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Isodicentric 7p, idic(7)(q11.2), in acute myeloid

Johansson, Bertil LU ; Axelsson, Per ; Billström, Rolf ; Strömbeck, Bodil LU ; Arheden, Kristina ; Olofsson, Tor ; Cervin, Anneli ; Adriansson, Magnus ; Tanke, Hans J. and Mitelman, Felix LU orcid , et al. (2001) In Genes, Chromosomes and Cancer 30(3). p.261-266
Abstract
Three adult de novo acute myeloid leukemias (AML M1, M2, and M4) with an isochromosome 7p are presented. No additional abnormalities were deterred by G-band and multicolor, using combined binary ratio labeling, fluorescence in situ hybridization (FISH) analyses, indicating that the i(7p) was the sole. i.e., the primary, chromosomal aberration. Although the patients were elderly-68, 72, and 78 years old-they all responded very well to chemotherapy, achieving complete remission lasting more than a year. Further FISH analyses, using painting, centromeric, as well as 7q11.2-specific YAC probes, revealed that the i(7p) contained two centromeres and that the breakpoints were located in 7q11.2. Thus, the abnormality should formally be designated... (More)
Three adult de novo acute myeloid leukemias (AML M1, M2, and M4) with an isochromosome 7p are presented. No additional abnormalities were deterred by G-band and multicolor, using combined binary ratio labeling, fluorescence in situ hybridization (FISH) analyses, indicating that the i(7p) was the sole. i.e., the primary, chromosomal aberration. Although the patients were elderly-68, 72, and 78 years old-they all responded very well to chemotherapy, achieving complete remission lasting more than a year. Further FISH analyses, using painting, centromeric, as well as 7q11.2-specific YAC probes, revealed that the i(7p) contained two centromeres and that the breakpoints were located in 7q11.2. Thus, the abnormality should formally be designated idic(7)(q11.2). The detailed mapping disclosed a breakpoint heterogeneity, with the breaks in 7q11.2 varying among the cases, being at least 1,310 kb apart. Furthermore, the breakpoints also differed within one of the cases, being located on both the proximal and the distal side of the most centromeric probe used. Based on our three patients, as well as on a previously reported 82-year-old patient with AML M2 and idic(7)(q11) as the only chromosomal change, we suggest that this abnormality, as the sole anomaly, is associated with AML in elderly patients who display a good response to induction chemotherapy and. hence, have a favorable prognosis. Furthermore, the heterogeneous breakpoints in 7q11.2 suggest that the important functional outcome of the idic(7)(q11.2) is the genomic imbalance incurred, i.e., gain of 7p and loss of 7q material, rather than a rearrangement of a specific gene. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Genes, Chromosomes and Cancer
volume
30
issue
3
pages
261 - 266
publisher
Wiley-Liss Inc.
external identifiers
  • wos:000166849300006
  • scopus:0035147020
ISSN
1045-2257
DOI
10.1002/1098-2264(2000)9999:9999<::AID-GCC1087>3.0.CO;2-A
language
English
LU publication?
yes
id
e99e0922-bc5b-4bdd-8a0f-f9981f3cbaa1 (old id 1120206)
date added to LUP
2016-04-01 12:03:32
date last changed
2025-04-04 14:28:45
@article{e99e0922-bc5b-4bdd-8a0f-f9981f3cbaa1,
  abstract     = {{Three adult de novo acute myeloid leukemias (AML M1, M2, and M4) with an isochromosome 7p are presented. No additional abnormalities were deterred by G-band and multicolor, using combined binary ratio labeling, fluorescence in situ hybridization (FISH) analyses, indicating that the i(7p) was the sole. i.e., the primary, chromosomal aberration. Although the patients were elderly-68, 72, and 78 years old-they all responded very well to chemotherapy, achieving complete remission lasting more than a year. Further FISH analyses, using painting, centromeric, as well as 7q11.2-specific YAC probes, revealed that the i(7p) contained two centromeres and that the breakpoints were located in 7q11.2. Thus, the abnormality should formally be designated idic(7)(q11.2). The detailed mapping disclosed a breakpoint heterogeneity, with the breaks in 7q11.2 varying among the cases, being at least 1,310 kb apart. Furthermore, the breakpoints also differed within one of the cases, being located on both the proximal and the distal side of the most centromeric probe used. Based on our three patients, as well as on a previously reported 82-year-old patient with AML M2 and idic(7)(q11) as the only chromosomal change, we suggest that this abnormality, as the sole anomaly, is associated with AML in elderly patients who display a good response to induction chemotherapy and. hence, have a favorable prognosis. Furthermore, the heterogeneous breakpoints in 7q11.2 suggest that the important functional outcome of the idic(7)(q11.2) is the genomic imbalance incurred, i.e., gain of 7p and loss of 7q material, rather than a rearrangement of a specific gene.}},
  author       = {{Johansson, Bertil and Axelsson, Per and Billström, Rolf and Strömbeck, Bodil and Arheden, Kristina and Olofsson, Tor and Cervin, Anneli and Adriansson, Magnus and Tanke, Hans J. and Mitelman, Felix and Fioretos, Thoas}},
  issn         = {{1045-2257}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{261--266}},
  publisher    = {{Wiley-Liss Inc.}},
  series       = {{Genes, Chromosomes and Cancer}},
  title        = {{Isodicentric 7p, idic(7)(q11.2), in acute myeloid}},
  url          = {{http://dx.doi.org/10.1002/1098-2264(2000)9999:9999<::AID-GCC1087>3.0.CO;2-A}},
  doi          = {{10.1002/1098-2264(2000)9999:9999<::AID-GCC1087>3.0.CO;2-A}},
  volume       = {{30}},
  year         = {{2001}},
}