IgM antibody to the hepatitis B core antigen in acute hepatitis determined by SPRIA--diagnostic value
(1982) In Acta pathologica, microbiologica, et immunologica Scandinavica. Section B, Microbiology 90(1). p.79-84- Abstract
- A solid phase radio-immunoassay (SPRIA) was developed for the detection of anti-HBc IgM. The assay proved sensitive and easy to perform and rheumatoid factor did not affect the test results. Anti-HBc IgM titres were followed in consecutive samples from 15 patients after uncomplicated acute hepatitis B. In the acute phase anti-HBc IgM titres ranged from 10(-5) to 10(-7) (mean 10(-6.4)). One year after onset of disease ten of the 15 had titres below 10(-4) and between two and three years after onset most patients had titres 10(-3). Anti-HBc IgM titres were determined in six episodes of acute hepatitis B, all HBsAg negative but anti-HBc positive in the first samples obtained (within 8 days) and developing anti-HBs during convalescence. Acute... (More)
- A solid phase radio-immunoassay (SPRIA) was developed for the detection of anti-HBc IgM. The assay proved sensitive and easy to perform and rheumatoid factor did not affect the test results. Anti-HBc IgM titres were followed in consecutive samples from 15 patients after uncomplicated acute hepatitis B. In the acute phase anti-HBc IgM titres ranged from 10(-5) to 10(-7) (mean 10(-6.4)). One year after onset of disease ten of the 15 had titres below 10(-4) and between two and three years after onset most patients had titres 10(-3). Anti-HBc IgM titres were determined in six episodes of acute hepatitis B, all HBsAg negative but anti-HBc positive in the first samples obtained (within 8 days) and developing anti-HBs during convalescence. Acute phase anti-HBc IgM titres in these patients ranged between 10(-5.5) and 10(-7) (mean 10(-6.5)) and were thus identical with HBsAg positive cases. When acute phase sera from 168 episodes of acute hepatitis primarily classified as non-A, non-B, were tested for anti-HBc IgM titres above 10(-5), sera from 13 episodes were positive and in seven of these hepatitis B diagnosis could be confirmed by rising anti-HBs titres in convalescence. Sera from four of the 13 patients contained HBeAg, which was thus demonstrated in the absence of HBsAg. The results show that testing for anti-HBc IgM is important for a true non-A, non-B diagnosis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1102904
- author
- Widell, Anders LU ; Hansson, B G ; Lofgren, B ; Moestrup, T ; Norkrans, G ; Johnsson, T and Nordenfelt, E
- organization
- publishing date
- 1982
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta pathologica, microbiologica, et immunologica Scandinavica. Section B, Microbiology
- volume
- 90
- issue
- 1
- pages
- 79 - 84
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:7080827
- scopus:0020063843
- ISSN
- 0108-0180
- language
- English
- LU publication?
- yes
- id
- ba86e98e-6026-4731-b4b1-b5f0526953e9 (old id 1102904)
- date added to LUP
- 2016-04-01 16:43:18
- date last changed
- 2021-01-03 10:54:29
@article{ba86e98e-6026-4731-b4b1-b5f0526953e9,
abstract = {{A solid phase radio-immunoassay (SPRIA) was developed for the detection of anti-HBc IgM. The assay proved sensitive and easy to perform and rheumatoid factor did not affect the test results. Anti-HBc IgM titres were followed in consecutive samples from 15 patients after uncomplicated acute hepatitis B. In the acute phase anti-HBc IgM titres ranged from 10(-5) to 10(-7) (mean 10(-6.4)). One year after onset of disease ten of the 15 had titres below 10(-4) and between two and three years after onset most patients had titres 10(-3). Anti-HBc IgM titres were determined in six episodes of acute hepatitis B, all HBsAg negative but anti-HBc positive in the first samples obtained (within 8 days) and developing anti-HBs during convalescence. Acute phase anti-HBc IgM titres in these patients ranged between 10(-5.5) and 10(-7) (mean 10(-6.5)) and were thus identical with HBsAg positive cases. When acute phase sera from 168 episodes of acute hepatitis primarily classified as non-A, non-B, were tested for anti-HBc IgM titres above 10(-5), sera from 13 episodes were positive and in seven of these hepatitis B diagnosis could be confirmed by rising anti-HBs titres in convalescence. Sera from four of the 13 patients contained HBeAg, which was thus demonstrated in the absence of HBsAg. The results show that testing for anti-HBc IgM is important for a true non-A, non-B diagnosis.}},
author = {{Widell, Anders and Hansson, B G and Lofgren, B and Moestrup, T and Norkrans, G and Johnsson, T and Nordenfelt, E}},
issn = {{0108-0180}},
language = {{eng}},
number = {{1}},
pages = {{79--84}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Acta pathologica, microbiologica, et immunologica Scandinavica. Section B, Microbiology}},
title = {{IgM antibody to the hepatitis B core antigen in acute hepatitis determined by SPRIA--diagnostic value}},
volume = {{90}},
year = {{1982}},
}