Glibenclamide and L-NG-nitro-arginine methyl ester modulate the ocular and hypotensive effects of calcitonin gene-related peptide
(1992) In European Journal of Pharmacology 224(1). p.89-91- Abstract
- Calcitonin gene-related peptide (CGRP) given i.v. to rabbits induced hypotension and a breakdown of the blood-aqueous barrier. Glibenclamide, a blocker of ATP-sensitive K+ (K+ATP) channels antagonized both these effects. The K+ATP channel opener diazoxide reduced blood pressure but did not damage the blood-aqueous barrier. Inhibition of nitric oxide synthase antagonized the effects of CGRP on the blood-aqueous barrier but did not attenuate the hypotensive response. The results suggest that vasodilatation induced by the opening of K+ATP channels is a prerequisite for the effect of CGRP on the blood-aqueous barrier.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1106913
- author
- Andersson, Sven LU
- organization
- publishing date
- 1992
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- K+ channels (ATP-sensitive), Blood-aqueous barrier, Nitric oxide (NO), Vasodilatation
- in
- European Journal of Pharmacology
- volume
- 224
- issue
- 1
- pages
- 89 - 91
- publisher
- Elsevier
- external identifiers
-
- pmid:1280598
- scopus:0026615277
- ISSN
- 1879-0712
- DOI
- 10.1016/0014-2999(92)94823-E
- language
- English
- LU publication?
- yes
- id
- 65d68ba5-d10f-4d3f-be37-ba76ff6e78f7 (old id 1106913)
- date added to LUP
- 2016-04-01 11:41:12
- date last changed
- 2024-01-07 16:36:11
@article{65d68ba5-d10f-4d3f-be37-ba76ff6e78f7, abstract = {{Calcitonin gene-related peptide (CGRP) given i.v. to rabbits induced hypotension and a breakdown of the blood-aqueous barrier. Glibenclamide, a blocker of ATP-sensitive K+ (K+ATP) channels antagonized both these effects. The K+ATP channel opener diazoxide reduced blood pressure but did not damage the blood-aqueous barrier. Inhibition of nitric oxide synthase antagonized the effects of CGRP on the blood-aqueous barrier but did not attenuate the hypotensive response. The results suggest that vasodilatation induced by the opening of K+ATP channels is a prerequisite for the effect of CGRP on the blood-aqueous barrier.}}, author = {{Andersson, Sven}}, issn = {{1879-0712}}, keywords = {{K+ channels (ATP-sensitive); Blood-aqueous barrier; Nitric oxide (NO); Vasodilatation}}, language = {{eng}}, number = {{1}}, pages = {{89--91}}, publisher = {{Elsevier}}, series = {{European Journal of Pharmacology}}, title = {{Glibenclamide and L-NG-nitro-arginine methyl ester modulate the ocular and hypotensive effects of calcitonin gene-related peptide}}, url = {{http://dx.doi.org/10.1016/0014-2999(92)94823-E}}, doi = {{10.1016/0014-2999(92)94823-E}}, volume = {{224}}, year = {{1992}}, }