A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs.
(2003) In Biochemical and Biophysical Research Communications 301(2). p.406-410- Abstract
- Fatty acids, which are essential nutritional components, are also involved in cardiovascular and metabolic diseases. Here we report a human cell surface receptor that we name free fatty acid receptor (FFAR), because it is specifically activated by medium to long-chain free fatty acids. The receptor belongs to the class of seven-transmembrane, G-protein coupled receptors (GPCRs) and also mediates responses to antidiabetic drugs of the thiazolidinedione type. It is expressed in skeletal muscle, heart, liver, and pancreatic β-cells. Stimulation of FFAR increases the intracellular calcium concentration in cells expressing the receptor in a native (pancreatic β-cell line) or in a recombinant form. In view of the nature of the activating... (More)
- Fatty acids, which are essential nutritional components, are also involved in cardiovascular and metabolic diseases. Here we report a human cell surface receptor that we name free fatty acid receptor (FFAR), because it is specifically activated by medium to long-chain free fatty acids. The receptor belongs to the class of seven-transmembrane, G-protein coupled receptors (GPCRs) and also mediates responses to antidiabetic drugs of the thiazolidinedione type. It is expressed in skeletal muscle, heart, liver, and pancreatic β-cells. Stimulation of FFAR increases the intracellular calcium concentration in cells expressing the receptor in a native (pancreatic β-cell line) or in a recombinant form. In view of the nature of the activating substances, their physiological role in the body, and the tissue distribution of FFAR we suggest the term “nutrient sensing receptor” for receptors acting at the interface between dietary components and signalling molecules. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/112366
- author
- Kotarsky, Knut LU ; Nilsson, Niclas LU ; Flodgren, Erik LU ; Owman, Christer LU and Olde, Björn LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Reverse pharmacology, Arteriosclerosis, Obesity, Diabetes, Thiazolidinediones, Fatty acid, GPR40, Receptor, Cell surface, Preclinical, Drug evaluation
- in
- Biochemical and Biophysical Research Communications
- volume
- 301
- issue
- 2
- pages
- 406 - 410
- publisher
- Elsevier
- external identifiers
-
- wos:000181099100023
- pmid:12565875
- scopus:0037423719
- ISSN
- 1090-2104
- DOI
- 10.1016/S0006-291X(02)03064-4
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Molecular Neurobiology (0131000140), Department of Experimental Medical Science (013210000), Mucosal Immunology (013212072), Immunology (013212020), Drug Target Discovery (013212045)
- id
- 9fc1526d-cd60-41e1-980a-a72aba55fa14 (old id 112366)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12565875&dopt=Abstract
- date added to LUP
- 2016-04-01 16:15:07
- date last changed
- 2022-03-14 23:08:25
@article{9fc1526d-cd60-41e1-980a-a72aba55fa14, abstract = {{Fatty acids, which are essential nutritional components, are also involved in cardiovascular and metabolic diseases. Here we report a human cell surface receptor that we name free fatty acid receptor (FFAR), because it is specifically activated by medium to long-chain free fatty acids. The receptor belongs to the class of seven-transmembrane, G-protein coupled receptors (GPCRs) and also mediates responses to antidiabetic drugs of the thiazolidinedione type. It is expressed in skeletal muscle, heart, liver, and pancreatic β-cells. Stimulation of FFAR increases the intracellular calcium concentration in cells expressing the receptor in a native (pancreatic β-cell line) or in a recombinant form. In view of the nature of the activating substances, their physiological role in the body, and the tissue distribution of FFAR we suggest the term “nutrient sensing receptor” for receptors acting at the interface between dietary components and signalling molecules.}}, author = {{Kotarsky, Knut and Nilsson, Niclas and Flodgren, Erik and Owman, Christer and Olde, Björn}}, issn = {{1090-2104}}, keywords = {{Reverse pharmacology; Arteriosclerosis; Obesity; Diabetes; Thiazolidinediones; Fatty acid; GPR40; Receptor; Cell surface; Preclinical; Drug evaluation}}, language = {{eng}}, number = {{2}}, pages = {{406--410}}, publisher = {{Elsevier}}, series = {{Biochemical and Biophysical Research Communications}}, title = {{A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs.}}, url = {{http://dx.doi.org/10.1016/S0006-291X(02)03064-4}}, doi = {{10.1016/S0006-291X(02)03064-4}}, volume = {{301}}, year = {{2003}}, }