The 5-hydroxytryptamine stimulated formation of inositol phosphate is inhibited in platelets from alcoholics
(1988) In Life Sciences 42(4). p.385-391- Abstract
- The accumulation of inositol monophosphate (IP1) was measured after stimulation of 5-hydroxytryptamine2 (5-HT2) receptors on platelets from alcoholics and healthy controls. In controls, 5-HT induced a dose-dependent response with an EC50 = 2 x 10(-6) M and a maximal response at 10(-5) M. Ritanserin, a selective 5-HT2 antagonist, markedly reduced the accumulation. The IP1 formation after stimulation by 10(-5) M 5-HT was significantly impaired in platelets from alcoholics as compared to controls. This study indicates that the 5-HT2 receptor function is inhibited in alcoholics. It also illustrates the possibility of using IP1 formation in peripheral cells as a mean of studying receptor function in disease.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1104304
- author
- Simonsson, Per LU and Alling, Christer LU
- organization
- publishing date
- 1988
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Life Sciences
- volume
- 42
- issue
- 4
- pages
- 385 - 391
- publisher
- Elsevier
- external identifiers
-
- pmid:3123830
- scopus:0023872391
- ISSN
- 1879-0631
- DOI
- 10.1016/0024-3205(88)90076-8
- language
- English
- LU publication?
- yes
- id
- 8099d7ca-ec10-4b07-8e8f-05b9c5f3a26f (old id 1104304)
- date added to LUP
- 2016-04-01 12:33:39
- date last changed
- 2021-01-03 03:14:06
@article{8099d7ca-ec10-4b07-8e8f-05b9c5f3a26f, abstract = {{The accumulation of inositol monophosphate (IP1) was measured after stimulation of 5-hydroxytryptamine2 (5-HT2) receptors on platelets from alcoholics and healthy controls. In controls, 5-HT induced a dose-dependent response with an EC50 = 2 x 10(-6) M and a maximal response at 10(-5) M. Ritanserin, a selective 5-HT2 antagonist, markedly reduced the accumulation. The IP1 formation after stimulation by 10(-5) M 5-HT was significantly impaired in platelets from alcoholics as compared to controls. This study indicates that the 5-HT2 receptor function is inhibited in alcoholics. It also illustrates the possibility of using IP1 formation in peripheral cells as a mean of studying receptor function in disease.}}, author = {{Simonsson, Per and Alling, Christer}}, issn = {{1879-0631}}, language = {{eng}}, number = {{4}}, pages = {{385--391}}, publisher = {{Elsevier}}, series = {{Life Sciences}}, title = {{The 5-hydroxytryptamine stimulated formation of inositol phosphate is inhibited in platelets from alcoholics}}, url = {{http://dx.doi.org/10.1016/0024-3205(88)90076-8}}, doi = {{10.1016/0024-3205(88)90076-8}}, volume = {{42}}, year = {{1988}}, }