T-lymphocyte-epithelial-cell interactions: integrin alpha(E)(CD103)beta(7), LEEP-CAM and chemokines
(2000) In Current Opinion in Cell Biology 12(5). p.563-568- Abstract
- The epithelia are the avascular layers of cells that cover the environment-exposed surfaces of the body. It appears that T cells localize to selected sites in or adjacent to epithelia via the selective expression of adhesion molecules and chemokine receptors on T cells. These bind to counter-receptors and to chemokines expressed by epithelial cells. Recently, there has been an advance in our understanding of the interaction of the alpha(Ebeta7) integrin with its epithelial cell ligand, E-cadherin. In addition, a new adhesion molecule has been identified on non-intestinal epithelial cells, termed lymphocyte-endothelial-epithelial-cell adhesion molecule (LEEP-CAM). Finally, there have been advances in our understanding of the role of skin-... (More)
- The epithelia are the avascular layers of cells that cover the environment-exposed surfaces of the body. It appears that T cells localize to selected sites in or adjacent to epithelia via the selective expression of adhesion molecules and chemokine receptors on T cells. These bind to counter-receptors and to chemokines expressed by epithelial cells. Recently, there has been an advance in our understanding of the interaction of the alpha(Ebeta7) integrin with its epithelial cell ligand, E-cadherin. In addition, a new adhesion molecule has been identified on non-intestinal epithelial cells, termed lymphocyte-endothelial-epithelial-cell adhesion molecule (LEEP-CAM). Finally, there have been advances in our understanding of the role of skin- or gut-epithelia-derived chemokines in regulating activated T cell homing to these sites. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1116326
- author
- Agace, William LU ; Higgins, J M ; Sadasivan, B ; Brenner, M B and Parker, C M
- organization
- publishing date
- 2000
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- T cell, CD103, Lymphocyte, Chemokine, Homing, Epithelium, Cell adhesion, Cell adhesion molecule, Chemokine receptor, Alpha E
- in
- Current Opinion in Cell Biology
- volume
- 12
- issue
- 5
- pages
- 563 - 568
- publisher
- Elsevier
- external identifiers
-
- pmid:10978890
- scopus:0033822237
- ISSN
- 0955-0674
- DOI
- 10.1016/S0955-0674(00)00132-0
- language
- English
- LU publication?
- yes
- id
- f60f8fd2-fdd6-404b-9618-a811ef4f7cf3 (old id 1116326)
- date added to LUP
- 2016-04-01 16:51:30
- date last changed
- 2022-01-28 22:39:27
@article{f60f8fd2-fdd6-404b-9618-a811ef4f7cf3, abstract = {{The epithelia are the avascular layers of cells that cover the environment-exposed surfaces of the body. It appears that T cells localize to selected sites in or adjacent to epithelia via the selective expression of adhesion molecules and chemokine receptors on T cells. These bind to counter-receptors and to chemokines expressed by epithelial cells. Recently, there has been an advance in our understanding of the interaction of the alpha(Ebeta7) integrin with its epithelial cell ligand, E-cadherin. In addition, a new adhesion molecule has been identified on non-intestinal epithelial cells, termed lymphocyte-endothelial-epithelial-cell adhesion molecule (LEEP-CAM). Finally, there have been advances in our understanding of the role of skin- or gut-epithelia-derived chemokines in regulating activated T cell homing to these sites.}}, author = {{Agace, William and Higgins, J M and Sadasivan, B and Brenner, M B and Parker, C M}}, issn = {{0955-0674}}, keywords = {{T cell; CD103; Lymphocyte; Chemokine; Homing; Epithelium; Cell adhesion; Cell adhesion molecule; Chemokine receptor; Alpha E}}, language = {{eng}}, number = {{5}}, pages = {{563--568}}, publisher = {{Elsevier}}, series = {{Current Opinion in Cell Biology}}, title = {{T-lymphocyte-epithelial-cell interactions: integrin alpha(E)(CD103)beta(7), LEEP-CAM and chemokines}}, url = {{http://dx.doi.org/10.1016/S0955-0674(00)00132-0}}, doi = {{10.1016/S0955-0674(00)00132-0}}, volume = {{12}}, year = {{2000}}, }