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Blood group specific oligosaccharides from faeces of a blood group A breast-fed infant

Sabharwal, H ; Nilsson, B ; Chester, Alan LU ; Sjöblad, Sture LU and Lundblad, A (1984) In Molecular Immunology 21(11). p.1105-1112
Abstract
Four different oligosaccharides were isolated from faeces collected from a blood group A, secretor, breast-fed infant. Three of these, GalNAc alpha 1-3[Fuc alpha 1-2]Gal beta 1-4Glc (A-tetrasaccharide), GalNAc alpha 1-3[Fuc alpha 1-2]Gal beta 1-4[Fuc alpha 1-3]Glc (A-pentasaccharide) and 1-3[Fuc alpha 1-4]GlcNAc beta 1-3Gal beta 1-4Glc (A-heptasaccharide) have previously found in urine, whereas GalNAc alpha 1-3[Fuc alpha 1-2]Gal beta 1-3GlcNAc beta 1-3Gal beta 1-4Glc (A-hexasaccharide) is a new compound. Structures were deduced by mass spectrometry of permethylated and N-trifluoroacetylated oligosaccharide alditols. The latter gave more structural information than the corresponding N-acetyl derivatives. The four oligosaccharides were... (More)
Four different oligosaccharides were isolated from faeces collected from a blood group A, secretor, breast-fed infant. Three of these, GalNAc alpha 1-3[Fuc alpha 1-2]Gal beta 1-4Glc (A-tetrasaccharide), GalNAc alpha 1-3[Fuc alpha 1-2]Gal beta 1-4[Fuc alpha 1-3]Glc (A-pentasaccharide) and 1-3[Fuc alpha 1-4]GlcNAc beta 1-3Gal beta 1-4Glc (A-heptasaccharide) have previously found in urine, whereas GalNAc alpha 1-3[Fuc alpha 1-2]Gal beta 1-3GlcNAc beta 1-3Gal beta 1-4Glc (A-hexasaccharide) is a new compound. Structures were deduced by mass spectrometry of permethylated and N-trifluoroacetylated oligosaccharide alditols. The latter gave more structural information than the corresponding N-acetyl derivatives. The four oligosaccharides were tested for blood group A activity and all were found to inhibit the binding of anti-A antibody to blood group A substance. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Molecular Immunology
volume
21
issue
11
pages
1105 - 1112
publisher
Pergamon Press Ltd.
external identifiers
  • pmid:6513935
  • scopus:0021680739
ISSN
1872-9142
DOI
10.1016/0161-5890(84)90121-4
language
English
LU publication?
yes
id
bf0ad4ed-13eb-4b0a-8e14-420ef1b0274a (old id 1103202)
date added to LUP
2016-04-01 16:22:31
date last changed
2021-01-03 10:01:10
@article{bf0ad4ed-13eb-4b0a-8e14-420ef1b0274a,
  abstract     = {{Four different oligosaccharides were isolated from faeces collected from a blood group A, secretor, breast-fed infant. Three of these, GalNAc alpha 1-3[Fuc alpha 1-2]Gal beta 1-4Glc (A-tetrasaccharide), GalNAc alpha 1-3[Fuc alpha 1-2]Gal beta 1-4[Fuc alpha 1-3]Glc (A-pentasaccharide) and 1-3[Fuc alpha 1-4]GlcNAc beta 1-3Gal beta 1-4Glc (A-heptasaccharide) have previously found in urine, whereas GalNAc alpha 1-3[Fuc alpha 1-2]Gal beta 1-3GlcNAc beta 1-3Gal beta 1-4Glc (A-hexasaccharide) is a new compound. Structures were deduced by mass spectrometry of permethylated and N-trifluoroacetylated oligosaccharide alditols. The latter gave more structural information than the corresponding N-acetyl derivatives. The four oligosaccharides were tested for blood group A activity and all were found to inhibit the binding of anti-A antibody to blood group A substance.}},
  author       = {{Sabharwal, H and Nilsson, B and Chester, Alan and Sjöblad, Sture and Lundblad, A}},
  issn         = {{1872-9142}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{1105--1112}},
  publisher    = {{Pergamon Press Ltd.}},
  series       = {{Molecular Immunology}},
  title        = {{Blood group specific oligosaccharides from faeces of a blood group A breast-fed infant}},
  url          = {{http://dx.doi.org/10.1016/0161-5890(84)90121-4}},
  doi          = {{10.1016/0161-5890(84)90121-4}},
  volume       = {{21}},
  year         = {{1984}},
}