Prognostic implications of BCL6 rearrangement in uniformly treated patients with diffuse large B-cell lymphoma--a Nordic Lymphoma Group study.
(2002) In International Journal of Oncology 20(1). p.161-165- Abstract
- The purpose of this study was to investigate the prognostic implications of BCL6 rearrangement in a uniformly treated population of patients with diffuse large B-cell lymphoma (DLBCL) and to characterise the relationship between BCL6 rearrangement and prognostic factors. A total of 269 patients with DLBCL entered a randomised trial comparing the chemotherapy regimen CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) to the MACOP-B (methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, bleomycin) regimen. In 44 cases, frozen tissue was available for assessment of BCL6 status by Southern blot analysis. BCL6 was rearranged in six of 43 evaluable cases (14%), and was associated with elevated lactate dehydrogenase... (More)
- The purpose of this study was to investigate the prognostic implications of BCL6 rearrangement in a uniformly treated population of patients with diffuse large B-cell lymphoma (DLBCL) and to characterise the relationship between BCL6 rearrangement and prognostic factors. A total of 269 patients with DLBCL entered a randomised trial comparing the chemotherapy regimen CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) to the MACOP-B (methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, bleomycin) regimen. In 44 cases, frozen tissue was available for assessment of BCL6 status by Southern blot analysis. BCL6 was rearranged in six of 43 evaluable cases (14%), and was associated with elevated lactate dehydrogenase (LDH), and a higher patient age. No association between BCL6 status and expression of BCL2, Ki-67 or TP53 was found. Patients presenting with BCL6 rearrangement displayed a weak trend towards better overall and failure-free survival (67 and 67% at 5 years), compared to patients with germline BCL6 (63 and 52%), but the difference was not statistically significant. In accordance with previously published series, the presence of BCL6 rearrangement does not define a prognostically distinct subgroup of DLBCL. Assessment of BCL6 status may, however, be of clinical interest when related to other prognostic variables. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/107004
- author
- Jerkeman, Mats LU ; Aman, P ; Cavallin-Ståhl, Eva LU ; Torlakovic, E ; Åkerman, Måns LU ; Mitelman, Felix LU and Fioretos, Thoas LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Gene Rearrangement B-Lymphocyte : genetics, Human, Immunophenotyping, Lymphoma B-Cell : drug therapy : genetics, Leucovorin : therapeutic use, Lactate Dehydrogenase : metabolism, Lymphoma Large-Cell Diffuse : drug therapy : genetics, Male, Methotrexate : therapeutic use, Middle Age, Neoplasm Staging, Prednisone : therapeutic use, Prognosis, Proto-Oncogene Proteins : genetics, Support Non-U.S. Gov't, Vincristine : therapeutic use, Transcription Factors : genetics, Doxorubicin : therapeutic use, DNA-Binding Proteins : genetics, DNA Neoplasm : analysis : metabolism, Cyclophosphamide : therapeutic use, Blotting Southern, Bleomycin : therapeutic use, Antineoplastic Combined Chemotherapy Protocols : therapeutic use, Aged, Adolescence, Adult
- in
- International Journal of Oncology
- volume
- 20
- issue
- 1
- pages
- 161 - 165
- publisher
- Spandidos Publications
- external identifiers
-
- wos:000172916500023
- pmid:11743658
- scopus:0036133890
- ISSN
- 1019-6439
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Division of Clinical Genetics (013022003), Oncology, MV (013035000)
- id
- dd3c1cf3-397d-4d51-9756-a22b261e6272 (old id 107004)
- alternative location
- http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11743658
- http://147.52.72.117/IJO/2002/volume20/number1/161-165.pdf
- date added to LUP
- 2016-04-01 15:36:42
- date last changed
- 2022-05-08 04:32:18
@article{dd3c1cf3-397d-4d51-9756-a22b261e6272, abstract = {{The purpose of this study was to investigate the prognostic implications of BCL6 rearrangement in a uniformly treated population of patients with diffuse large B-cell lymphoma (DLBCL) and to characterise the relationship between BCL6 rearrangement and prognostic factors. A total of 269 patients with DLBCL entered a randomised trial comparing the chemotherapy regimen CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) to the MACOP-B (methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, bleomycin) regimen. In 44 cases, frozen tissue was available for assessment of BCL6 status by Southern blot analysis. BCL6 was rearranged in six of 43 evaluable cases (14%), and was associated with elevated lactate dehydrogenase (LDH), and a higher patient age. No association between BCL6 status and expression of BCL2, Ki-67 or TP53 was found. Patients presenting with BCL6 rearrangement displayed a weak trend towards better overall and failure-free survival (67 and 67% at 5 years), compared to patients with germline BCL6 (63 and 52%), but the difference was not statistically significant. In accordance with previously published series, the presence of BCL6 rearrangement does not define a prognostically distinct subgroup of DLBCL. Assessment of BCL6 status may, however, be of clinical interest when related to other prognostic variables.}}, author = {{Jerkeman, Mats and Aman, P and Cavallin-Ståhl, Eva and Torlakovic, E and Åkerman, Måns and Mitelman, Felix and Fioretos, Thoas}}, issn = {{1019-6439}}, keywords = {{Gene Rearrangement B-Lymphocyte : genetics; Human; Immunophenotyping; Lymphoma B-Cell : drug therapy : genetics; Leucovorin : therapeutic use; Lactate Dehydrogenase : metabolism; Lymphoma Large-Cell Diffuse : drug therapy : genetics; Male; Methotrexate : therapeutic use; Middle Age; Neoplasm Staging; Prednisone : therapeutic use; Prognosis; Proto-Oncogene Proteins : genetics; Support Non-U.S. Gov't; Vincristine : therapeutic use; Transcription Factors : genetics; Doxorubicin : therapeutic use; DNA-Binding Proteins : genetics; DNA Neoplasm : analysis : metabolism; Cyclophosphamide : therapeutic use; Blotting Southern; Bleomycin : therapeutic use; Antineoplastic Combined Chemotherapy Protocols : therapeutic use; Aged; Adolescence; Adult}}, language = {{eng}}, number = {{1}}, pages = {{161--165}}, publisher = {{Spandidos Publications}}, series = {{International Journal of Oncology}}, title = {{Prognostic implications of BCL6 rearrangement in uniformly treated patients with diffuse large B-cell lymphoma--a Nordic Lymphoma Group study.}}, url = {{http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11743658}}, volume = {{20}}, year = {{2002}}, }