IL-4-deficient mice develop less acute but more chronic relapsing collagen-induced arthritis.
(2002) In European Journal of Immunology 32(10). p.2944-2953- Abstract
- Rheumatoid arthritis as well as collagen-induced arthritis (CIA) is thought to involve T cell autoimmunity of the Th1 type and the Th2 cytokine IL-4 has been proposed to play a suppressive role. To exclude a possible skewing role of the mycobacteria used in the complete Freund's adjuvant (CFA) we induced CIA with type II collagen (CII) in incomplete Freund's adjuvant (IFA). Ourresults show that IL-4 deficiency leads to a lesser susceptibility to arthritis and lower B and T cell responses if induced with CII/IFA but not if induced with CII/CFA. In addition, IL-4-deficientmice were less susceptible to arthritis induced with monoclonal anti-CII antibodies. However, mice immunized with CII/IFA later developed a chronic relapsing disease, which... (More)
- Rheumatoid arthritis as well as collagen-induced arthritis (CIA) is thought to involve T cell autoimmunity of the Th1 type and the Th2 cytokine IL-4 has been proposed to play a suppressive role. To exclude a possible skewing role of the mycobacteria used in the complete Freund's adjuvant (CFA) we induced CIA with type II collagen (CII) in incomplete Freund's adjuvant (IFA). Ourresults show that IL-4 deficiency leads to a lesser susceptibility to arthritis and lower B and T cell responses if induced with CII/IFA but not if induced with CII/CFA. In addition, IL-4-deficientmice were less susceptible to arthritis induced with monoclonal anti-CII antibodies. However, mice immunized with CII/IFA later developed a chronic relapsing disease, which was promoted by IL-4 deficiency. We conclude that IL-4 plays different roles depending on the type of adjuvant used and the phase (acute or chronic) of the clinical disease. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/110833
- author
- Svensson, Lars LU ; Nandakumar, Kutty Selva ; Johansson, Åsa LU ; Jansson, Liselotte LU and Holmdahl, Rikard LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Immunology
- volume
- 32
- issue
- 10
- pages
- 2944 - 2953
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:12355448
- wos:000178746600027
- scopus:0036774695
- ISSN
- 1521-4141
- DOI
- 10.1002/1521-4141(2002010)32:10<2944::AID-IMMU2944>3.0.CO;2-4
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Inflammation Research (013212019)
- id
- 7a96fce0-8f51-411a-80c0-a928c51ed62b (old id 110833)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12355448&dopt=Abstract
- date added to LUP
- 2016-04-01 11:36:15
- date last changed
- 2022-01-26 07:31:51
@article{7a96fce0-8f51-411a-80c0-a928c51ed62b,
abstract = {{Rheumatoid arthritis as well as collagen-induced arthritis (CIA) is thought to involve T cell autoimmunity of the Th1 type and the Th2 cytokine IL-4 has been proposed to play a suppressive role. To exclude a possible skewing role of the mycobacteria used in the complete Freund's adjuvant (CFA) we induced CIA with type II collagen (CII) in incomplete Freund's adjuvant (IFA). Ourresults show that IL-4 deficiency leads to a lesser susceptibility to arthritis and lower B and T cell responses if induced with CII/IFA but not if induced with CII/CFA. In addition, IL-4-deficientmice were less susceptible to arthritis induced with monoclonal anti-CII antibodies. However, mice immunized with CII/IFA later developed a chronic relapsing disease, which was promoted by IL-4 deficiency. We conclude that IL-4 plays different roles depending on the type of adjuvant used and the phase (acute or chronic) of the clinical disease.}},
author = {{Svensson, Lars and Nandakumar, Kutty Selva and Johansson, Åsa and Jansson, Liselotte and Holmdahl, Rikard}},
issn = {{1521-4141}},
language = {{eng}},
number = {{10}},
pages = {{2944--2953}},
publisher = {{John Wiley & Sons Inc.}},
series = {{European Journal of Immunology}},
title = {{IL-4-deficient mice develop less acute but more chronic relapsing collagen-induced arthritis.}},
url = {{http://dx.doi.org/10.1002/1521-4141(2002010)32:10<2944::AID-IMMU2944>3.0.CO;2-4}},
doi = {{10.1002/1521-4141(2002010)32:10<2944::AID-IMMU2944>3.0.CO;2-4}},
volume = {{32}},
year = {{2002}},
}