Clinical characteristics and biological parameters in temperamental clusters of suicide attempters
(1997) In Journal of Affective Disorders 44(1). p.45-55- Abstract
- A sample of 215 suicide attempters was categorized in a cluster analysis into four groups according to temperamental trails. Monoamine metabolites in the cerebrospinal fluid were analysed (n = 106). Dexamethasone suppression tests (DST) were performed (n = 154) and the activity of the enzyme monoamine oxidase in platelets (pl-MAO) was assessed (n = 103). Patients belonging to the two clusters with the most deviant temperament profiles (nos 2 and 3) were young and scored high on the Beck Hopelessness Scale and the Suicide Assessment Scale. "Cluster 3" ("neurotic, impulsive, aggressive") patients often had dysthymia and axis II, cluster B diagnoses (e.g. borderline or histrionic personality). "Cluster 2" ("neurotic and introverted") patients... (More)
- A sample of 215 suicide attempters was categorized in a cluster analysis into four groups according to temperamental trails. Monoamine metabolites in the cerebrospinal fluid were analysed (n = 106). Dexamethasone suppression tests (DST) were performed (n = 154) and the activity of the enzyme monoamine oxidase in platelets (pl-MAO) was assessed (n = 103). Patients belonging to the two clusters with the most deviant temperament profiles (nos 2 and 3) were young and scored high on the Beck Hopelessness Scale and the Suicide Assessment Scale. "Cluster 3" ("neurotic, impulsive, aggressive") patients often had dysthymia and axis II, cluster B diagnoses (e.g. borderline or histrionic personality). "Cluster 2" ("neurotic and introverted") patients often had major depression. The "Cluster 1", with on the whole a normal temperament profile, had significantly higher levels of post-DST cortisol than the other clusters. The "Cluster 4" had a normal temperament profile. Adjustment disorders were most common in "Cluster 1" and "Cluster 4". The monoamine metabolite levels did not differ between the clusters, and the differences in pl-MAO activity disappeared after adjusting for age and gender. The results suggest that temperament profiles in suicide attempters are related to psychiatric diagnoses, suicidality, hopelessness, and post-DST cortisol, but are not predictive of completed suicide. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1111727
- author
- Engström, Gunnar LU ; Alling, Christer LU ; Gustavsson, P ; Oreland, L and Träskman Bendz, Lil LU
- organization
- publishing date
- 1997
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Temperament, Suicide attempts, Depression, Monoamine metabolites, Monoamine oxidase, Dexamethasone
- in
- Journal of Affective Disorders
- volume
- 44
- issue
- 1
- pages
- 45 - 55
- publisher
- Elsevier
- external identifiers
-
- pmid:9186802
- scopus:0031004192
- ISSN
- 1573-2517
- DOI
- 10.1016/S0165-0327(97)00029-3
- language
- English
- LU publication?
- yes
- id
- 06eb2fa9-5f66-4090-9a59-7b2bbdcad500 (old id 1111727)
- date added to LUP
- 2016-04-01 12:05:23
- date last changed
- 2022-01-26 22:40:44
@article{06eb2fa9-5f66-4090-9a59-7b2bbdcad500,
abstract = {{A sample of 215 suicide attempters was categorized in a cluster analysis into four groups according to temperamental trails. Monoamine metabolites in the cerebrospinal fluid were analysed (n = 106). Dexamethasone suppression tests (DST) were performed (n = 154) and the activity of the enzyme monoamine oxidase in platelets (pl-MAO) was assessed (n = 103). Patients belonging to the two clusters with the most deviant temperament profiles (nos 2 and 3) were young and scored high on the Beck Hopelessness Scale and the Suicide Assessment Scale. "Cluster 3" ("neurotic, impulsive, aggressive") patients often had dysthymia and axis II, cluster B diagnoses (e.g. borderline or histrionic personality). "Cluster 2" ("neurotic and introverted") patients often had major depression. The "Cluster 1", with on the whole a normal temperament profile, had significantly higher levels of post-DST cortisol than the other clusters. The "Cluster 4" had a normal temperament profile. Adjustment disorders were most common in "Cluster 1" and "Cluster 4". The monoamine metabolite levels did not differ between the clusters, and the differences in pl-MAO activity disappeared after adjusting for age and gender. The results suggest that temperament profiles in suicide attempters are related to psychiatric diagnoses, suicidality, hopelessness, and post-DST cortisol, but are not predictive of completed suicide.}},
author = {{Engström, Gunnar and Alling, Christer and Gustavsson, P and Oreland, L and Träskman Bendz, Lil}},
issn = {{1573-2517}},
keywords = {{Temperament; Suicide attempts; Depression; Monoamine metabolites; Monoamine oxidase; Dexamethasone}},
language = {{eng}},
number = {{1}},
pages = {{45--55}},
publisher = {{Elsevier}},
series = {{Journal of Affective Disorders}},
title = {{Clinical characteristics and biological parameters in temperamental clusters of suicide attempters}},
url = {{http://dx.doi.org/10.1016/S0165-0327(97)00029-3}},
doi = {{10.1016/S0165-0327(97)00029-3}},
volume = {{44}},
year = {{1997}},
}