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Local host response in the lower respiratory tract in nephropathia epidemica

Linderholm, Mats ; Bjermer, Leif LU ; Juto, Per ; Roos, Göran ; Sandstrom, Thomas ; Settergren, Bo and Tarnvik, Arne (1993) In Scandinavian Journal of Infectious Diseases 25(5). p.639-646
Abstract
Various lines of evidence suggest a respiratory route of transmission of nephropathia epidemica (NE). To study the response of the respiratory tract in NE, fiberoptic bronchoscopy with bronchoalveolar lavage (BAL) was performed in 5 patients in the acute phase of the disease. Compared to a reference group of 15 healthy individuals, BAL fluid of NE patients contained significantly higher total numbers of cells (p < 0.05) and significantly higher numbers of lysozyme-positive macrophages (p < 0.01), CD8+ T cells (p < 0.01), and natural killer (NK) cells (p < 0.01). There was no significant difference in numbers of CD4+ T cells, B cells, or neutrophils. When blood samples of 16 patients were examined at various intervals after... (More)
Various lines of evidence suggest a respiratory route of transmission of nephropathia epidemica (NE). To study the response of the respiratory tract in NE, fiberoptic bronchoscopy with bronchoalveolar lavage (BAL) was performed in 5 patients in the acute phase of the disease. Compared to a reference group of 15 healthy individuals, BAL fluid of NE patients contained significantly higher total numbers of cells (p < 0.05) and significantly higher numbers of lysozyme-positive macrophages (p < 0.01), CD8+ T cells (p < 0.01), and natural killer (NK) cells (p < 0.01). There was no significant difference in numbers of CD4+ T cells, B cells, or neutrophils. When blood samples of 16 patients were examined at various intervals after onset of NE, a significant decrease in the number of NK cells (p < 0.01) was found in the acute phase of the disease. The findings are compatible with the presence of a local host response in the lower respiratory tract to NE virus infection. (Less)
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Infectious Diseases
volume
25
issue
5
pages
639 - 646
publisher
Informa Healthcare
external identifiers
  • pmid:7904380
  • scopus:0027424836
ISSN
1651-1980
DOI
10.3109/00365549309008554
language
English
LU publication?
yes
id
d6afe053-cda9-44db-972d-206c16e20c58 (old id 1107087)
date added to LUP
2016-04-01 16:55:59
date last changed
2021-03-28 03:24:48
@article{d6afe053-cda9-44db-972d-206c16e20c58,
  abstract     = {{Various lines of evidence suggest a respiratory route of transmission of nephropathia epidemica (NE). To study the response of the respiratory tract in NE, fiberoptic bronchoscopy with bronchoalveolar lavage (BAL) was performed in 5 patients in the acute phase of the disease. Compared to a reference group of 15 healthy individuals, BAL fluid of NE patients contained significantly higher total numbers of cells (p &lt; 0.05) and significantly higher numbers of lysozyme-positive macrophages (p &lt; 0.01), CD8+ T cells (p &lt; 0.01), and natural killer (NK) cells (p &lt; 0.01). There was no significant difference in numbers of CD4+ T cells, B cells, or neutrophils. When blood samples of 16 patients were examined at various intervals after onset of NE, a significant decrease in the number of NK cells (p &lt; 0.01) was found in the acute phase of the disease. The findings are compatible with the presence of a local host response in the lower respiratory tract to NE virus infection.}},
  author       = {{Linderholm, Mats and Bjermer, Leif and Juto, Per and Roos, Göran and Sandstrom, Thomas and Settergren, Bo and Tarnvik, Arne}},
  issn         = {{1651-1980}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{639--646}},
  publisher    = {{Informa Healthcare}},
  series       = {{Scandinavian Journal of Infectious Diseases}},
  title        = {{Local host response in the lower respiratory tract in nephropathia epidemica}},
  url          = {{http://dx.doi.org/10.3109/00365549309008554}},
  doi          = {{10.3109/00365549309008554}},
  volume       = {{25}},
  year         = {{1993}},
}