Xylylated dimers of putrescine and polyamines: influence of the polyamine backbone on spermidine transport inhibition
(2003) In Bioorganic & Medicinal Chemistry Letters 13(19). p.3267-3271- Abstract
- Dimeric norspermidine and spermidine derivatives are strong competitive inhibitors of polyamine transport. A xylyl tether was used for the dimerization of various triamines and spermine via a secondary amino group, and of putrescine via an ether or an amino group. Dimerization of putrescine moieties potentiates their ability to compete against spermidine transport to a much greater extent than for triamine dimers.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1128080
- author
- Covassin, Laurence ; Desjardins, Michel ; Soulet, Denis LU ; Charest-Gaudreault, Rene ; Audette, Marie and Poulin, Richard
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Bioorganic & Medicinal Chemistry Letters
- volume
- 13
- issue
- 19
- pages
- 3267 - 3271
- publisher
- Elsevier
- external identifiers
-
- pmid:12951106
- scopus:0042832967
- ISSN
- 0960-894X
- DOI
- 10.1016/S0960-894X(03)00668-1
- language
- English
- LU publication?
- no
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)
- id
- 071b5ce6-5ad6-4071-ac26-28492069da2b (old id 1128080)
- date added to LUP
- 2016-04-01 12:14:02
- date last changed
- 2022-01-27 00:49:37
@article{071b5ce6-5ad6-4071-ac26-28492069da2b, abstract = {{Dimeric norspermidine and spermidine derivatives are strong competitive inhibitors of polyamine transport. A xylyl tether was used for the dimerization of various triamines and spermine via a secondary amino group, and of putrescine via an ether or an amino group. Dimerization of putrescine moieties potentiates their ability to compete against spermidine transport to a much greater extent than for triamine dimers.}}, author = {{Covassin, Laurence and Desjardins, Michel and Soulet, Denis and Charest-Gaudreault, Rene and Audette, Marie and Poulin, Richard}}, issn = {{0960-894X}}, language = {{eng}}, number = {{19}}, pages = {{3267--3271}}, publisher = {{Elsevier}}, series = {{Bioorganic & Medicinal Chemistry Letters}}, title = {{Xylylated dimers of putrescine and polyamines: influence of the polyamine backbone on spermidine transport inhibition}}, url = {{http://dx.doi.org/10.1016/S0960-894X(03)00668-1}}, doi = {{10.1016/S0960-894X(03)00668-1}}, volume = {{13}}, year = {{2003}}, }