Non-coding RNAs revealed during identification of genes involved in chicken immune responses
(2009) In Immunogenetics 61(1). p.55-70- Abstract
- Recent large-scale cDNA cloning studies have shown that a significant proportion of the transcripts expressed from vertebrate genomes do not appear to encode protein. Moreover, it was reported in mammals (human and mice) that these non-coding transcripts are expressed and regulated by mechanisms similar to those involved in the control of protein-coding genes. We have produced a collection of cDNA sequences from immunologically active tissues with the aim of discovering chicken genes involved in immune mechanisms, and we decided to explore the non-coding component of these immune-related libraries. After finding known non-coding RNAs (miRNA, snRNA, snoRNA), we identified new putative mRNA-like non-coding RNAs. We characterised their... (More)
- Recent large-scale cDNA cloning studies have shown that a significant proportion of the transcripts expressed from vertebrate genomes do not appear to encode protein. Moreover, it was reported in mammals (human and mice) that these non-coding transcripts are expressed and regulated by mechanisms similar to those involved in the control of protein-coding genes. We have produced a collection of cDNA sequences from immunologically active tissues with the aim of discovering chicken genes involved in immune mechanisms, and we decided to explore the non-coding component of these immune-related libraries. After finding known non-coding RNAs (miRNA, snRNA, snoRNA), we identified new putative mRNA-like non-coding RNAs. We characterised their expression profiles in immune-related samples. Some of them showed changes in expression following viral infections. As they exhibit patterns of expression that parallel the behaviour of protein-coding RNAs in immune tissues, our study suggests that they could play an active role in the immune response. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1374985
- author
- Ahanda, Marie-Laure Endale ; Ruby, Thomas ; Wittzell, Hayenkan LU ; Bed'Hom, Bertrand ; Chausse, Anne-Marie ; Morin, Veronique ; Oudin, Anne ; Chevalier, Catherine ; Young, John R. and Zoorob, Rima
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Non-coding RNAs, Microarray, Immune response, Chicken
- in
- Immunogenetics
- volume
- 61
- issue
- 1
- pages
- 55 - 70
- publisher
- Springer
- external identifiers
-
- wos:000263060800005
- scopus:59449084786
- ISSN
- 1432-1211
- DOI
- 10.1007/s00251-008-0337-8
- language
- English
- LU publication?
- yes
- id
- cbbba9ba-06a0-4d45-b59e-cd2982decc9a (old id 1374985)
- date added to LUP
- 2016-04-01 13:16:37
- date last changed
- 2024-01-09 11:15:07
@article{cbbba9ba-06a0-4d45-b59e-cd2982decc9a, abstract = {{Recent large-scale cDNA cloning studies have shown that a significant proportion of the transcripts expressed from vertebrate genomes do not appear to encode protein. Moreover, it was reported in mammals (human and mice) that these non-coding transcripts are expressed and regulated by mechanisms similar to those involved in the control of protein-coding genes. We have produced a collection of cDNA sequences from immunologically active tissues with the aim of discovering chicken genes involved in immune mechanisms, and we decided to explore the non-coding component of these immune-related libraries. After finding known non-coding RNAs (miRNA, snRNA, snoRNA), we identified new putative mRNA-like non-coding RNAs. We characterised their expression profiles in immune-related samples. Some of them showed changes in expression following viral infections. As they exhibit patterns of expression that parallel the behaviour of protein-coding RNAs in immune tissues, our study suggests that they could play an active role in the immune response.}}, author = {{Ahanda, Marie-Laure Endale and Ruby, Thomas and Wittzell, Hayenkan and Bed'Hom, Bertrand and Chausse, Anne-Marie and Morin, Veronique and Oudin, Anne and Chevalier, Catherine and Young, John R. and Zoorob, Rima}}, issn = {{1432-1211}}, keywords = {{Non-coding RNAs; Microarray; Immune response; Chicken}}, language = {{eng}}, number = {{1}}, pages = {{55--70}}, publisher = {{Springer}}, series = {{Immunogenetics}}, title = {{Non-coding RNAs revealed during identification of genes involved in chicken immune responses}}, url = {{http://dx.doi.org/10.1007/s00251-008-0337-8}}, doi = {{10.1007/s00251-008-0337-8}}, volume = {{61}}, year = {{2009}}, }