Substance P relaxes rat bronchial smooth muscle via epithelial prostanoid synthesis
(1999) In Respiration 66(4). p.355-359- Abstract
- BACKGROUND: Substance P is present in bronchial nerve fibres. The physiological actions of substance P are mediated via tachykinin NK(1) receptors. Immunochemical studies have demonstrated tachykinin NK(1) receptors in the rat airway epithelium. OBJECTIVE: To elucidate how epithelial tachykinin NK(1) receptors affect smooth muscle response to substance P. METHODS: Contractile response of isolated rat bronchial trunk with or without epithelium was recorded. RESULTS: In intact segments precontracted by 5-hydroxytryptamine, relaxation was induced by substance P and the nitric oxide donor, sodium nitroprusside. Removal of the epithelium abolished relaxation induced by substance P but did not affect relaxation induced by sodium nitroprusside.... (More)
- BACKGROUND: Substance P is present in bronchial nerve fibres. The physiological actions of substance P are mediated via tachykinin NK(1) receptors. Immunochemical studies have demonstrated tachykinin NK(1) receptors in the rat airway epithelium. OBJECTIVE: To elucidate how epithelial tachykinin NK(1) receptors affect smooth muscle response to substance P. METHODS: Contractile response of isolated rat bronchial trunk with or without epithelium was recorded. RESULTS: In intact segments precontracted by 5-hydroxytryptamine, relaxation was induced by substance P and the nitric oxide donor, sodium nitroprusside. Removal of the epithelium abolished relaxation induced by substance P but did not affect relaxation induced by sodium nitroprusside. The cyclo-oxygenase inhibitor, indomethacin, but not the nitric oxide synthase inhibitor, L-N(G)-monomethylarginine, reduced the relaxation in response to substance P. CONCLUSIONS: Epithelial tachykinin NK(1) receptors mediate substance-P-induced relaxation of rat bronchial smooth muscle via release of prostanoids but not nitric oxide. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1114544
- author
- Bodelsson, Mikael LU ; Blomquist, Sten LU ; Caverius, Kaj and Tornebrandt, Kenneth
- organization
- publishing date
- 1999
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Bronchi, Epithelium, Indomethacin, Nitric oxide, Serotonin, Substance P
- in
- Respiration
- volume
- 66
- issue
- 4
- pages
- 355 - 359
- publisher
- Karger
- external identifiers
-
- pmid:10461085
- scopus:0032780769
- ISSN
- 1423-0356
- DOI
- 10.1159/000029407
- language
- English
- LU publication?
- yes
- id
- cc6dee7d-85ee-4ba7-957a-b9291726270e (old id 1114544)
- date added to LUP
- 2016-04-01 16:50:38
- date last changed
- 2022-01-28 22:33:59
@article{cc6dee7d-85ee-4ba7-957a-b9291726270e, abstract = {{BACKGROUND: Substance P is present in bronchial nerve fibres. The physiological actions of substance P are mediated via tachykinin NK(1) receptors. Immunochemical studies have demonstrated tachykinin NK(1) receptors in the rat airway epithelium. OBJECTIVE: To elucidate how epithelial tachykinin NK(1) receptors affect smooth muscle response to substance P. METHODS: Contractile response of isolated rat bronchial trunk with or without epithelium was recorded. RESULTS: In intact segments precontracted by 5-hydroxytryptamine, relaxation was induced by substance P and the nitric oxide donor, sodium nitroprusside. Removal of the epithelium abolished relaxation induced by substance P but did not affect relaxation induced by sodium nitroprusside. The cyclo-oxygenase inhibitor, indomethacin, but not the nitric oxide synthase inhibitor, L-N(G)-monomethylarginine, reduced the relaxation in response to substance P. CONCLUSIONS: Epithelial tachykinin NK(1) receptors mediate substance-P-induced relaxation of rat bronchial smooth muscle via release of prostanoids but not nitric oxide.}}, author = {{Bodelsson, Mikael and Blomquist, Sten and Caverius, Kaj and Tornebrandt, Kenneth}}, issn = {{1423-0356}}, keywords = {{Bronchi; Epithelium; Indomethacin; Nitric oxide; Serotonin; Substance P}}, language = {{eng}}, number = {{4}}, pages = {{355--359}}, publisher = {{Karger}}, series = {{Respiration}}, title = {{Substance P relaxes rat bronchial smooth muscle via epithelial prostanoid synthesis}}, url = {{http://dx.doi.org/10.1159/000029407}}, doi = {{10.1159/000029407}}, volume = {{66}}, year = {{1999}}, }