T3N0 glottic carcinoma: DNA S-phase as a predictor of the outcome after radiotherapy
(1993) In Acta Oto-Laryngologica 113(1). p.220-224- Abstract
- In consecutive series of 326 laryngeal cancer patients, of 29 (9%) with stage T3N0 glottic carcinomas, 23 achieved complete local remission after curative radiotherapy and form the basis of the present investigation. Flow cytometry determinations of DNA-ploidy status and the S-phase fraction, and a "histopathological malignancy grading system" were evaluated as possible patient- and/or tumor-related predictors of local recurrence. Twelve patients (52%) were continuously disease-free after radiotherapy, whereas 10 (43%) manifested local recurrence, and one distant metastasis. The radiotherapy delivered to patients who later suffered from a local recurrence did not differ from those being continuously disease-free. The frequency of local... (More)
- In consecutive series of 326 laryngeal cancer patients, of 29 (9%) with stage T3N0 glottic carcinomas, 23 achieved complete local remission after curative radiotherapy and form the basis of the present investigation. Flow cytometry determinations of DNA-ploidy status and the S-phase fraction, and a "histopathological malignancy grading system" were evaluated as possible patient- and/or tumor-related predictors of local recurrence. Twelve patients (52%) were continuously disease-free after radiotherapy, whereas 10 (43%) manifested local recurrence, and one distant metastasis. The radiotherapy delivered to patients who later suffered from a local recurrence did not differ from those being continuously disease-free. The frequency of local recurrence was significantly correlated to patients whose primary tumours manifested a low S-phase fraction (p < 0.05). A low S-phase fraction may indicate slowly proliferating tumour-cells, which become more radioresistant on exposure to a series of fractionated doses, as their reassortment into sensitive phases will be proportionately slower. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1107049
- author
- Tennvall, Jan LU ; Wennerberg, Johan LU ; Willen, R ; Ask, Anders LU ; Baldetorp, Bo LU and Fernö, Mårten LU
- organization
- publishing date
- 1993
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- laryngeal carcinoma, recurrence, proliferation, flow cytometry, hisroparhological grading system
- in
- Acta Oto-Laryngologica
- volume
- 113
- issue
- 1
- pages
- 220 - 224
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:8475740
- scopus:0027526506
- ISSN
- 1651-2251
- DOI
- 10.3109/00016489309135796
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Otorhinolaryngology (Lund) (013044000), Oncology, MV (013035000)
- id
- f8009b21-b518-4241-ab77-e6d7bceb0543 (old id 1107049)
- date added to LUP
- 2016-04-01 16:16:58
- date last changed
- 2021-01-03 08:34:30
@article{f8009b21-b518-4241-ab77-e6d7bceb0543, abstract = {{In consecutive series of 326 laryngeal cancer patients, of 29 (9%) with stage T3N0 glottic carcinomas, 23 achieved complete local remission after curative radiotherapy and form the basis of the present investigation. Flow cytometry determinations of DNA-ploidy status and the S-phase fraction, and a "histopathological malignancy grading system" were evaluated as possible patient- and/or tumor-related predictors of local recurrence. Twelve patients (52%) were continuously disease-free after radiotherapy, whereas 10 (43%) manifested local recurrence, and one distant metastasis. The radiotherapy delivered to patients who later suffered from a local recurrence did not differ from those being continuously disease-free. The frequency of local recurrence was significantly correlated to patients whose primary tumours manifested a low S-phase fraction (p < 0.05). A low S-phase fraction may indicate slowly proliferating tumour-cells, which become more radioresistant on exposure to a series of fractionated doses, as their reassortment into sensitive phases will be proportionately slower.}}, author = {{Tennvall, Jan and Wennerberg, Johan and Willen, R and Ask, Anders and Baldetorp, Bo and Fernö, Mårten}}, issn = {{1651-2251}}, keywords = {{laryngeal carcinoma; recurrence; proliferation; flow cytometry; hisroparhological grading system}}, language = {{eng}}, number = {{1}}, pages = {{220--224}}, publisher = {{Taylor & Francis}}, series = {{Acta Oto-Laryngologica}}, title = {{T3N0 glottic carcinoma: DNA S-phase as a predictor of the outcome after radiotherapy}}, url = {{http://dx.doi.org/10.3109/00016489309135796}}, doi = {{10.3109/00016489309135796}}, volume = {{113}}, year = {{1993}}, }