The influence of treatment with estrogens and estramustine phosphate on platelet aggregation and plasma lipoproteins in non-disseminated prostatic carcinoma
(1984) In Journal of Urology 132(5). p.1021-1024- Abstract
- The treatment of prostatic carcinoma with estrogens is associated with an increased risk of cardiovascular as well as thromboembolic complications. In the present study, patients harboring highly or moderately differentiated prostatic carcinoma without signs of metastases were treated with either polyestradiolphosphate + etinylestradiol, estramustine phosphate or given no treatment. Subsequently, these patients were investigated regarding factors (platelet aggregation, plasma and platelet phospholipid composition and lipoprotein patterns) that might contribute to increased thrombogenesis and cardiovascular risk. The results indicate the presence of increased in vitro platelet aggregation in patients treated with polyestradiolphosphate +... (More)
- The treatment of prostatic carcinoma with estrogens is associated with an increased risk of cardiovascular as well as thromboembolic complications. In the present study, patients harboring highly or moderately differentiated prostatic carcinoma without signs of metastases were treated with either polyestradiolphosphate + etinylestradiol, estramustine phosphate or given no treatment. Subsequently, these patients were investigated regarding factors (platelet aggregation, plasma and platelet phospholipid composition and lipoprotein patterns) that might contribute to increased thrombogenesis and cardiovascular risk. The results indicate the presence of increased in vitro platelet aggregation in patients treated with polyestradiolphosphate + etinylestradiol compared to those treated with estramustine phosphate or given no treatment. A possible relationship between the availability of arachidonic acid in platelet membrane phospholipids and in vitro platelet aggregation is suggested. On the other hand the alterations in plasma lipoproteins observed during treatment are generally considered positive from an atherogenic point of view and do not seem relevant to the elevated incidence of cardiovascular disease in these patients. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1103237
- author
- Agardh, Carl-David LU ; Nilsson-Ehle, Peter LU ; Lundgren, R and Gustafson, A
- organization
- publishing date
- 1984
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Urology
- volume
- 132
- issue
- 5
- pages
- 1021 - 1024
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:6492270
- scopus:0021124969
- ISSN
- 1527-3792
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Clinical Chemistry and Pharmacology (013250300), Unit on Vascular Diabetic Complications (013241510)
- id
- c828d8fe-3320-4335-a041-d60f83f38fde (old id 1103237)
- date added to LUP
- 2016-04-01 17:14:11
- date last changed
- 2021-01-03 05:55:01
@article{c828d8fe-3320-4335-a041-d60f83f38fde, abstract = {{The treatment of prostatic carcinoma with estrogens is associated with an increased risk of cardiovascular as well as thromboembolic complications. In the present study, patients harboring highly or moderately differentiated prostatic carcinoma without signs of metastases were treated with either polyestradiolphosphate + etinylestradiol, estramustine phosphate or given no treatment. Subsequently, these patients were investigated regarding factors (platelet aggregation, plasma and platelet phospholipid composition and lipoprotein patterns) that might contribute to increased thrombogenesis and cardiovascular risk. The results indicate the presence of increased in vitro platelet aggregation in patients treated with polyestradiolphosphate + etinylestradiol compared to those treated with estramustine phosphate or given no treatment. A possible relationship between the availability of arachidonic acid in platelet membrane phospholipids and in vitro platelet aggregation is suggested. On the other hand the alterations in plasma lipoproteins observed during treatment are generally considered positive from an atherogenic point of view and do not seem relevant to the elevated incidence of cardiovascular disease in these patients.}}, author = {{Agardh, Carl-David and Nilsson-Ehle, Peter and Lundgren, R and Gustafson, A}}, issn = {{1527-3792}}, language = {{eng}}, number = {{5}}, pages = {{1021--1024}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{Journal of Urology}}, title = {{The influence of treatment with estrogens and estramustine phosphate on platelet aggregation and plasma lipoproteins in non-disseminated prostatic carcinoma}}, volume = {{132}}, year = {{1984}}, }