Influence of standard heparin or low molecular weight heparin on healing of abdominal wounds and colonic anastomoses in rats
(1987) In Acta Chirurgica Scandinavica 153(10). p.593-598- Abstract
- The influence of standard heparin or low molecular weight (LMW) heparin on healing of abdominal wounds and colonic anastomoses was studied in rats. Subcutaneous injection of 1 XaI U/g b.w. of standard or LMW-heparin or 0.5 ml physiologic saline was given 12 hours preoperatively and daily for 3 or 7 days postoperatively. Breaking strength of the abdominal wound and the anastomosis was measured, as were haemoglobin and albumin in serum. Hydroxyproline as a measure of collagen and tissue dry weight was determined in standardized segments of colonic wall adjacent to the anastomosis. Except for significant increase in breaking strength of the anastomosis after 7-day injection of LMW heparin, no differences in the parameters of wound healing... (More)
- The influence of standard heparin or low molecular weight (LMW) heparin on healing of abdominal wounds and colonic anastomoses was studied in rats. Subcutaneous injection of 1 XaI U/g b.w. of standard or LMW-heparin or 0.5 ml physiologic saline was given 12 hours preoperatively and daily for 3 or 7 days postoperatively. Breaking strength of the abdominal wound and the anastomosis was measured, as were haemoglobin and albumin in serum. Hydroxyproline as a measure of collagen and tissue dry weight was determined in standardized segments of colonic wall adjacent to the anastomosis. Except for significant increase in breaking strength of the anastomosis after 7-day injection of LMW heparin, no differences in the parameters of wound healing were found after 3 or 7 days. In rats receiving standard heparin there was increased bleeding tendency (reduced haemoglobin) compared with the LMW-heparin group and the controls. The administered heparin thus did not negatively influence healing, and standard and LMW-heparin did not differ in this respect. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1103886
- author
- Mätzsch, Thomas LU ; Bergqvist, D ; Blomquist, Peter LU and Jiborn, H
- organization
- publishing date
- 1987
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Chirurgica Scandinavica
- volume
- 153
- issue
- 10
- pages
- 593 - 598
- publisher
- Almqvist & Wiksell
- external identifiers
-
- pmid:2829481
- scopus:0023518634
- ISSN
- 0001-5482
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Surgery Research Unit (013242220)
- id
- d08aae04-a5d3-4b1d-beb9-3a4d32d2e04b (old id 1103886)
- date added to LUP
- 2016-04-01 17:07:32
- date last changed
- 2021-01-03 07:58:54
@article{d08aae04-a5d3-4b1d-beb9-3a4d32d2e04b, abstract = {{The influence of standard heparin or low molecular weight (LMW) heparin on healing of abdominal wounds and colonic anastomoses was studied in rats. Subcutaneous injection of 1 XaI U/g b.w. of standard or LMW-heparin or 0.5 ml physiologic saline was given 12 hours preoperatively and daily for 3 or 7 days postoperatively. Breaking strength of the abdominal wound and the anastomosis was measured, as were haemoglobin and albumin in serum. Hydroxyproline as a measure of collagen and tissue dry weight was determined in standardized segments of colonic wall adjacent to the anastomosis. Except for significant increase in breaking strength of the anastomosis after 7-day injection of LMW heparin, no differences in the parameters of wound healing were found after 3 or 7 days. In rats receiving standard heparin there was increased bleeding tendency (reduced haemoglobin) compared with the LMW-heparin group and the controls. The administered heparin thus did not negatively influence healing, and standard and LMW-heparin did not differ in this respect.}}, author = {{Mätzsch, Thomas and Bergqvist, D and Blomquist, Peter and Jiborn, H}}, issn = {{0001-5482}}, language = {{eng}}, number = {{10}}, pages = {{593--598}}, publisher = {{Almqvist & Wiksell}}, series = {{Acta Chirurgica Scandinavica}}, title = {{Influence of standard heparin or low molecular weight heparin on healing of abdominal wounds and colonic anastomoses in rats}}, volume = {{153}}, year = {{1987}}, }