Improvement of cognitive functions after cobalamin/folate supplementation in elderly patients with dementia and elevated plasma homocysteine
(2001) In International Journal of Geriatric Psychiatry 16(6). p.609-614- Abstract
- OBJECTIVES: To investigate the effect of cobalamin/folate supplementation on cognitive function in elderly patients with dementia. METHOD: The cobalamin/folate status of the patients was evaluated by measuring plasma homocysteine, serum methylmalonic acid, serum cobalamin and blood folate. Thirty-three patients were studied and repeatedly assessed with the Mini-Mental State Examination (MMSE) and 'A short cognitive performance test for assessing memory and attention' (SKT) during vitamin substitution. RESULTS: Patients with mild-moderate dementia and elevated plasma homocysteine levels improved clinically with increased test scores after vitamin substitution, while severely demented patients and patients with normal plasma homocysteine... (More)
- OBJECTIVES: To investigate the effect of cobalamin/folate supplementation on cognitive function in elderly patients with dementia. METHOD: The cobalamin/folate status of the patients was evaluated by measuring plasma homocysteine, serum methylmalonic acid, serum cobalamin and blood folate. Thirty-three patients were studied and repeatedly assessed with the Mini-Mental State Examination (MMSE) and 'A short cognitive performance test for assessing memory and attention' (SKT) during vitamin substitution. RESULTS: Patients with mild-moderate dementia and elevated plasma homocysteine levels improved clinically with increased test scores after vitamin substitution, while severely demented patients and patients with normal plasma homocysteine levels did not improve clinically. CONCLUSIONS: Plasma homocysteine may be the best marker for detecting treatable cobalamin/folate deficiency in patients with dementia. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1122314
- author
- Nilsson, Karin ; Gustafson, Lars LU and Hultberg, Björn LU
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cobalamin, folate, homocysteine, methylmalonic acid, dementia
- in
- International Journal of Geriatric Psychiatry
- volume
- 16
- issue
- 6
- pages
- 609 - 614
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:11424170
- scopus:0034936213
- ISSN
- 1099-1166
- DOI
- 10.1002/gps.388
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Psychogeriatrics (013304000), Division of Clinical Chemistry and Pharmacology (013250300)
- id
- 732f0977-7097-45ed-b951-9d33204c5fd0 (old id 1122314)
- date added to LUP
- 2016-04-01 12:21:21
- date last changed
- 2022-01-27 02:37:33
@article{732f0977-7097-45ed-b951-9d33204c5fd0, abstract = {{OBJECTIVES: To investigate the effect of cobalamin/folate supplementation on cognitive function in elderly patients with dementia. METHOD: The cobalamin/folate status of the patients was evaluated by measuring plasma homocysteine, serum methylmalonic acid, serum cobalamin and blood folate. Thirty-three patients were studied and repeatedly assessed with the Mini-Mental State Examination (MMSE) and 'A short cognitive performance test for assessing memory and attention' (SKT) during vitamin substitution. RESULTS: Patients with mild-moderate dementia and elevated plasma homocysteine levels improved clinically with increased test scores after vitamin substitution, while severely demented patients and patients with normal plasma homocysteine levels did not improve clinically. CONCLUSIONS: Plasma homocysteine may be the best marker for detecting treatable cobalamin/folate deficiency in patients with dementia.}}, author = {{Nilsson, Karin and Gustafson, Lars and Hultberg, Björn}}, issn = {{1099-1166}}, keywords = {{cobalamin; folate; homocysteine; methylmalonic acid; dementia}}, language = {{eng}}, number = {{6}}, pages = {{609--614}}, publisher = {{John Wiley & Sons Inc.}}, series = {{International Journal of Geriatric Psychiatry}}, title = {{Improvement of cognitive functions after cobalamin/folate supplementation in elderly patients with dementia and elevated plasma homocysteine}}, url = {{http://dx.doi.org/10.1002/gps.388}}, doi = {{10.1002/gps.388}}, volume = {{16}}, year = {{2001}}, }