Contrast media as markers of GFR
(2002) In European Radiology 12(2). p.475-484- Abstract
- Determination of the glomerular filtration rate (GFR) is generally considered as the most important parameter of quantifying renal function. The GFR is determined as renal or plasma clearance of an ideal filtration marker which is freely filtered by the kidney, does not undergo metabolism, tubular secretion or absorption. Markers that fulfil these demands are inulin, 51Cr-EDTA, 99mTc-DTPA, labelled or unlabelled contrast media. The renal clearance of inulin is the classic reference method for estimation of the GFR. This method is however not practical for routine clinical purposes. Radionucleids have therefore been used as alternative filtration markers since the 60s. Drawbacks related to radiation exposure especially in children and... (More)
- Determination of the glomerular filtration rate (GFR) is generally considered as the most important parameter of quantifying renal function. The GFR is determined as renal or plasma clearance of an ideal filtration marker which is freely filtered by the kidney, does not undergo metabolism, tubular secretion or absorption. Markers that fulfil these demands are inulin, 51Cr-EDTA, 99mTc-DTPA, labelled or unlabelled contrast media. The renal clearance of inulin is the classic reference method for estimation of the GFR. This method is however not practical for routine clinical purposes. Radionucleids have therefore been used as alternative filtration markers since the 60s. Drawbacks related to radiation exposure especially in children and pregnant women and the safety in handling radiolabelled markers have led to an increasing interest in using non-radioactive markers. The development of simple and reliable methods to determine the concentration of contrast media in plasma and urine, such as high-performance liquid chromatography (HPLC) and X-ray fluorescence analysis have made this possible. The non-ionic low osmolar contrast medium iohexol has become the most commonly used contrast medium for GFR measurements in Europe. However, other contrast media with similar pharmacokinetics may be equally suitable as GFR markers. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/115548
- author
- Frennby, Bo LU and Sterner, Gunnar LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Inulin: diagnostic use, Kidney: physiology, Female, Glomerular Filtration Rate, Human, Child, Chromium Radioisotopes: diagnostic use, Contrast Media, Edetic Acid: diagnostic use, Male, Models, Theoretical, Pregnancy, Radiopharmaceuticals: diagnostic use, Technetium Tc 99m Pentetate: diagnostic use
- in
- European Radiology
- volume
- 12
- issue
- 2
- pages
- 475 - 484
- publisher
- Springer
- external identifiers
-
- wos:000174127700033
- pmid:11870453
- scopus:0036484461
- pmid:11870453
- ISSN
- 0938-7994
- DOI
- 10.1007/s003300100864
- language
- English
- LU publication?
- yes
- id
- 1f23223d-ab37-4364-a4a0-2b1c39c3986c (old id 115548)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11870453&dopt=Abstract
- date added to LUP
- 2016-04-04 08:30:29
- date last changed
- 2022-02-05 23:59:55
@article{1f23223d-ab37-4364-a4a0-2b1c39c3986c, abstract = {{Determination of the glomerular filtration rate (GFR) is generally considered as the most important parameter of quantifying renal function. The GFR is determined as renal or plasma clearance of an ideal filtration marker which is freely filtered by the kidney, does not undergo metabolism, tubular secretion or absorption. Markers that fulfil these demands are inulin, 51Cr-EDTA, 99mTc-DTPA, labelled or unlabelled contrast media. The renal clearance of inulin is the classic reference method for estimation of the GFR. This method is however not practical for routine clinical purposes. Radionucleids have therefore been used as alternative filtration markers since the 60s. Drawbacks related to radiation exposure especially in children and pregnant women and the safety in handling radiolabelled markers have led to an increasing interest in using non-radioactive markers. The development of simple and reliable methods to determine the concentration of contrast media in plasma and urine, such as high-performance liquid chromatography (HPLC) and X-ray fluorescence analysis have made this possible. The non-ionic low osmolar contrast medium iohexol has become the most commonly used contrast medium for GFR measurements in Europe. However, other contrast media with similar pharmacokinetics may be equally suitable as GFR markers.}}, author = {{Frennby, Bo and Sterner, Gunnar}}, issn = {{0938-7994}}, keywords = {{Inulin: diagnostic use; Kidney: physiology; Female; Glomerular Filtration Rate; Human; Child; Chromium Radioisotopes: diagnostic use; Contrast Media; Edetic Acid: diagnostic use; Male; Models; Theoretical; Pregnancy; Radiopharmaceuticals: diagnostic use; Technetium Tc 99m Pentetate: diagnostic use}}, language = {{eng}}, number = {{2}}, pages = {{475--484}}, publisher = {{Springer}}, series = {{European Radiology}}, title = {{Contrast media as markers of GFR}}, url = {{http://dx.doi.org/10.1007/s003300100864}}, doi = {{10.1007/s003300100864}}, volume = {{12}}, year = {{2002}}, }