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Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

Horikawa, Y ; Oda, N ; Cox, N J ; Li, X ; Orho-Melander, Marju LU ; Hara, M ; Hinokio, Y ; Lindner, T H ; Mashima, H and Schwarz, P E , et al. (2000) In Nature Genetics 26(2). p.163-175
Abstract
Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes worldwide, affecting approximately 4% of the world's adult population. It is multifactorial in origin with both genetic and environmental factors contributing to its development. A genome-wide screen for type 2 diabetes genes carried out in Mexican Americans localized a susceptibility gene, designated NIDDM1, to chromosome 2. Here we describe the positional cloning of a gene located in the NIDDM1 region that shows association with type 2 diabetes in Mexican Americans and a Northern European population from the Botnia region of Finland. This putative diabetes-susceptibility gene encodes a ubiquitously expressed member of the calpain-like cysteine... (More)
Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes worldwide, affecting approximately 4% of the world's adult population. It is multifactorial in origin with both genetic and environmental factors contributing to its development. A genome-wide screen for type 2 diabetes genes carried out in Mexican Americans localized a susceptibility gene, designated NIDDM1, to chromosome 2. Here we describe the positional cloning of a gene located in the NIDDM1 region that shows association with type 2 diabetes in Mexican Americans and a Northern European population from the Botnia region of Finland. This putative diabetes-susceptibility gene encodes a ubiquitously expressed member of the calpain-like cysteine protease family, calpain-10 (CAPN10). This finding suggests a novel pathway that may contribute to the development of type 2 diabetes. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Genetics
volume
26
issue
2
pages
163 - 175
publisher
Nature Publishing Group
external identifiers
  • pmid:11017071
  • scopus:0033772073
  • pmid:11017071
ISSN
1546-1718
DOI
10.1038/79876
language
English
LU publication?
yes
id
ad4d5ab3-7a8c-41d2-86b9-c740b0fa2a81 (old id 1118025)
date added to LUP
2016-04-01 16:44:12
date last changed
2024-04-12 05:59:36
@article{ad4d5ab3-7a8c-41d2-86b9-c740b0fa2a81,
  abstract     = {{Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes worldwide, affecting approximately 4% of the world's adult population. It is multifactorial in origin with both genetic and environmental factors contributing to its development. A genome-wide screen for type 2 diabetes genes carried out in Mexican Americans localized a susceptibility gene, designated NIDDM1, to chromosome 2. Here we describe the positional cloning of a gene located in the NIDDM1 region that shows association with type 2 diabetes in Mexican Americans and a Northern European population from the Botnia region of Finland. This putative diabetes-susceptibility gene encodes a ubiquitously expressed member of the calpain-like cysteine protease family, calpain-10 (CAPN10). This finding suggests a novel pathway that may contribute to the development of type 2 diabetes.}},
  author       = {{Horikawa, Y and Oda, N and Cox, N J and Li, X and Orho-Melander, Marju and Hara, M and Hinokio, Y and Lindner, T H and Mashima, H and Schwarz, P E and del Bosque-Plata, L and Horikawa, Y and Oda, Y and Yoshiuchi, I and Colilla, S and Polonsky, K S and Wei, S and Concannon, P and Iwasaki, N and Schulze, J and Baier, Leslie J. and Bogardus, Clifton and Groop, Leif and Boerwinkle, Eric and Hanis, Craig L. and Bell, Graeme I.}},
  issn         = {{1546-1718}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{163--175}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Genetics}},
  title        = {{Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus}},
  url          = {{http://dx.doi.org/10.1038/79876}},
  doi          = {{10.1038/79876}},
  volume       = {{26}},
  year         = {{2000}},
}