Nuclear delivery of macromolecules: barriers and carriers.
(2005) In Advanced Drug Delivery Reviews 57(4). p.505-527- Abstract
- Recent evidence for efficient delivery of macromolecules, such as peptides and nucleic acids, from the cell exterior to the nucleus offers the interesting possibility of developing novel treatments directed at intranuclear targets. The findings should also stimulate the search for physiological ligands that utilize similar transport mechanisms to regulate pathobiological processes. Cytokines, growth factors and their receptors, as well as morphogens have all been shown to enter the nucleus to evoke biological responses in target cells. The rational design of intracellular drug delivery vehicles requires an increased understanding of the elaborate systems that mediate cellular communication and coordination with the extracellular... (More)
- Recent evidence for efficient delivery of macromolecules, such as peptides and nucleic acids, from the cell exterior to the nucleus offers the interesting possibility of developing novel treatments directed at intranuclear targets. The findings should also stimulate the search for physiological ligands that utilize similar transport mechanisms to regulate pathobiological processes. Cytokines, growth factors and their receptors, as well as morphogens have all been shown to enter the nucleus to evoke biological responses in target cells. The rational design of intracellular drug delivery vehicles requires an increased understanding of the elaborate systems that mediate cellular communication and coordination with the extracellular environment without inflicting on the integrity of the cell. This review discusses some aspects of the carriers and barriers in macromolecular transport. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/133644
- author
- Belting, Mattias LU ; Sandgren, Staffan LU and Wittrup, Anders LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Gene transfer, Endocytosis, Nucleic acid, Proteoglycan, Virus, Polybasic peptide, Drug delivery
- in
- Advanced Drug Delivery Reviews
- volume
- 57
- issue
- 4
- pages
- 505 - 527
- publisher
- Elsevier
- external identifiers
-
- pmid:15722161
- wos:000227570500004
- scopus:13844275977
- ISSN
- 0169-409X
- DOI
- 10.1016/j.addr.2004.10.004
- language
- English
- LU publication?
- yes
- id
- be1e7eee-82d5-497d-a54f-2ee9ab4ff00c (old id 133644)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15722161&dopt=Abstract
- date added to LUP
- 2016-04-01 11:55:59
- date last changed
- 2022-02-03 07:14:01
@article{be1e7eee-82d5-497d-a54f-2ee9ab4ff00c, abstract = {{Recent evidence for efficient delivery of macromolecules, such as peptides and nucleic acids, from the cell exterior to the nucleus offers the interesting possibility of developing novel treatments directed at intranuclear targets. The findings should also stimulate the search for physiological ligands that utilize similar transport mechanisms to regulate pathobiological processes. Cytokines, growth factors and their receptors, as well as morphogens have all been shown to enter the nucleus to evoke biological responses in target cells. The rational design of intracellular drug delivery vehicles requires an increased understanding of the elaborate systems that mediate cellular communication and coordination with the extracellular environment without inflicting on the integrity of the cell. This review discusses some aspects of the carriers and barriers in macromolecular transport.}}, author = {{Belting, Mattias and Sandgren, Staffan and Wittrup, Anders}}, issn = {{0169-409X}}, keywords = {{Gene transfer; Endocytosis; Nucleic acid; Proteoglycan; Virus; Polybasic peptide; Drug delivery}}, language = {{eng}}, number = {{4}}, pages = {{505--527}}, publisher = {{Elsevier}}, series = {{Advanced Drug Delivery Reviews}}, title = {{Nuclear delivery of macromolecules: barriers and carriers.}}, url = {{http://dx.doi.org/10.1016/j.addr.2004.10.004}}, doi = {{10.1016/j.addr.2004.10.004}}, volume = {{57}}, year = {{2005}}, }