Effects of reduced oxygen tension on endothelium-dependent relaxation induced by acetylcholine differ in rabbit femoral artery and jugular vein
(1989) In Acta Physiologica Scandinavica 135(3). p.343-348- Abstract
- In intact rabbit femoral artery rings pre-contracted with phenylephrine, acetylcholine (ACh; 10(-9)-10(-6) M) produces endothelium-dependent relaxation, abolished after mechanical rubbing to remove the endothelium. The response to ACh was absent at low oxygen tension (less than or equal to 4 kPa) or in the presence of sodium cyanide (1 mM). Intact rabbit jugular veins relaxed to ACh in lower concentration than did the femoral artery, 10(-10)-10(-8) M; at sufficient ACh concentration the relaxation was complete. In veins with completely removed endothelium no relaxation to ACh occurred, and at concentrations above 3 x 10(-7) M the response was a contraction. The relaxation response to ACh of intact veins persisted during contraction at... (More)
- In intact rabbit femoral artery rings pre-contracted with phenylephrine, acetylcholine (ACh; 10(-9)-10(-6) M) produces endothelium-dependent relaxation, abolished after mechanical rubbing to remove the endothelium. The response to ACh was absent at low oxygen tension (less than or equal to 4 kPa) or in the presence of sodium cyanide (1 mM). Intact rabbit jugular veins relaxed to ACh in lower concentration than did the femoral artery, 10(-10)-10(-8) M; at sufficient ACh concentration the relaxation was complete. In veins with completely removed endothelium no relaxation to ACh occurred, and at concentrations above 3 x 10(-7) M the response was a contraction. The relaxation response to ACh of intact veins persisted during contraction at lower oxygen tension or in the presence of 1 mM sodium cyanide. In rubbed veins, cyanide consistently induced a transient contraction, which was absent in intact veins. The study demonstrates pronounced endothelium-dependent relaxation to ACh in a venous preparation, with a markedly lower sensitivity of the relaxation response to hypoxia than in a muscular artery of the same species. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1104642
- author
- Vedernikov, Y P and Hellstrand, Per LU
- organization
- publishing date
- 1989
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Physiologica Scandinavica
- volume
- 135
- issue
- 3
- pages
- 343 - 348
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:2929373
- scopus:0024538794
- ISSN
- 0001-6772
- language
- English
- LU publication?
- yes
- id
- 691513bc-f569-4f46-88ed-8ab292087e11 (old id 1104642)
- date added to LUP
- 2016-04-01 15:18:41
- date last changed
- 2021-01-03 08:03:52
@article{691513bc-f569-4f46-88ed-8ab292087e11,
abstract = {{In intact rabbit femoral artery rings pre-contracted with phenylephrine, acetylcholine (ACh; 10(-9)-10(-6) M) produces endothelium-dependent relaxation, abolished after mechanical rubbing to remove the endothelium. The response to ACh was absent at low oxygen tension (less than or equal to 4 kPa) or in the presence of sodium cyanide (1 mM). Intact rabbit jugular veins relaxed to ACh in lower concentration than did the femoral artery, 10(-10)-10(-8) M; at sufficient ACh concentration the relaxation was complete. In veins with completely removed endothelium no relaxation to ACh occurred, and at concentrations above 3 x 10(-7) M the response was a contraction. The relaxation response to ACh of intact veins persisted during contraction at lower oxygen tension or in the presence of 1 mM sodium cyanide. In rubbed veins, cyanide consistently induced a transient contraction, which was absent in intact veins. The study demonstrates pronounced endothelium-dependent relaxation to ACh in a venous preparation, with a markedly lower sensitivity of the relaxation response to hypoxia than in a muscular artery of the same species.}},
author = {{Vedernikov, Y P and Hellstrand, Per}},
issn = {{0001-6772}},
language = {{eng}},
number = {{3}},
pages = {{343--348}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Physiologica Scandinavica}},
title = {{Effects of reduced oxygen tension on endothelium-dependent relaxation induced by acetylcholine differ in rabbit femoral artery and jugular vein}},
volume = {{135}},
year = {{1989}},
}