Greater diversity of hepatitis C virus genotypes found in Hong Kong than in mainland China
(1995) In Journal of Clinical Microbiology 33(11). p.2931-2934- Abstract
- A hepatitis C virus (HCV) genotyping PCR assay based on type-specific primers was expanded to include genotype 6a as well as genotypes 1a, 1b, 2a, and 3a. The nucleotide sequences of a 194-bp fragment in the center of the HCV core gene showed that the homologies between genotype 6a and genotypes 1a, 1b, 2a, 2b, 3a, and 5 were 81.2, 82.1, 73.8, 77.3, 81.4, and 78.9%, respectively. A high degree of homology (99.6%) was seen in the amplified core region among eight clinically unrelated genotype 6a isolates. Although the Hong Kong Chinese patients had predominantly genotype 1b (70%), it was noteworthy that genotype 6a was the second most common genotype (14%). Four other HCV genotypes--1a, 1b, 2a, and 2b--were also present. In contrast, HCV... (More)
- A hepatitis C virus (HCV) genotyping PCR assay based on type-specific primers was expanded to include genotype 6a as well as genotypes 1a, 1b, 2a, and 3a. The nucleotide sequences of a 194-bp fragment in the center of the HCV core gene showed that the homologies between genotype 6a and genotypes 1a, 1b, 2a, 2b, 3a, and 5 were 81.2, 82.1, 73.8, 77.3, 81.4, and 78.9%, respectively. A high degree of homology (99.6%) was seen in the amplified core region among eight clinically unrelated genotype 6a isolates. Although the Hong Kong Chinese patients had predominantly genotype 1b (70%), it was noteworthy that genotype 6a was the second most common genotype (14%). Four other HCV genotypes--1a, 1b, 2a, and 2b--were also present. In contrast, HCV infection by mainland China was confined to genotypes 1b and 2a. Thus, we found a greater diversity of HCV genotypes in Hong Kong than in mainland China. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1108788
- author
- Zhang, Yong Yuan ; Lok, A S ; Chan, D T and Widell, Anders LU
- organization
- publishing date
- 1995
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Clinical Microbiology
- volume
- 33
- issue
- 11
- pages
- 2931 - 2934
- publisher
- American Society for Microbiology
- external identifiers
-
- pmid:8576348
- scopus:0028834475
- ISSN
- 1098-660X
- language
- English
- LU publication?
- yes
- id
- fa7227a7-a8a4-4579-8808-79470e2c626b (old id 1108788)
- alternative location
- http://jcm.asm.org/cgi/reprint/33/11/2931?view=long&pmid=8576348
- date added to LUP
- 2016-04-01 15:46:39
- date last changed
- 2021-01-03 10:43:44
@article{fa7227a7-a8a4-4579-8808-79470e2c626b,
abstract = {{A hepatitis C virus (HCV) genotyping PCR assay based on type-specific primers was expanded to include genotype 6a as well as genotypes 1a, 1b, 2a, and 3a. The nucleotide sequences of a 194-bp fragment in the center of the HCV core gene showed that the homologies between genotype 6a and genotypes 1a, 1b, 2a, 2b, 3a, and 5 were 81.2, 82.1, 73.8, 77.3, 81.4, and 78.9%, respectively. A high degree of homology (99.6%) was seen in the amplified core region among eight clinically unrelated genotype 6a isolates. Although the Hong Kong Chinese patients had predominantly genotype 1b (70%), it was noteworthy that genotype 6a was the second most common genotype (14%). Four other HCV genotypes--1a, 1b, 2a, and 2b--were also present. In contrast, HCV infection by mainland China was confined to genotypes 1b and 2a. Thus, we found a greater diversity of HCV genotypes in Hong Kong than in mainland China.}},
author = {{Zhang, Yong Yuan and Lok, A S and Chan, D T and Widell, Anders}},
issn = {{1098-660X}},
language = {{eng}},
number = {{11}},
pages = {{2931--2934}},
publisher = {{American Society for Microbiology}},
series = {{Journal of Clinical Microbiology}},
title = {{Greater diversity of hepatitis C virus genotypes found in Hong Kong than in mainland China}},
url = {{http://jcm.asm.org/cgi/reprint/33/11/2931?view=long&pmid=8576348}},
volume = {{33}},
year = {{1995}},
}