Serum cystatin C is a better marker for preeclampsia than serum creatinine or serum urate
Strevens, Helena LU ; Wide-Swensson, Dag LU and Grubb, Anders LU
(2001)
In Scandinavian Journal of Clinical & Laboratory Investigation
61(7).
p.575-580
- Abstract
- Altered renal function is an essential component of the pathophysiological process in preeclampsia. The kidneys play a significant part in the turnover of most low molecular weight substances such as creatinine, urate and cystatin C. The present work was undertaken to investigate if the serum levels of these components are altered in characteristic ways in preeclampsia, and can be used to assist in the diagnosis of this condition. The serum levels were therefore determined in samples from 100 healthy women at term as well as in 45 samples of patients with preeclampsia (diastolic blood pressure >90 mmHg; urinary albumin excretion >300 mgL(-1)). The levels of all three components were significantly higher in samples from preeclamptic... (More)
- Altered renal function is an essential component of the pathophysiological process in preeclampsia. The kidneys play a significant part in the turnover of most low molecular weight substances such as creatinine, urate and cystatin C. The present work was undertaken to investigate if the serum levels of these components are altered in characteristic ways in preeclampsia, and can be used to assist in the diagnosis of this condition. The serum levels were therefore determined in samples from 100 healthy women at term as well as in 45 samples of patients with preeclampsia (diastolic blood pressure >90 mmHg; urinary albumin excretion >300 mgL(-1)). The levels of all three components were significantly higher in samples from preeclamptic patients with the mean+SD being 1.55+/-0.29 vs. 1.05+/-0.19 mg L(-1) for cystatin C, 70+/-23 vs. 56+/-9.7 micromol L(-1) for creatinine, and 413+/-128 vs. 305+/-61 micromol L(-1) for urate. Receiver operating characteristic analysis demonstrated that the serum level of cystatin C had a superior diagnostic accuracy for preeclampsia compared to those of serum urate and creatinine and that the diagnostic accuracy of serum urate was better than that of serum creatinine. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1121035
- author
- Strevens, Helena
LU
; Wide-Swensson, Dag
LU
and Grubb, Anders
LU
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scandinavian Journal of Clinical & Laboratory Investigation
- volume
- 61
- issue
- 7
- pages
- 575 - 580
- publisher
- Informa Healthcare
- external identifiers
-
- pmid:11763416
- scopus:0035232527
- ISSN
- 1502-7686
- DOI
- 10.1080/003655101753218346
- language
- English
- LU publication?
- yes
- id
- 637bd390-4d4e-403b-856c-f56d9108ed58 (old id 1121035)
- date added to LUP
- 2016-04-01 16:12:51
- date last changed
- 2023-03-28 22:08:15
@article{637bd390-4d4e-403b-856c-f56d9108ed58,
abstract = {{Altered renal function is an essential component of the pathophysiological process in preeclampsia. The kidneys play a significant part in the turnover of most low molecular weight substances such as creatinine, urate and cystatin C. The present work was undertaken to investigate if the serum levels of these components are altered in characteristic ways in preeclampsia, and can be used to assist in the diagnosis of this condition. The serum levels were therefore determined in samples from 100 healthy women at term as well as in 45 samples of patients with preeclampsia (diastolic blood pressure >90 mmHg; urinary albumin excretion >300 mgL(-1)). The levels of all three components were significantly higher in samples from preeclamptic patients with the mean+SD being 1.55+/-0.29 vs. 1.05+/-0.19 mg L(-1) for cystatin C, 70+/-23 vs. 56+/-9.7 micromol L(-1) for creatinine, and 413+/-128 vs. 305+/-61 micromol L(-1) for urate. Receiver operating characteristic analysis demonstrated that the serum level of cystatin C had a superior diagnostic accuracy for preeclampsia compared to those of serum urate and creatinine and that the diagnostic accuracy of serum urate was better than that of serum creatinine.}},
author = {{Strevens, Helena and Wide-Swensson, Dag and Grubb, Anders}},
issn = {{1502-7686}},
language = {{eng}},
number = {{7}},
pages = {{575--580}},
publisher = {{Informa Healthcare}},
series = {{Scandinavian Journal of Clinical & Laboratory Investigation}},
title = {{Serum cystatin C is a better marker for preeclampsia than serum creatinine or serum urate}},
url = {{http://dx.doi.org/10.1080/003655101753218346}},
doi = {{10.1080/003655101753218346}},
volume = {{61}},
year = {{2001}},
}