A study of the association between exercise-induced wheeze and exercise versus methacholine-induced bronchoconstriction in adolescents
(2002) In Pediatric Allergy and Immunology 13(3). p.203-208- Abstract
- Among asthmatics, exercise-induced wheeze (EIW) is a frequent symptom, and 40-77% of asthmatics demonstrate exercise-induced bronchoconstriction (EIB). In the North-Trondelag population-based survey of 8,571 adolescents (YOUNG-HUNT), 26% reported wheeze during the previous 12 months (current wheeze). Of those subjects, 50% reported EIW. The aim of the present study was to investigate the association between EIW and EIB in randomly selected adolescents with EIW as the only or predominant asthma-like symptom, and to relate our findings to results from methacholine bronchoprovocation tests (MT) and measurements of exhaled nitric oxide (ENO). Sixty-three subjects with current wheeze induced by exercise, but not by allergen exposure, were... (More)
- Among asthmatics, exercise-induced wheeze (EIW) is a frequent symptom, and 40-77% of asthmatics demonstrate exercise-induced bronchoconstriction (EIB). In the North-Trondelag population-based survey of 8,571 adolescents (YOUNG-HUNT), 26% reported wheeze during the previous 12 months (current wheeze). Of those subjects, 50% reported EIW. The aim of the present study was to investigate the association between EIW and EIB in randomly selected adolescents with EIW as the only or predominant asthma-like symptom, and to relate our findings to results from methacholine bronchoprovocation tests (MT) and measurements of exhaled nitric oxide (ENO). Sixty-three subjects with current wheeze induced by exercise, but not by allergen exposure, were investigated using a treadmill exercise test (ET) and measurements of ENO. Fifty-eight subjects completed a MT on a separate study day. EIB was defined as a fall of >or= 10% in the forced expiratory volume in 1 second (FEV1) after exercise (DeltaFEV1%ex). Twenty-one subjects (33%) had EIB and 33 (57%) had a positive MT. The degree of reported dyspnea during the ET was not correlated to the DeltaFEV1%ex. The correlation between EIB and methacholine-induced bronchoconstriction (MIB) was poor, and the DeltaFEV1%ex was more pronounced in smokers than in non-smokers. Moreover, ENO was not increased in subjects with positive vs. negative ET. Hence, EIW, when reported as the only or predominant asthma-like symptom, was linked to EIB in only one-third of the patients. We conclude that EIW is a poor predictor of EIB in epidemiological studies. The poor correlation between EIB and MIB indicates that these two tests measure different mechanisms of bronchial hyper-responsiveness. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1123974
- author
- Henriksen, Anne Hildur ; Tveit, Kjerst Hafstad ; Holmen, Turid Lingaas ; Sue-Chu, Malcolm and Bjermer, Leif LU
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Pediatric Allergy and Immunology
- volume
- 13
- issue
- 3
- pages
- 203 - 208
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:12144643
- scopus:0036023682
- ISSN
- 0905-6157
- DOI
- 10.1034/j.1399-3038.2002.01034.x
- language
- English
- LU publication?
- no
- id
- 6a200eb1-c68b-439c-94d2-6615119ce2db (old id 1123974)
- date added to LUP
- 2016-04-01 16:30:45
- date last changed
- 2022-02-05 08:43:02
@article{6a200eb1-c68b-439c-94d2-6615119ce2db,
abstract = {{Among asthmatics, exercise-induced wheeze (EIW) is a frequent symptom, and 40-77% of asthmatics demonstrate exercise-induced bronchoconstriction (EIB). In the North-Trondelag population-based survey of 8,571 adolescents (YOUNG-HUNT), 26% reported wheeze during the previous 12 months (current wheeze). Of those subjects, 50% reported EIW. The aim of the present study was to investigate the association between EIW and EIB in randomly selected adolescents with EIW as the only or predominant asthma-like symptom, and to relate our findings to results from methacholine bronchoprovocation tests (MT) and measurements of exhaled nitric oxide (ENO). Sixty-three subjects with current wheeze induced by exercise, but not by allergen exposure, were investigated using a treadmill exercise test (ET) and measurements of ENO. Fifty-eight subjects completed a MT on a separate study day. EIB was defined as a fall of >or= 10% in the forced expiratory volume in 1 second (FEV1) after exercise (DeltaFEV1%ex). Twenty-one subjects (33%) had EIB and 33 (57%) had a positive MT. The degree of reported dyspnea during the ET was not correlated to the DeltaFEV1%ex. The correlation between EIB and methacholine-induced bronchoconstriction (MIB) was poor, and the DeltaFEV1%ex was more pronounced in smokers than in non-smokers. Moreover, ENO was not increased in subjects with positive vs. negative ET. Hence, EIW, when reported as the only or predominant asthma-like symptom, was linked to EIB in only one-third of the patients. We conclude that EIW is a poor predictor of EIB in epidemiological studies. The poor correlation between EIB and MIB indicates that these two tests measure different mechanisms of bronchial hyper-responsiveness.}},
author = {{Henriksen, Anne Hildur and Tveit, Kjerst Hafstad and Holmen, Turid Lingaas and Sue-Chu, Malcolm and Bjermer, Leif}},
issn = {{0905-6157}},
language = {{eng}},
number = {{3}},
pages = {{203--208}},
publisher = {{Wiley-Blackwell}},
series = {{Pediatric Allergy and Immunology}},
title = {{A study of the association between exercise-induced wheeze and exercise versus methacholine-induced bronchoconstriction in adolescents}},
url = {{http://dx.doi.org/10.1034/j.1399-3038.2002.01034.x}},
doi = {{10.1034/j.1399-3038.2002.01034.x}},
volume = {{13}},
year = {{2002}},
}