Förmaksflimmer--epidemiologiska och elektrofysiologiska aspekter
(1999) In Tidsskrift for Den Norske Lægeforening 119(11). p.1601-1604- Abstract
- Atrial fibrillation is a common and therapy-requiring cardiac arrhythmia. The chronic form becomes identified in population studies from the age of 50 and increases with age. The number of Norwegian individuals with this arrhythmia is estimated to be slightly in excess of 40,000 and it will increase approximately by another 5,000 until the year 2010. Mechanisms responsible for initiation and maintenance of the arrhythmia are increasingly better understood. The paroxysmal form often has a focal origin, allowing curative treatment, but can also be associated with signs of deficient interatrial conduction. The chronic form is perpetuated partly by a shortening of atrial myocardial refractoriness, attributed to a failure in the intracellular... (More)
- Atrial fibrillation is a common and therapy-requiring cardiac arrhythmia. The chronic form becomes identified in population studies from the age of 50 and increases with age. The number of Norwegian individuals with this arrhythmia is estimated to be slightly in excess of 40,000 and it will increase approximately by another 5,000 until the year 2010. Mechanisms responsible for initiation and maintenance of the arrhythmia are increasingly better understood. The paroxysmal form often has a focal origin, allowing curative treatment, but can also be associated with signs of deficient interatrial conduction. The chronic form is perpetuated partly by a shortening of atrial myocardial refractoriness, attributed to a failure in the intracellular turnover of Ca-ions due to the high excitation rate. Ongoing studies are expected to illustrate the clinical benefit of Ca-blockers prior to cardioversion of chronic atrial fibrillation. The further relapse rate is low in patients who have maintained sinus rhythm more than 1-2 months following conversion. It is therefore possible that, following a successful conversion to sinus rhythm, aggressive antiarrhythmic treatment should be given during a limited period only--a strategy which has to be evaluated in prospective studies. (Less)
- Abstract (Swedish)
- Förmaksflimmer är en vanlig och behandlingskrävande hjärtrytmrubbning. Det kroniska förmaksflimret finner man i befolkningen från 50-årsåldern i alltmer ökande omfattning. Antalet individer i Norge med denna rytmrubbning beräknas vara drygt 40000 och ökar med ytterligare cirka 5000 till år 2010. Mekanismerna bakom initiering och underhåll av förmaksflimmer kartläggs allt bättre. Den paroxysmala formen har i många fall ett fokalt ursprung, tillåtande kurativ terapi men kan också knytas till interatriala impulsledningsdefekter. Den kroniska formen fortgår bl.a. på grund av s.k. remodellering - en förkortad muskelrefraktäritet, orsakad av att den höga flimmerfrekvensen leder till en defekt intracellulär omsättning av Ca-joner. Pågående... (More)
- Förmaksflimmer är en vanlig och behandlingskrävande hjärtrytmrubbning. Det kroniska förmaksflimret finner man i befolkningen från 50-årsåldern i alltmer ökande omfattning. Antalet individer i Norge med denna rytmrubbning beräknas vara drygt 40000 och ökar med ytterligare cirka 5000 till år 2010. Mekanismerna bakom initiering och underhåll av förmaksflimmer kartläggs allt bättre. Den paroxysmala formen har i många fall ett fokalt ursprung, tillåtande kurativ terapi men kan också knytas till interatriala impulsledningsdefekter. Den kroniska formen fortgår bl.a. på grund av s.k. remodellering - en förkortad muskelrefraktäritet, orsakad av att den höga flimmerfrekvensen leder till en defekt intracellulär omsättning av Ca-joner. Pågående studier förväntas bekräfta den kliniska nyttan av förbehandling med Ca-blockerare inför elregularisering av kroniskt förmaksflimmer. Den fortsatta återfallsfrekvensen är låg hos de patienter som kunnat bibehålla sinusrytm 1-2 månader efter regularisering. Detta innebär att antiarytmisk behandling möjligen endast behöver ges under begränsad tid efter regularisering, en fråga som måste belysas i vetenskapliga studier. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1116106
- author
- Olsson, Bertil LU
- organization
- alternative title
- Atrial fibrillation--epidemiological and electrophysiological aspects
- publishing date
- 1999
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Arytmier, Epidemiologi, Hjerte, Behandling
- in
- Tidsskrift for Den Norske Lægeforening
- volume
- 119
- issue
- 11
- pages
- 1601 - 1604
- publisher
- Norsk laegeforening
- external identifiers
-
- pmid:10385803
- scopus:0033616928
- ISSN
- 0029-2001
- language
- Swedish
- LU publication?
- yes
- id
- d15d3fc2-15fe-4c91-8808-1fc2027fc8b6 (old id 1116106)
- alternative location
- http://ww2.tidsskriftet.no/tsweb/199911/art6.html
- date added to LUP
- 2016-04-01 16:44:48
- date last changed
- 2022-03-15 02:39:02
@article{d15d3fc2-15fe-4c91-8808-1fc2027fc8b6,
abstract = {{Atrial fibrillation is a common and therapy-requiring cardiac arrhythmia. The chronic form becomes identified in population studies from the age of 50 and increases with age. The number of Norwegian individuals with this arrhythmia is estimated to be slightly in excess of 40,000 and it will increase approximately by another 5,000 until the year 2010. Mechanisms responsible for initiation and maintenance of the arrhythmia are increasingly better understood. The paroxysmal form often has a focal origin, allowing curative treatment, but can also be associated with signs of deficient interatrial conduction. The chronic form is perpetuated partly by a shortening of atrial myocardial refractoriness, attributed to a failure in the intracellular turnover of Ca-ions due to the high excitation rate. Ongoing studies are expected to illustrate the clinical benefit of Ca-blockers prior to cardioversion of chronic atrial fibrillation. The further relapse rate is low in patients who have maintained sinus rhythm more than 1-2 months following conversion. It is therefore possible that, following a successful conversion to sinus rhythm, aggressive antiarrhythmic treatment should be given during a limited period only--a strategy which has to be evaluated in prospective studies.}},
author = {{Olsson, Bertil}},
issn = {{0029-2001}},
keywords = {{Arytmier; Epidemiologi; Hjerte; Behandling}},
language = {{swe}},
number = {{11}},
pages = {{1601--1604}},
publisher = {{Norsk laegeforening}},
series = {{Tidsskrift for Den Norske Lægeforening}},
title = {{Förmaksflimmer--epidemiologiska och elektrofysiologiska aspekter}},
url = {{http://ww2.tidsskriftet.no/tsweb/199911/art6.html}},
volume = {{119}},
year = {{1999}},
}