Metabolic effects of metformin in patients with impaired glucose tolerance
(2001) In Diabetic Medicine 18(7). p.578-583- Abstract
- AIMS: To assess the effect of metformin on insulin sensitivity, glucose tolerance and components of the metabolic syndrome in patients with impaired glucose tolerance (IGT). METHODS: Forty first-degree relatives of patients with Type 2 diabetes fulfilling WHO criteria for IGT and participating in the Botnia study in Finland were randomized to treatment with either metformin 500 mg b.i.d. or placebo for 6 months. An oral glucose tolerance test (OGTT) and a euglycaemic hyperinsulinaemic clamp in combination with indirect calorimetry was performed at 0 and 6 months. The patients were followed after stopping treatment for another 6 months in an open trial and a repeat OGTT was performed at 12 months. RESULTS: Metformin treatment resulted in a... (More)
- AIMS: To assess the effect of metformin on insulin sensitivity, glucose tolerance and components of the metabolic syndrome in patients with impaired glucose tolerance (IGT). METHODS: Forty first-degree relatives of patients with Type 2 diabetes fulfilling WHO criteria for IGT and participating in the Botnia study in Finland were randomized to treatment with either metformin 500 mg b.i.d. or placebo for 6 months. An oral glucose tolerance test (OGTT) and a euglycaemic hyperinsulinaemic clamp in combination with indirect calorimetry was performed at 0 and 6 months. The patients were followed after stopping treatment for another 6 months in an open trial and a repeat OGTT was performed at 12 months. RESULTS: Metformin treatment resulted in a 20% improvement in insulin-stimulated glucose metabolism (from 28.7 +/- 13 to 34.4 +/- 10.7 micromol/kg fat-free mass (FFM)/min) compared with placebo (P = 0.01), which was primarily due to an increase in glucose oxidation (from 16.6 +/- 3.6 to 19.1 +/- 4.4 micromol/kg FFM; P = 0.03) These changes were associated with a minimal improvement in glucose tolerance, which was maintained after 12 months. CONCLUSIONS: Metformin improves insulin sensitivity in subjects with IGT primarily by reversal of the glucose fatty acid cycle. Obviously large multicentre studies are needed to establish whether these effects are sufficient to prevent progression to manifest Type 2 diabetes and associated cardiovascular morbidity and mortality. Diabet. Med. 18, 578-583 (2001) (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1122529
- author
- Lehtovirta, M ; Forsen, B ; Gullstrom, M ; Haggblom, M ; Eriksson, J G ; Taskinen, M R and Groop, Leif LU
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetic Medicine
- volume
- 18
- issue
- 7
- pages
- 578 - 583
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:11553189
- scopus:0034851709
- ISSN
- 1464-5491
- DOI
- 10.1046/j.1464-5491.2001.00539.x
- language
- English
- LU publication?
- yes
- id
- e80e551d-eab4-4757-bd53-0025f59b207d (old id 1122529)
- date added to LUP
- 2016-04-01 15:35:48
- date last changed
- 2024-03-28 08:09:44
@article{e80e551d-eab4-4757-bd53-0025f59b207d,
abstract = {{AIMS: To assess the effect of metformin on insulin sensitivity, glucose tolerance and components of the metabolic syndrome in patients with impaired glucose tolerance (IGT). METHODS: Forty first-degree relatives of patients with Type 2 diabetes fulfilling WHO criteria for IGT and participating in the Botnia study in Finland were randomized to treatment with either metformin 500 mg b.i.d. or placebo for 6 months. An oral glucose tolerance test (OGTT) and a euglycaemic hyperinsulinaemic clamp in combination with indirect calorimetry was performed at 0 and 6 months. The patients were followed after stopping treatment for another 6 months in an open trial and a repeat OGTT was performed at 12 months. RESULTS: Metformin treatment resulted in a 20% improvement in insulin-stimulated glucose metabolism (from 28.7 +/- 13 to 34.4 +/- 10.7 micromol/kg fat-free mass (FFM)/min) compared with placebo (P = 0.01), which was primarily due to an increase in glucose oxidation (from 16.6 +/- 3.6 to 19.1 +/- 4.4 micromol/kg FFM; P = 0.03) These changes were associated with a minimal improvement in glucose tolerance, which was maintained after 12 months. CONCLUSIONS: Metformin improves insulin sensitivity in subjects with IGT primarily by reversal of the glucose fatty acid cycle. Obviously large multicentre studies are needed to establish whether these effects are sufficient to prevent progression to manifest Type 2 diabetes and associated cardiovascular morbidity and mortality. Diabet. Med. 18, 578-583 (2001)}},
author = {{Lehtovirta, M and Forsen, B and Gullstrom, M and Haggblom, M and Eriksson, J G and Taskinen, M R and Groop, Leif}},
issn = {{1464-5491}},
language = {{eng}},
number = {{7}},
pages = {{578--583}},
publisher = {{Wiley-Blackwell}},
series = {{Diabetic Medicine}},
title = {{Metabolic effects of metformin in patients with impaired glucose tolerance}},
url = {{http://dx.doi.org/10.1046/j.1464-5491.2001.00539.x}},
doi = {{10.1046/j.1464-5491.2001.00539.x}},
volume = {{18}},
year = {{2001}},
}