Time course of striatal DeltaFosB-like immunoreactivity and prodynorphin mRNA levels after discontinuation of chronic dopaminomimetic treatment.
Andersson, M ; Westin, J E and Cenci Nilsson, Angela LU
(2003)
In European Journal of Neuroscience
17(3).
p.661-666
- Abstract
- DFosB-like proteins are particularly stable transcription factors that accumulate in the brain in response to chronic perturbations. In this study we have compared the time-course of striatal FosB/DFosB-like immunoreactivity and prodynorphin mRNA expression after discontinuation of chronic cocaine treatment to intact rats and chronic L-DOPA treatment to unilaterally 6-hydroxydopamine (6-OHDA)
lesioned rats. The animals were killed between 3 h and 16 days after the last drug injection. In both treatment paradigms, the druginduced FosB/DFosB immunoreactivity remained significantly elevated in the caudate putamen even at the longest withdrawal period examined. The concomitant upregulation of prodynorphin mRNA, a target of DFosB,... (More) - DFosB-like proteins are particularly stable transcription factors that accumulate in the brain in response to chronic perturbations. In this study we have compared the time-course of striatal FosB/DFosB-like immunoreactivity and prodynorphin mRNA expression after discontinuation of chronic cocaine treatment to intact rats and chronic L-DOPA treatment to unilaterally 6-hydroxydopamine (6-OHDA)
lesioned rats. The animals were killed between 3 h and 16 days after the last drug injection. In both treatment paradigms, the druginduced FosB/DFosB immunoreactivity remained significantly elevated in the caudate putamen even at the longest withdrawal period examined. The concomitant upregulation of prodynorphin mRNA, a target of DFosB, paralleled the time-course of DFosB-like immunoreactivity in the 6-OHDA-lesion/L-DOPA model, but was more transient in animals treated with cocaine. These results suggest that DFosB-like proteins have exceptional in vivo stability. In the dopamine-denervated striatum, these proteins may exert
sustained effects on the expression of their target genes long after discontinuation of L-DOPA pharmacotherapy. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/112333
- author
- Andersson, M
; Westin, J E
and Cenci Nilsson, Angela
LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- motor stereotypy, immediate-early genes, drugs of abuse, dyskinesia, Parkinson’s disease
- in
- European Journal of Neuroscience
- volume
- 17
- issue
- 3
- pages
- 661 - 666
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000180899600024
- pmid:12581184
- scopus:0037330231
- ISSN
- 1460-9568
- DOI
- 10.1046/j.1460-9568.2003.02469.x
- language
- English
- LU publication?
- yes
- id
- 60440a5c-f21e-4734-92bc-561832f6484a (old id 112333)
- date added to LUP
- 2016-04-01 12:38:05
- date last changed
- 2022-03-06 02:11:13
@article{60440a5c-f21e-4734-92bc-561832f6484a,
abstract = {{DFosB-like proteins are particularly stable transcription factors that accumulate in the brain in response to chronic perturbations. In this study we have compared the time-course of striatal FosB/DFosB-like immunoreactivity and prodynorphin mRNA expression after discontinuation of chronic cocaine treatment to intact rats and chronic L-DOPA treatment to unilaterally 6-hydroxydopamine (6-OHDA)<br/><br>
lesioned rats. The animals were killed between 3 h and 16 days after the last drug injection. In both treatment paradigms, the druginduced FosB/DFosB immunoreactivity remained significantly elevated in the caudate putamen even at the longest withdrawal period examined. The concomitant upregulation of prodynorphin mRNA, a target of DFosB, paralleled the time-course of DFosB-like immunoreactivity in the 6-OHDA-lesion/L-DOPA model, but was more transient in animals treated with cocaine. These results suggest that DFosB-like proteins have exceptional in vivo stability. In the dopamine-denervated striatum, these proteins may exert<br/><br>
sustained effects on the expression of their target genes long after discontinuation of L-DOPA pharmacotherapy.}},
author = {{Andersson, M and Westin, J E and Cenci Nilsson, Angela}},
issn = {{1460-9568}},
keywords = {{motor stereotypy; immediate-early genes; drugs of abuse; dyskinesia; Parkinson’s disease}},
language = {{eng}},
number = {{3}},
pages = {{661--666}},
publisher = {{Wiley-Blackwell}},
series = {{European Journal of Neuroscience}},
title = {{Time course of striatal DeltaFosB-like immunoreactivity and prodynorphin mRNA levels after discontinuation of chronic dopaminomimetic treatment.}},
url = {{https://lup.lub.lu.se/search/files/3003265/623707.pdf}},
doi = {{10.1046/j.1460-9568.2003.02469.x}},
volume = {{17}},
year = {{2003}},
}