Increase in hepatic lipase activity after testosterone substitution in men with hypogonadism of pituitary origin
(1987) In Acta Medica Scandinavica 221(4). p.363-366- Abstract
- Ten men with hypogonadism of pituitary origin were studied before and during testosterone substitution therapy with regard to effects on the activities of hepatic lipase (HL) and lipoprotein lipase (LPL) in postheparin plasma, and on plasma lipoprotein concentrations. The mean (+/- SEM) testosterone level increased from 1.8 +/- 0.5 to 16.3 +/- 2.4 nmol/l. The mean activity of HL rose from 327.1 +/- 35.2 to 432.8 +/- 57.2 mU/ml (p less than 0.02), while the activity of LPL did not change significantly, 71.0 +/- 9.1 mU/ml before and 62.2 +/- 3.8 mU/ml after treatment. No significant alterations in lipoprotein concentrations were recorded. These results indicate that a normal testosterone level is of importance for maintaining the activity of... (More)
- Ten men with hypogonadism of pituitary origin were studied before and during testosterone substitution therapy with regard to effects on the activities of hepatic lipase (HL) and lipoprotein lipase (LPL) in postheparin plasma, and on plasma lipoprotein concentrations. The mean (+/- SEM) testosterone level increased from 1.8 +/- 0.5 to 16.3 +/- 2.4 nmol/l. The mean activity of HL rose from 327.1 +/- 35.2 to 432.8 +/- 57.2 mU/ml (p less than 0.02), while the activity of LPL did not change significantly, 71.0 +/- 9.1 mU/ml before and 62.2 +/- 3.8 mU/ml after treatment. No significant alterations in lipoprotein concentrations were recorded. These results indicate that a normal testosterone level is of importance for maintaining the activity of HL in men, thereby contributing to the sex difference previously recorded for HL activity. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1103965
- author
- Valdemarsson, Stig LU ; Hedner, P and Nilsson-Ehle, Peter LU
- organization
- publishing date
- 1987
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Medica Scandinavica
- volume
- 221
- issue
- 4
- pages
- 363 - 366
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:3604752
- scopus:0023227651
- ISSN
- 0001-6101
- language
- English
- LU publication?
- yes
- id
- cdabe99f-a43f-4214-8248-bd41f772cffb (old id 1103965)
- date added to LUP
- 2016-04-01 15:53:12
- date last changed
- 2024-01-10 21:32:38
@article{cdabe99f-a43f-4214-8248-bd41f772cffb, abstract = {{Ten men with hypogonadism of pituitary origin were studied before and during testosterone substitution therapy with regard to effects on the activities of hepatic lipase (HL) and lipoprotein lipase (LPL) in postheparin plasma, and on plasma lipoprotein concentrations. The mean (+/- SEM) testosterone level increased from 1.8 +/- 0.5 to 16.3 +/- 2.4 nmol/l. The mean activity of HL rose from 327.1 +/- 35.2 to 432.8 +/- 57.2 mU/ml (p less than 0.02), while the activity of LPL did not change significantly, 71.0 +/- 9.1 mU/ml before and 62.2 +/- 3.8 mU/ml after treatment. No significant alterations in lipoprotein concentrations were recorded. These results indicate that a normal testosterone level is of importance for maintaining the activity of HL in men, thereby contributing to the sex difference previously recorded for HL activity.}}, author = {{Valdemarsson, Stig and Hedner, P and Nilsson-Ehle, Peter}}, issn = {{0001-6101}}, language = {{eng}}, number = {{4}}, pages = {{363--366}}, publisher = {{Wiley-Blackwell}}, series = {{Acta Medica Scandinavica}}, title = {{Increase in hepatic lipase activity after testosterone substitution in men with hypogonadism of pituitary origin}}, volume = {{221}}, year = {{1987}}, }