Antibodies against oxidized low-density lipoprotein for the treatment of vulnerable plaques
(2006) In Current Opinion in Investigational Drugs 7.- Abstract
- Inflammation caused by the accumulation of oxidized low-density lipoprotein (oxLDL) in the arterial wall is a key factor in the development of atherosclerosis. Accumulating evidence suggests that adaptive immune responses to oxLDL are of major importance in regulating the inflammatory response, and that humoral immunity largely has a protective effect in this process. This concept is supported by animal studies demonstrating that treatment with antibodies against oxLDL inhibits atherosclerosis. Human antibodies with high affinity and specificity for epitopes on oxLDL have been developed and are now, after appropriate safety testing and non-clinical toxicology, ready to be tested in humans. Patients that may benefit front antibody treatment... (More)
- Inflammation caused by the accumulation of oxidized low-density lipoprotein (oxLDL) in the arterial wall is a key factor in the development of atherosclerosis. Accumulating evidence suggests that adaptive immune responses to oxLDL are of major importance in regulating the inflammatory response, and that humoral immunity largely has a protective effect in this process. This concept is supported by animal studies demonstrating that treatment with antibodies against oxLDL inhibits atherosclerosis. Human antibodies with high affinity and specificity for epitopes on oxLDL have been developed and are now, after appropriate safety testing and non-clinical toxicology, ready to be tested in humans. Patients that may benefit front antibody treatment are most likely to be high-risk individuals in which conventional treatments, including lipid-lowering statins, do not provide sufficient protection. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1135999
- author
- Nilsson, Jan LU ; Glaser, S and Carlsson, R
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Current Opinion in Investigational Drugs
- volume
- 7
- article number
- 815
- publisher
- BioMed Central (BMC)
- external identifiers
-
- scopus:33748672080
- ISSN
- 2040-3429
- language
- English
- LU publication?
- yes
- id
- 5fea7299-829d-4073-bdb3-a3cd68975aa7 (old id 1135999)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/17002259
- date added to LUP
- 2016-04-01 11:45:17
- date last changed
- 2022-01-26 17:45:31
@article{5fea7299-829d-4073-bdb3-a3cd68975aa7,
abstract = {{Inflammation caused by the accumulation of oxidized low-density lipoprotein (oxLDL) in the arterial wall is a key factor in the development of atherosclerosis. Accumulating evidence suggests that adaptive immune responses to oxLDL are of major importance in regulating the inflammatory response, and that humoral immunity largely has a protective effect in this process. This concept is supported by animal studies demonstrating that treatment with antibodies against oxLDL inhibits atherosclerosis. Human antibodies with high affinity and specificity for epitopes on oxLDL have been developed and are now, after appropriate safety testing and non-clinical toxicology, ready to be tested in humans. Patients that may benefit front antibody treatment are most likely to be high-risk individuals in which conventional treatments, including lipid-lowering statins, do not provide sufficient protection.}},
author = {{Nilsson, Jan and Glaser, S and Carlsson, R}},
issn = {{2040-3429}},
language = {{eng}},
publisher = {{BioMed Central (BMC)}},
series = {{Current Opinion in Investigational Drugs}},
title = {{Antibodies against oxidized low-density lipoprotein for the treatment of vulnerable plaques}},
url = {{http://www.ncbi.nlm.nih.gov/pubmed/17002259}},
volume = {{7}},
year = {{2006}},
}