Disturbances in brain energy metabolism in insulin resistance and diabetes and Alzheimer's disease — Learnings from brain imaging biomarkers
(2020) In International Review of Neurobiology 154. p.111-130- Abstract
Medical imaging techniques, such as structural and functional magnetic resonance imaging and positron emission tomography, have been used to gain a better understanding of the alterations of the metabolic processes in the brain relating to type 2 diabetes melltius, insulin resistance and Alzheimer's disease. These studies have shown that there are several similarities in the effects that these seemingly disparate diseases have on the brain, and that some of the abnormalities are reversed by metabolic interventions. This review provides an overview of the overlap between these diseases using medical imaging, focusing on glucose metabolism, mitochondrial function and lipid metabolism.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/129e058b-2c74-47ec-a3d6-475a9bf02541
- author
- Heurling, Kerstin ; Johansson, Edvin LU and Leuzy, Antoine LU
- organization
- publishing date
- 2020-07-11
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Brain metabolites, Fatty acids, Hyperglycemia, Magnetic resonance imaging, Medical imaging, Metabolism, Neuroimaging, Positron emission tomography, Spectroscopy
- in
- International Review of Neurobiology
- volume
- 154
- pages
- 20 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85087791992
- pmid:32739001
- ISSN
- 0074-7742
- DOI
- 10.1016/bs.irn.2020.02.011
- language
- English
- LU publication?
- yes
- id
- 129e058b-2c74-47ec-a3d6-475a9bf02541
- date added to LUP
- 2020-07-22 13:14:38
- date last changed
- 2024-03-20 13:10:42
@article{129e058b-2c74-47ec-a3d6-475a9bf02541,
abstract = {{<p>Medical imaging techniques, such as structural and functional magnetic resonance imaging and positron emission tomography, have been used to gain a better understanding of the alterations of the metabolic processes in the brain relating to type 2 diabetes melltius, insulin resistance and Alzheimer's disease. These studies have shown that there are several similarities in the effects that these seemingly disparate diseases have on the brain, and that some of the abnormalities are reversed by metabolic interventions. This review provides an overview of the overlap between these diseases using medical imaging, focusing on glucose metabolism, mitochondrial function and lipid metabolism.</p>}},
author = {{Heurling, Kerstin and Johansson, Edvin and Leuzy, Antoine}},
issn = {{0074-7742}},
keywords = {{Brain metabolites; Fatty acids; Hyperglycemia; Magnetic resonance imaging; Medical imaging; Metabolism; Neuroimaging; Positron emission tomography; Spectroscopy}},
language = {{eng}},
month = {{07}},
pages = {{111--130}},
publisher = {{Elsevier}},
series = {{International Review of Neurobiology}},
title = {{Disturbances in brain energy metabolism in insulin resistance and diabetes and Alzheimer's disease — Learnings from brain imaging biomarkers}},
url = {{http://dx.doi.org/10.1016/bs.irn.2020.02.011}},
doi = {{10.1016/bs.irn.2020.02.011}},
volume = {{154}},
year = {{2020}},
}