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Microwave-induced hyperthermia and ionizing radiation. Preliminary clinical results

Lindholm, C-E ; Kjellén, Elisabeth LU ; Landberg, Torsten LU ; Nilsson, Per LU orcid and Persson, B (1982) In Acta Radiologica: Oncology 21(4). p.241-254
Abstract
The combination of microwave-induced (2450 MHz) hyperthermia and ionizing radiation was used in 7 patients with superficial malignant tumours, which were considered refractory to other therapy. A newly developed heating system was used, allowing for a maintained temperature at the master probe of 42.5 degrees C +/- 0.5 degrees C during 45 min, but temperature measurements at multiple sites showed a marked variation. This preliminary series indicates that the combination of hyperthermia and ionizing radiation may be useful, the response rate (complete or partial) being 8 of 8 evaluable lesions. Even previously heavily irradiated sites responded. Technical improvements are highly needed to allow for controlled heating of any tissue volume.
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Radiologica: Oncology
volume
21
issue
4
pages
241 - 254
publisher
Taylor & Francis
external identifiers
  • pmid:6293267
  • scopus:84907108391
ISSN
0349-652X
DOI
10.3109/02841868209134013
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Oncology, MV (013035000), Emergency medicine/Medicine/Surgery (013240200), Radiation Physics, Lund (013034000)
id
c515124b-a7c2-4289-b3e6-9b3d74e19077 (old id 1102920)
date added to LUP
2016-04-01 16:10:20
date last changed
2021-01-03 07:22:20
@article{c515124b-a7c2-4289-b3e6-9b3d74e19077,
  abstract     = {{The combination of microwave-induced (2450 MHz) hyperthermia and ionizing radiation was used in 7 patients with superficial malignant tumours, which were considered refractory to other therapy. A newly developed heating system was used, allowing for a maintained temperature at the master probe of 42.5 degrees C +/- 0.5 degrees C during 45 min, but temperature measurements at multiple sites showed a marked variation. This preliminary series indicates that the combination of hyperthermia and ionizing radiation may be useful, the response rate (complete or partial) being 8 of 8 evaluable lesions. Even previously heavily irradiated sites responded. Technical improvements are highly needed to allow for controlled heating of any tissue volume.}},
  author       = {{Lindholm, C-E and Kjellén, Elisabeth and Landberg, Torsten and Nilsson, Per and Persson, B}},
  issn         = {{0349-652X}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{241--254}},
  publisher    = {{Taylor & Francis}},
  series       = {{Acta Radiologica: Oncology}},
  title        = {{Microwave-induced hyperthermia and ionizing radiation. Preliminary clinical results}},
  url          = {{http://dx.doi.org/10.3109/02841868209134013}},
  doi          = {{10.3109/02841868209134013}},
  volume       = {{21}},
  year         = {{1982}},
}