Effects of intrapleural mitoxantrone and mepacrine on malignant pleural effusion--a randomised study
(1995) In European Journal of Cancer 31(13-14). p.2203-2208- Abstract
- 30 patients with malignant pleuritis were randomised to be treated, either with intrapleural instillation of mepacrine chloride or with mitoxantrone. The patients were evaluated with chest X-ray and a symptom questionnaire during a follow-up period of 12 weeks. Mitoxantrone levels in the pleural space and plasma were measured at different time points in some of the patients. High concentrations of mitoxantrone were found in the pleural fluid while the plasma concentrations were low, giving a plasma/intracavity ratio generally of less than 1:60. The chest X-rays showed excellent results for both treatment modalities. However, the patients treated with mepacrine chloride experienced greater discomfort with fever and pain, and those treated... (More)
- 30 patients with malignant pleuritis were randomised to be treated, either with intrapleural instillation of mepacrine chloride or with mitoxantrone. The patients were evaluated with chest X-ray and a symptom questionnaire during a follow-up period of 12 weeks. Mitoxantrone levels in the pleural space and plasma were measured at different time points in some of the patients. High concentrations of mitoxantrone were found in the pleural fluid while the plasma concentrations were low, giving a plasma/intracavity ratio generally of less than 1:60. The chest X-rays showed excellent results for both treatment modalities. However, the patients treated with mepacrine chloride experienced greater discomfort with fever and pain, and those treated with mitoxantrone reported significantly less dyspnoea and less asthenia after 4 weeks. We conclude that both treatments are equally effective in preventing the recurrence of malignant effusion. However, mitoxantrone seems to have further advantages when it comes to improving the quality of life. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1108895
- author
- Bjermer, Leif LU ; Gruber, A ; Sue-Chu, M ; Sandström, T ; Eksborg, S and Henriksson, R
- publishing date
- 1995
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- malignant pleuritis, mitoxantrone, mepacrine, pleural effusion
- in
- European Journal of Cancer
- volume
- 31
- issue
- 13-14
- pages
- 2203 - 2208
- publisher
- Elsevier
- external identifiers
-
- pmid:8652243
- scopus:0029593639
- ISSN
- 1879-0852
- DOI
- 10.1016/0959-8049(95)00425-4
- language
- English
- LU publication?
- no
- id
- 2a3edb89-6fb5-406f-87d5-bb309003c418 (old id 1108895)
- date added to LUP
- 2016-04-01 12:14:11
- date last changed
- 2021-07-11 04:56:30
@article{2a3edb89-6fb5-406f-87d5-bb309003c418,
abstract = {{30 patients with malignant pleuritis were randomised to be treated, either with intrapleural instillation of mepacrine chloride or with mitoxantrone. The patients were evaluated with chest X-ray and a symptom questionnaire during a follow-up period of 12 weeks. Mitoxantrone levels in the pleural space and plasma were measured at different time points in some of the patients. High concentrations of mitoxantrone were found in the pleural fluid while the plasma concentrations were low, giving a plasma/intracavity ratio generally of less than 1:60. The chest X-rays showed excellent results for both treatment modalities. However, the patients treated with mepacrine chloride experienced greater discomfort with fever and pain, and those treated with mitoxantrone reported significantly less dyspnoea and less asthenia after 4 weeks. We conclude that both treatments are equally effective in preventing the recurrence of malignant effusion. However, mitoxantrone seems to have further advantages when it comes to improving the quality of life.}},
author = {{Bjermer, Leif and Gruber, A and Sue-Chu, M and Sandström, T and Eksborg, S and Henriksson, R}},
issn = {{1879-0852}},
keywords = {{malignant pleuritis; mitoxantrone; mepacrine; pleural effusion}},
language = {{eng}},
number = {{13-14}},
pages = {{2203--2208}},
publisher = {{Elsevier}},
series = {{European Journal of Cancer}},
title = {{Effects of intrapleural mitoxantrone and mepacrine on malignant pleural effusion--a randomised study}},
url = {{http://dx.doi.org/10.1016/0959-8049(95)00425-4}},
doi = {{10.1016/0959-8049(95)00425-4}},
volume = {{31}},
year = {{1995}},
}