Long-term outcome of acute hepatitis B and C in an outbreak of hepatitis in 1969-72
(2000) In European Journal of Clinical Microbiology & Infectious Diseases 19(1). p.21-26- Abstract
- The objective of this study was to investigate the epidemiology, etiology, and long-term outcome of an extended outbreak of acute hepatitis that occurred in an area of Sweden between 1969 and 1972. The outbreak was analyzed retrospectively by retesting stored frozen serum samples for the presence of hepatitis A, B and C markers. The results were compared with the diagnoses that had been determined during the outbreak. Of 180 patients, 29 (16%) had acute hepatitis A, 126 (70%) had acute hepatitis B, and eight (4.4%) had acute hepatitis C. The Australia antigen test used during the outbreak had failed to identify 21 patients with acute hepatitis B virus infection. Genotyping of the hepatitis B virus strains showed that genotype D was the... (More)
- The objective of this study was to investigate the epidemiology, etiology, and long-term outcome of an extended outbreak of acute hepatitis that occurred in an area of Sweden between 1969 and 1972. The outbreak was analyzed retrospectively by retesting stored frozen serum samples for the presence of hepatitis A, B and C markers. The results were compared with the diagnoses that had been determined during the outbreak. Of 180 patients, 29 (16%) had acute hepatitis A, 126 (70%) had acute hepatitis B, and eight (4.4%) had acute hepatitis C. The Australia antigen test used during the outbreak had failed to identify 21 patients with acute hepatitis B virus infection. Genotyping of the hepatitis B virus strains showed that genotype D was the most prevalent, irrespective of the transmission route. An attempt was made to follow up patients with unresolved hepatitis B virus infection, 25-27 years after the acute infection. None of the 100 patients with acute hepatitis B infection who were traced had become chronic carriers. In ten patients with hepatitis C virus infection, the follow-up showed considerable variation in the outcome, ranging from spontaneous resolution to death through liver cirrhosis. Intravenous drug users had a high prevalence of hepatitis C virus infection, with 52% testing positive for hepatitis C antibodies. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1118142
- author
- Bläckberg, Jonas LU ; Braconier, Jean Henrik LU ; Widell, Anders LU and Kidd-Ljunggren, Karin LU
- organization
- publishing date
- 2000
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Clinical Microbiology & Infectious Diseases
- volume
- 19
- issue
- 1
- pages
- 21 - 26
- publisher
- Springer
- external identifiers
-
- pmid:10706175
- scopus:0033950305
- ISSN
- 1435-4373
- DOI
- 10.1007/s100960050004
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Infection Medicine (SUS) (013008000), Clinical Microbiology, Malmö (013011000)
- id
- 2ac6cb6f-51ad-430f-808a-d9800c3c6a0c (old id 1118142)
- date added to LUP
- 2016-04-01 16:57:49
- date last changed
- 2022-01-28 23:22:55
@article{2ac6cb6f-51ad-430f-808a-d9800c3c6a0c, abstract = {{The objective of this study was to investigate the epidemiology, etiology, and long-term outcome of an extended outbreak of acute hepatitis that occurred in an area of Sweden between 1969 and 1972. The outbreak was analyzed retrospectively by retesting stored frozen serum samples for the presence of hepatitis A, B and C markers. The results were compared with the diagnoses that had been determined during the outbreak. Of 180 patients, 29 (16%) had acute hepatitis A, 126 (70%) had acute hepatitis B, and eight (4.4%) had acute hepatitis C. The Australia antigen test used during the outbreak had failed to identify 21 patients with acute hepatitis B virus infection. Genotyping of the hepatitis B virus strains showed that genotype D was the most prevalent, irrespective of the transmission route. An attempt was made to follow up patients with unresolved hepatitis B virus infection, 25-27 years after the acute infection. None of the 100 patients with acute hepatitis B infection who were traced had become chronic carriers. In ten patients with hepatitis C virus infection, the follow-up showed considerable variation in the outcome, ranging from spontaneous resolution to death through liver cirrhosis. Intravenous drug users had a high prevalence of hepatitis C virus infection, with 52% testing positive for hepatitis C antibodies.}}, author = {{Bläckberg, Jonas and Braconier, Jean Henrik and Widell, Anders and Kidd-Ljunggren, Karin}}, issn = {{1435-4373}}, language = {{eng}}, number = {{1}}, pages = {{21--26}}, publisher = {{Springer}}, series = {{European Journal of Clinical Microbiology & Infectious Diseases}}, title = {{Long-term outcome of acute hepatitis B and C in an outbreak of hepatitis in 1969-72}}, url = {{http://dx.doi.org/10.1007/s100960050004}}, doi = {{10.1007/s100960050004}}, volume = {{19}}, year = {{2000}}, }