Intrauterine infection may be a major cause of stillbirth in Sweden
(2001) In Acta Obstetricia et Gynecologica Scandinavica 80(6). p.511-518- Abstract
- Aim of the study. To investigate intrauterine infection as a cause for unexplained stillbirth.
Methods. Chorioamnionitis was studied in a material of stillbirths (117 subjects from the years 1985-1994) from a region in the south Sweden. Control material (126 alive and healthy newborns and with healthy mothers) was gathered from the same region.
Results. Chorioamnionitis was a common diagnosis both with stillbirths and 'healthy' deliveries (82 and 68%, respectively). Extension of the inflammation to decidua basalis was seven times more common among stillbirths than among controls (odds ratio 7.2, confidence interval 2.8-21.9). The most common bacteria found at cultures were Escherichia coli , Coagulase... (More) - Aim of the study. To investigate intrauterine infection as a cause for unexplained stillbirth.
Methods. Chorioamnionitis was studied in a material of stillbirths (117 subjects from the years 1985-1994) from a region in the south Sweden. Control material (126 alive and healthy newborns and with healthy mothers) was gathered from the same region.
Results. Chorioamnionitis was a common diagnosis both with stillbirths and 'healthy' deliveries (82 and 68%, respectively). Extension of the inflammation to decidua basalis was seven times more common among stillbirths than among controls (odds ratio 7.2, confidence interval 2.8-21.9). The most common bacteria found at cultures were Escherichia coli , Coagulase negative staphylococcus, Enterococcus faecalis and group B Streptococcus. The risk for stillbirth was doubled if both inflammation and bacteria were present (odds ratio 2.3, confidence interval 0.92-5.8). Meconium discharge was more common among stillbirths than controls (odds ratio=4.7, confidence interval 1.7-14). There were no differences in any respect regarding macerated and non-macerated stillbirths. Our findings are similar to the results from studies in developing countries except for the higher incidence of stillbirths in such countries.
Conclusions. Thus, a large part of otherwise unexplained stillbirths might be due to ascending infections. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/132609
- author
- Tolockiene, Egle ; Morsing, Eva LU ; Holst, Elisabeth ; Herbst, Andreas LU ; Ljungh, Åsa LU ; Svenningsen, Nils ; Hägerstrand, Inga and Nyström, Lennarth
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Obstetricia et Gynecologica Scandinavica
- volume
- 80
- issue
- 6
- pages
- 511 - 518
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000169176700005
- scopus:0035010158
- ISSN
- 1600-0412
- DOI
- 10.1034/j.1600-0412.2001.d01-151.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Paediatrics (Lund) (013002000), Division of Medical Microbiology (013250400), Department of Obstetrics and Gynaecology (Lund) (013018000)
- id
- 6947aa4f-ccca-41da-9f3f-810718b4d3a4 (old id 132609)
- date added to LUP
- 2016-04-01 16:50:26
- date last changed
- 2022-03-07 08:41:55
@article{6947aa4f-ccca-41da-9f3f-810718b4d3a4,
abstract = {{Aim of the study. To investigate intrauterine infection as a cause for unexplained stillbirth.<br/><br>
<br/><br>
Methods. Chorioamnionitis was studied in a material of stillbirths (117 subjects from the years 1985-1994) from a region in the south Sweden. Control material (126 alive and healthy newborns and with healthy mothers) was gathered from the same region.<br/><br>
<br/><br>
Results. Chorioamnionitis was a common diagnosis both with stillbirths and 'healthy' deliveries (82 and 68%, respectively). Extension of the inflammation to decidua basalis was seven times more common among stillbirths than among controls (odds ratio 7.2, confidence interval 2.8-21.9). The most common bacteria found at cultures were Escherichia coli , Coagulase negative staphylococcus, Enterococcus faecalis and group B Streptococcus. The risk for stillbirth was doubled if both inflammation and bacteria were present (odds ratio 2.3, confidence interval 0.92-5.8). Meconium discharge was more common among stillbirths than controls (odds ratio=4.7, confidence interval 1.7-14). There were no differences in any respect regarding macerated and non-macerated stillbirths. Our findings are similar to the results from studies in developing countries except for the higher incidence of stillbirths in such countries.<br/><br>
<br/><br>
Conclusions. Thus, a large part of otherwise unexplained stillbirths might be due to ascending infections.}},
author = {{Tolockiene, Egle and Morsing, Eva and Holst, Elisabeth and Herbst, Andreas and Ljungh, Åsa and Svenningsen, Nils and Hägerstrand, Inga and Nyström, Lennarth}},
issn = {{1600-0412}},
language = {{eng}},
number = {{6}},
pages = {{511--518}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Obstetricia et Gynecologica Scandinavica}},
title = {{Intrauterine infection may be a major cause of stillbirth in Sweden}},
url = {{https://lup.lub.lu.se/search/files/4795770/624324.pdf}},
doi = {{10.1034/j.1600-0412.2001.d01-151.x}},
volume = {{80}},
year = {{2001}},
}