No evidence for genomic imprinting of the human BCR gene
(1994) In Blood 83(12). p.3441-3444- Abstract
- Chronic myeloid leukemias and 5% to 20% of acute lymphoid leukemias are characterized by the Philadelphia chromosome, a reciprocal chromosomal translocation, t(9;22)(q34;q11), generating BCR-ABL and ABL-BCR fusion genes. Cytogenetic studies have recently shown a preferential involvement of the paternally derived chromosome 9 and the maternally derived chromosome 22 in this translocation, indicating that imprinting might be involved in the formation or selection of the translocation. In this study, we have identified a BamHI polymorphism in the coding region of BCR exon 1, allowing us to investigate whether both BCR alleles are transcribed. By using a reverse transcriptase-polymerase chain reaction assay, we show that both BCR alleles are... (More)
- Chronic myeloid leukemias and 5% to 20% of acute lymphoid leukemias are characterized by the Philadelphia chromosome, a reciprocal chromosomal translocation, t(9;22)(q34;q11), generating BCR-ABL and ABL-BCR fusion genes. Cytogenetic studies have recently shown a preferential involvement of the paternally derived chromosome 9 and the maternally derived chromosome 22 in this translocation, indicating that imprinting might be involved in the formation or selection of the translocation. In this study, we have identified a BamHI polymorphism in the coding region of BCR exon 1, allowing us to investigate whether both BCR alleles are transcribed. By using a reverse transcriptase-polymerase chain reaction assay, we show that both BCR alleles are expressed in the peripheral blood cells of normal individuals. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1108692
- author
- Fioretos, Thoas LU ; Heisterkamp, Nora and Groffen, John
- organization
- publishing date
- 1994
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Blood
- volume
- 83
- issue
- 12
- pages
- 3441 - 3444
- publisher
- American Society of Hematology
- external identifiers
-
- pmid:8204871
- scopus:0028319233
- ISSN
- 1528-0020
- language
- English
- LU publication?
- yes
- id
- 8e10e187-47e9-4ad2-bacc-05736ab71e5c (old id 1108692)
- alternative location
- http://bloodjournal.hematologylibrary.org/cgi/reprint/83/12/3441
- date added to LUP
- 2016-04-01 12:01:25
- date last changed
- 2021-01-03 06:26:46
@article{8e10e187-47e9-4ad2-bacc-05736ab71e5c,
abstract = {{Chronic myeloid leukemias and 5% to 20% of acute lymphoid leukemias are characterized by the Philadelphia chromosome, a reciprocal chromosomal translocation, t(9;22)(q34;q11), generating BCR-ABL and ABL-BCR fusion genes. Cytogenetic studies have recently shown a preferential involvement of the paternally derived chromosome 9 and the maternally derived chromosome 22 in this translocation, indicating that imprinting might be involved in the formation or selection of the translocation. In this study, we have identified a BamHI polymorphism in the coding region of BCR exon 1, allowing us to investigate whether both BCR alleles are transcribed. By using a reverse transcriptase-polymerase chain reaction assay, we show that both BCR alleles are expressed in the peripheral blood cells of normal individuals.}},
author = {{Fioretos, Thoas and Heisterkamp, Nora and Groffen, John}},
issn = {{1528-0020}},
language = {{eng}},
number = {{12}},
pages = {{3441--3444}},
publisher = {{American Society of Hematology}},
series = {{Blood}},
title = {{No evidence for genomic imprinting of the human BCR gene}},
url = {{http://bloodjournal.hematologylibrary.org/cgi/reprint/83/12/3441}},
volume = {{83}},
year = {{1994}},
}