Fluoxetine potentiates chloroquine and mefloquine effect on multidrug-resistant Plasmodium falciparum in vitro
Khairul, Mohd Fadzli Mustaffa ; Tan Grahn, Hooi Min LU
; Low, Jen Hou
; Nasriyyah, Che Husin Che
; A'shikin, Azahri Noor
; Norazmi, Mohd Nor
; Ravichandran, Manickam
and Raju, Suraparaju Sivachandra
(2006)
In Japanese Journal of Infectious Diseases
59(5).
p.329-331
- Abstract
- Fluoxetine (FLX), a P-glycoprotein inhibitor with antimalarial activity, is promising candidate for reversing chloroquine/mefloquine (CQ/MQ) resistance. The Dd2 strain of CQ- and MQ-resistant Plasmodium falciparum was synchronized and assayed with various concentrations of CQ/MQ individually and in combination with FLX or verapamil (VPL). Our results indicated the 50% inhibitory concentration values of CQ and MQ were greatly lowered when FLX was used simultaneously. Isobolograms indicated that CQ-FLX combinations are more synergistic (mean fractional inhibitory concentration [FIC] index 0.55) than MQ-FLX (mean FIC index 0.64), and their synergistic effect was better than or at par with CQ-VPL (mean FIC index 0.88) and MQ-VPL (mean FIC... (More)
- Fluoxetine (FLX), a P-glycoprotein inhibitor with antimalarial activity, is promising candidate for reversing chloroquine/mefloquine (CQ/MQ) resistance. The Dd2 strain of CQ- and MQ-resistant Plasmodium falciparum was synchronized and assayed with various concentrations of CQ/MQ individually and in combination with FLX or verapamil (VPL). Our results indicated the 50% inhibitory concentration values of CQ and MQ were greatly lowered when FLX was used simultaneously. Isobolograms indicated that CQ-FLX combinations are more synergistic (mean fractional inhibitory concentration [FIC] index 0.55) than MQ-FLX (mean FIC index 0.64), and their synergistic effect was better than or at par with CQ-VPL (mean FIC index 0.88) and MQ-VPL (mean FIC index 0.60) combinations. We conclude that the FLX potentiates the CQ and MQ response on multidrug-resistant P. falciparum at clinically achievable concentrations. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1135905
- author
- Khairul, Mohd Fadzli Mustaffa
; Tan Grahn, Hooi Min
LU
; Low, Jen Hou
; Nasriyyah, Che Husin Che
; A'shikin, Azahri Noor
; Norazmi, Mohd Nor
; Ravichandran, Manickam
and Raju, Suraparaju Sivachandra
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Japanese Journal of Infectious Diseases
- volume
- 59
- issue
- 5
- pages
- 329 - 331
- publisher
- National Institute of Infectious Diseases. (Tokyo)
- external identifiers
-
- pmid:17060702
- scopus:33750487144
- ISSN
- 1344-6304
- language
- English
- LU publication?
- yes
- id
- 480ffe81-1cda-4547-864f-3c18d16d2a9b (old id 1135905)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/17060702
- http://www.nih.go.jp/JJID/59/329.pdf
- date added to LUP
- 2016-04-01 17:03:01
- date last changed
- 2022-04-15 08:53:00
@article{480ffe81-1cda-4547-864f-3c18d16d2a9b,
abstract = {{Fluoxetine (FLX), a P-glycoprotein inhibitor with antimalarial activity, is promising candidate for reversing chloroquine/mefloquine (CQ/MQ) resistance. The Dd2 strain of CQ- and MQ-resistant Plasmodium falciparum was synchronized and assayed with various concentrations of CQ/MQ individually and in combination with FLX or verapamil (VPL). Our results indicated the 50% inhibitory concentration values of CQ and MQ were greatly lowered when FLX was used simultaneously. Isobolograms indicated that CQ-FLX combinations are more synergistic (mean fractional inhibitory concentration [FIC] index 0.55) than MQ-FLX (mean FIC index 0.64), and their synergistic effect was better than or at par with CQ-VPL (mean FIC index 0.88) and MQ-VPL (mean FIC index 0.60) combinations. We conclude that the FLX potentiates the CQ and MQ response on multidrug-resistant P. falciparum at clinically achievable concentrations.}},
author = {{Khairul, Mohd Fadzli Mustaffa and Tan Grahn, Hooi Min and Low, Jen Hou and Nasriyyah, Che Husin Che and A'shikin, Azahri Noor and Norazmi, Mohd Nor and Ravichandran, Manickam and Raju, Suraparaju Sivachandra}},
issn = {{1344-6304}},
language = {{eng}},
number = {{5}},
pages = {{329--331}},
publisher = {{National Institute of Infectious Diseases. (Tokyo)}},
series = {{Japanese Journal of Infectious Diseases}},
title = {{Fluoxetine potentiates chloroquine and mefloquine effect on multidrug-resistant Plasmodium falciparum in vitro}},
url = {{http://www.ncbi.nlm.nih.gov/pubmed/17060702}},
volume = {{59}},
year = {{2006}},
}