Urinary cotinine in children and adults during and after semiexperimental exposure to environmental tobacco smoke
(1995) In Archives of Environmental Health 50(2). p.130-138- Abstract
- Urinary cotinine (U-cotinine) as a biomarker of environmental tobacco smoke exposure was evaluated in 14 children (age 4-11 y) and in 7 adults who were exposed to environmental tobacco smoke at an air nicotine level of 110 mg/m3 for 2 h in a bus. Nicotine in air and U-cotinine were measured by gas chromatography/mass spectrometry before, during, and after the experiment. U-cotinine rose rapidly to a maximum after a median of 6 h following the end of exposure; remained at an apparent plateau for half a day; and then decreased exponentially, with a mean half-time of 19 h (95% confidence interval 18-20 h; no significant difference between children and adults). The maximum U-cotinine was higher in the children (mean = 22 mg/l) than in the... (More)
- Urinary cotinine (U-cotinine) as a biomarker of environmental tobacco smoke exposure was evaluated in 14 children (age 4-11 y) and in 7 adults who were exposed to environmental tobacco smoke at an air nicotine level of 110 mg/m3 for 2 h in a bus. Nicotine in air and U-cotinine were measured by gas chromatography/mass spectrometry before, during, and after the experiment. U-cotinine rose rapidly to a maximum after a median of 6 h following the end of exposure; remained at an apparent plateau for half a day; and then decreased exponentially, with a mean half-time of 19 h (95% confidence interval 18-20 h; no significant difference between children and adults). The maximum U-cotinine was higher in the children (mean = 22 mg/l) than in the adults (13 mg/l; p = .005); decreased with age among the children (r = -.74; p = .002); and increased as the estimated inhaled nicotine dose increased. Therefore, the findings of the present study showed that young children had higher U-cotinine than adults at the same experimental environmental tobacco smoke exposure, probably because they had a higher relative nicotine dose because of a higher relative ventilation rate, and possibly also because of metabolic differences; the elimination rate did not differ. The long half-time makes U-cotinine a good biomarker of environmental tobacco smoke exposure; the time of sampling is not very critical. Dilution-adjusted concentrations should be employed, and in children, preferably by density correction. A certain urinary cotinine level indicates a lower environmental tobacco smoke exposure in a small child than in an adult. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1109633
- author
- Willers, Stefan LU ; Skarping, Gunnar LU ; Dalene, Marianne LU and Skerfving, Staffan LU
- organization
- publishing date
- 1995
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Archives of Environmental Health
- volume
- 50
- issue
- 2
- pages
- 130 - 138
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:7786049
- scopus:0029060716
- ISSN
- 0003-9896
- language
- English
- LU publication?
- yes
- id
- 20bf3da9-0d4e-4c00-aec7-25dee5b88326 (old id 1109633)
- alternative location
- http://elin.lub.lu.se/cgi-bin/linker/ebsco_local?9507100263
- date added to LUP
- 2016-04-01 16:00:40
- date last changed
- 2021-02-28 06:45:14
@article{20bf3da9-0d4e-4c00-aec7-25dee5b88326,
abstract = {{Urinary cotinine (U-cotinine) as a biomarker of environmental tobacco smoke exposure was evaluated in 14 children (age 4-11 y) and in 7 adults who were exposed to environmental tobacco smoke at an air nicotine level of 110 mg/m3 for 2 h in a bus. Nicotine in air and U-cotinine were measured by gas chromatography/mass spectrometry before, during, and after the experiment. U-cotinine rose rapidly to a maximum after a median of 6 h following the end of exposure; remained at an apparent plateau for half a day; and then decreased exponentially, with a mean half-time of 19 h (95% confidence interval 18-20 h; no significant difference between children and adults). The maximum U-cotinine was higher in the children (mean = 22 mg/l) than in the adults (13 mg/l; p = .005); decreased with age among the children (r = -.74; p = .002); and increased as the estimated inhaled nicotine dose increased. Therefore, the findings of the present study showed that young children had higher U-cotinine than adults at the same experimental environmental tobacco smoke exposure, probably because they had a higher relative nicotine dose because of a higher relative ventilation rate, and possibly also because of metabolic differences; the elimination rate did not differ. The long half-time makes U-cotinine a good biomarker of environmental tobacco smoke exposure; the time of sampling is not very critical. Dilution-adjusted concentrations should be employed, and in children, preferably by density correction. A certain urinary cotinine level indicates a lower environmental tobacco smoke exposure in a small child than in an adult.}},
author = {{Willers, Stefan and Skarping, Gunnar and Dalene, Marianne and Skerfving, Staffan}},
issn = {{0003-9896}},
language = {{eng}},
number = {{2}},
pages = {{130--138}},
publisher = {{Taylor & Francis}},
series = {{Archives of Environmental Health}},
title = {{Urinary cotinine in children and adults during and after semiexperimental exposure to environmental tobacco smoke}},
url = {{http://elin.lub.lu.se/cgi-bin/linker/ebsco_local?9507100263}},
volume = {{50}},
year = {{1995}},
}