–1(H2O) for the pentahydrate formation.<br/><br>
The calorimetrically obtained sorption isotherms were compared with the results of Karl Fisher titrations of morphine sulphate samples equilibrated at different water activities. The appearance of a liquid phase in the morphine sulphate at high water activities is discussed on the basis of the obtained differential heats of sorption and measured heat capacities of morphine sulphate at different water activities.}},
author = {{Markova, N and Wadsö, Lars}},
issn = {{1588-2926}},
language = {{eng}},
number = {{1}},
pages = {{133--137}},
publisher = {{Akademiai Kiado}},
series = {{Journal of Thermal Analysis and Calorimetry}},
title = {{A microcalorimetric study of water vapor sorption on morphine sulphate}},
url = {{http://dx.doi.org/10.1023/A:1010166013177}},
doi = {{10.1023/A:1010166013177}},
volume = {{57}},
year = {{1999}},
}