Inhibition of cerebrospinal fluid formation by omeprazole
(1992) In Experimental Neurology 115(3). p.394-399- Abstract
- Omeprazole, a specific inhibitor of H(+)-K(+)-activated ATPase, gave a dose-dependent inhibition of CSF production as determined by cerebroventriculocisternal perfusions in the rabbit. The reduction was 35% when the perfusate concentration of omeprazole was 10(-6) M and 25% after an intravenous dose of 0.2 mg/kg of omeprazole, respectively. A similarly substituted benzimidazol (H178/42) without H(+)-K(+)-ATPase-inhibiting properties did not affect CSF production at a perfusate concentration of 10(-5) M. Omeprazole in a concentration of 2 x 10(-4) M and more caused a significant but variable reduction in total and Na(+)-K(+)-ATPase activity in choroid plexus homogenates. However, in concentrations of 2 x 10(-5) M and less, no effect on... (More)
- Omeprazole, a specific inhibitor of H(+)-K(+)-activated ATPase, gave a dose-dependent inhibition of CSF production as determined by cerebroventriculocisternal perfusions in the rabbit. The reduction was 35% when the perfusate concentration of omeprazole was 10(-6) M and 25% after an intravenous dose of 0.2 mg/kg of omeprazole, respectively. A similarly substituted benzimidazol (H178/42) without H(+)-K(+)-ATPase-inhibiting properties did not affect CSF production at a perfusate concentration of 10(-5) M. Omeprazole in a concentration of 2 x 10(-4) M and more caused a significant but variable reduction in total and Na(+)-K(+)-ATPase activity in choroid plexus homogenates. However, in concentrations of 2 x 10(-5) M and less, no effect on total or Na(+)-K(+)-ATPase activity was obtained. Nor did omeprazole (2 x 10(-4) M) influence HCO3-ATPase. Choline uptake in isolated choroid plexus was significantly reduced by 86% in the presence of acid-pretreated omeprazole 2 x 10(-3) M, but was not affected by 2 x 10(-5) M omeprazole (intact or acid-pretreated). Thus, the mechanism for the marked inhibitory influence of omeprazole on CSF production is not yet evident. In doses causing even a 50% reduction of CSF production, no side effects were observed in contrast to Na(+)-K(+)-ATPase inhibitors such as ouabain. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1106661
- author
- Lindvall-Axelsson, Maria ; Nilsson, Christer ; Owman, Christer LU and Winbladh, Birger
- organization
- publishing date
- 1992
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Experimental Neurology
- volume
- 115
- issue
- 3
- pages
- 394 - 399
- publisher
- Elsevier
- external identifiers
-
- pmid:1311267
- scopus:0026519165
- ISSN
- 0014-4886
- DOI
- 10.1016/0014-4886(92)90204-4
- language
- English
- LU publication?
- yes
- id
- 4faa1de1-dcde-4d9f-9f96-80f6a45a65f2 (old id 1106661)
- date added to LUP
- 2016-04-01 12:05:42
- date last changed
- 2021-04-25 05:16:33
@article{4faa1de1-dcde-4d9f-9f96-80f6a45a65f2,
abstract = {{Omeprazole, a specific inhibitor of H(+)-K(+)-activated ATPase, gave a dose-dependent inhibition of CSF production as determined by cerebroventriculocisternal perfusions in the rabbit. The reduction was 35% when the perfusate concentration of omeprazole was 10(-6) M and 25% after an intravenous dose of 0.2 mg/kg of omeprazole, respectively. A similarly substituted benzimidazol (H178/42) without H(+)-K(+)-ATPase-inhibiting properties did not affect CSF production at a perfusate concentration of 10(-5) M. Omeprazole in a concentration of 2 x 10(-4) M and more caused a significant but variable reduction in total and Na(+)-K(+)-ATPase activity in choroid plexus homogenates. However, in concentrations of 2 x 10(-5) M and less, no effect on total or Na(+)-K(+)-ATPase activity was obtained. Nor did omeprazole (2 x 10(-4) M) influence HCO3-ATPase. Choline uptake in isolated choroid plexus was significantly reduced by 86% in the presence of acid-pretreated omeprazole 2 x 10(-3) M, but was not affected by 2 x 10(-5) M omeprazole (intact or acid-pretreated). Thus, the mechanism for the marked inhibitory influence of omeprazole on CSF production is not yet evident. In doses causing even a 50% reduction of CSF production, no side effects were observed in contrast to Na(+)-K(+)-ATPase inhibitors such as ouabain.}},
author = {{Lindvall-Axelsson, Maria and Nilsson, Christer and Owman, Christer and Winbladh, Birger}},
issn = {{0014-4886}},
language = {{eng}},
number = {{3}},
pages = {{394--399}},
publisher = {{Elsevier}},
series = {{Experimental Neurology}},
title = {{Inhibition of cerebrospinal fluid formation by omeprazole}},
url = {{http://dx.doi.org/10.1016/0014-4886(92)90204-4}},
doi = {{10.1016/0014-4886(92)90204-4}},
volume = {{115}},
year = {{1992}},
}