Mouse mammary tumor virus-like RNA transcripts and DNA are found in affected cells of human breast cancer
(2004) In Clinical Cancer Research 10(21). p.7284-7284- Abstract
- Identifiable risk factors for the development of breast cancer include age, diet, family history, and lifetime estrogen exposure. An infectious agent (mouse mammary tumor virus; MMTV) is known to cause murine breast tumors and may be involved in the pathogenesis of human disease. Multiple studies have detected MMTV-like sequences in 30 to 60% of breast cancer samples and up to 1.8% of samples from normal breast. Using in situ PCR of MMTV-like sequences of formalin-fixed, paraffin-embedded breast tissue, viral sequences have been located in cancerous epithelial cells in breast acini of male and female breast tumors, but not in adjacent nonmalignant cells. MMTV-like sequences were also located in the epithelial cells of male gynecomastia... (More)
- Identifiable risk factors for the development of breast cancer include age, diet, family history, and lifetime estrogen exposure. An infectious agent (mouse mammary tumor virus; MMTV) is known to cause murine breast tumors and may be involved in the pathogenesis of human disease. Multiple studies have detected MMTV-like sequences in 30 to 60% of breast cancer samples and up to 1.8% of samples from normal breast. Using in situ PCR of MMTV-like sequences of formalin-fixed, paraffin-embedded breast tissue, viral sequences have been located in cancerous epithelial cells in breast acini of male and female breast tumors, but not in adjacent nonmalignant cells. MMTV-like sequences were also located in the epithelial cells of male gynecomastia samples. Using reverse transcriptase in situ PCR, RNA transcripts from the env gene were also detected within cancerous epithelial cells of 78% of DNA-positive tumors, 80% of gynecomastia samples, and 0% of normal tissues screened. This suggests the virus may be replicating in these cells. The epidemiologic and histopathological data are consistent with the association of an MMTV-like virus with breast cancers in men and women. The association with gynecomastia, a benign, possibly premalignant condition suggests hormonal influences, rather than cancer per se, may be the dominant factor in determining viral presence and replication. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1130009
- author
- Ford, Caroline LU ; Faedo, Margaret and Rawlinson, William D
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Clinical Cancer Research
- volume
- 10
- issue
- 21
- pages
- 7284 - 7284
- publisher
- American Association for Cancer Research
- external identifiers
-
- pmid:15534103
- scopus:4444248395
- pmid:15534103
- ISSN
- 1078-0432
- DOI
- 10.1158/1078-0432.CCR-04-0767
- language
- English
- LU publication?
- yes
- id
- 0793f470-883b-494a-981d-9125579917a5 (old id 1130009)
- date added to LUP
- 2016-04-01 12:18:10
- date last changed
- 2022-05-19 03:53:29
@article{0793f470-883b-494a-981d-9125579917a5,
abstract = {{Identifiable risk factors for the development of breast cancer include age, diet, family history, and lifetime estrogen exposure. An infectious agent (mouse mammary tumor virus; MMTV) is known to cause murine breast tumors and may be involved in the pathogenesis of human disease. Multiple studies have detected MMTV-like sequences in 30 to 60% of breast cancer samples and up to 1.8% of samples from normal breast. Using in situ PCR of MMTV-like sequences of formalin-fixed, paraffin-embedded breast tissue, viral sequences have been located in cancerous epithelial cells in breast acini of male and female breast tumors, but not in adjacent nonmalignant cells. MMTV-like sequences were also located in the epithelial cells of male gynecomastia samples. Using reverse transcriptase in situ PCR, RNA transcripts from the env gene were also detected within cancerous epithelial cells of 78% of DNA-positive tumors, 80% of gynecomastia samples, and 0% of normal tissues screened. This suggests the virus may be replicating in these cells. The epidemiologic and histopathological data are consistent with the association of an MMTV-like virus with breast cancers in men and women. The association with gynecomastia, a benign, possibly premalignant condition suggests hormonal influences, rather than cancer per se, may be the dominant factor in determining viral presence and replication.}},
author = {{Ford, Caroline and Faedo, Margaret and Rawlinson, William D}},
issn = {{1078-0432}},
language = {{eng}},
number = {{21}},
pages = {{7284--7284}},
publisher = {{American Association for Cancer Research}},
series = {{Clinical Cancer Research}},
title = {{Mouse mammary tumor virus-like RNA transcripts and DNA are found in affected cells of human breast cancer}},
url = {{http://dx.doi.org/10.1158/1078-0432.CCR-04-0767}},
doi = {{10.1158/1078-0432.CCR-04-0767}},
volume = {{10}},
year = {{2004}},
}